Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Daniel V Santi"'
Autor:
Wei Chen, Thomas A Waldmann, Anusara Daenthanasanmak, Sigrid P Dubois, Jürgen R Müller, John A Hangasky, Ralph Reid, Daniel V Santi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/ed308cd4754b429b9c2a44c2b53607f8
Autor:
Jeff Henise, John A. Hangasky, Deborah Charych, Christopher W. Carreras, Gary W. Ashley, Daniel V. Santi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Intratumoral (IT) therapy is a powerful method of controlling tumor growth, but a major unsolved problem is the rapidity that injected drugs exit tumors, limiting on-target exposure and efficacy. We have developed a generic long acting IT de
Externí odkaz:
https://doaj.org/article/3a77d0a089da45609de06d882f50e4b6
Autor:
Jinkyu Jung, Eric L. Schneider, Wei Zhang, Hua Song, Meili Zhang, William Chou, Niranjan Meher, Henry F. VanBrocklin, Mary Helen Barcellos-Hoff, Tomoko Ozawa, Mark R. Gilbert, Daniel V. Santi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Central nervous system tumors have resisted effective chemotherapy because most therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between ~ 10 and 100 nm accumulate in many solid tumors by the enhanced permeability a
Externí odkaz:
https://doaj.org/article/3d5e6d583d9c4105b0310e06048dd4f3
Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity
Autor:
John A. Hangasky, Rocío del Valle Fernández, Dimitris Stellas, Guillermo Hails, Sevasti Karaliota, Gary W. Ashley, Barbara K. Felber, George N. Pavlakis, Daniel V. Santi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionIL-15 agonists hold promise as immunotherapeutics due to their ability to induce the proliferation and expansion of cytotoxic immune cells including natural killer (NK) and CD8+ T cells. However, they generally have short half-lives that
Externí odkaz:
https://doaj.org/article/e43365ab5c1643469ee96abce7c5c45e
Publikováno v:
Cancer Research Communications. 3:908-916
Exatecan (Exa) is a very potent inhibitor of topoisomerase I and anticancer agent. It has been intensively studied as a single agent, a large macromolecular conjugate and as the payload component of antigen-dependent antibody–drug conjugates. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62df7ec74d7564d3b27b090471538915
https://doi.org/10.1158/2767-9764.crc-22-0517
https://doi.org/10.1158/2767-9764.crc-22-0517
Publikováno v:
Engineering Reports, Vol 2, Iss 8, Pp n/a-n/a (2020)
Abstract The purpose of this work was to develop equipment and procedures for large‐scale aseptic production of injectable microsphere (MS) drug conjugates. The two major challenges were (a) to prepare sufficient amounts of MSs for clinical trials,
Externí odkaz:
https://doaj.org/article/3abdd76729364ad3bc0723af8bddf640
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Interleukin-15 (IL-15) is crucial for the proliferation and survival of NK and CD8+ T memory cells, and of significant interest in immuno-oncology. Immune cell expansion requires continuous IL-15 exposure above a threshold concentration for an extend
Externí odkaz:
https://doaj.org/article/7826ac9ece4b4dd48574fb5a2e9fa746
Publikováno v:
Engineering Reports, Vol 2, Iss 1, Pp n/a-n/a (2020)
Sterilization of degradable polymeric biomaterials intended for injection presents a formidable challenge. Often, either the polymer backbone or labile crosslinks controlling degradation are adversely affected by commonly used sterilization methods.
Externí odkaz:
https://doaj.org/article/da309732a0e7424682c6dea3dcbe51fc
Autor:
Niranjan Meher, Gary W. Ashley, Anil P. Bidkar, Suchi Dhrona, Cyril Fong, Shaun D. Fontaine, Denis R. Beckford Vera, David M. Wilson, Youngho Seo, Daniel V. Santi, Henry F. VanBrocklin, Robert R. Flavell
Publikováno v:
ACS applied materials & interfaces, vol 14, iss 45
Tumoral uptake of large-size nanoparticles is mediated by the enhanced permeability and retention (EPR) effect, with variable accumulation and heterogenous tumor tissue penetration depending on the tumor phenotype. The performance of nanocarriers via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbddcc2aae9f973792d37de877848af5
https://doi.org/10.1021/acsami.2c15095
https://doi.org/10.1021/acsami.2c15095
Autor:
Jeff Henise, Shaun D. Fontaine, Brian R. Hearn, Samuel J. Pfaff, Eric L. Schneider, Julia Malato, Donghui Wang, Byron Hann, Gary W. Ashley, Daniel V. Santi
Publikováno v:
International Journal of Polymer Science, Vol 2019 (2019)
The degradation of Tetra-PEG hydrogels containing β-eliminative crosslinks has been studied in order to provide an in vitro-in vivo correlation for the use of these hydrogels in our chemically controlled drug delivery system. We measured time-depend
Externí odkaz:
https://doaj.org/article/4d40cbe04a32493b86028345287c8f5e