Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Daniel Trcka"'
Autor:
Layla Pires, Brian C. Wilson, Rod Bremner, Amanda Lang, Jeremie Larouche, Ryan McDonald, Joel D. Pearson, Daniel Trcka, Jeff Wrana, James Wu, Cari M. Whyne
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The lack of therapeutic options to fight Covid-19 has contributed to the current global pandemic. Despite the emergence of effective vaccines, development of broad-spectrum antiviral treatment remains a significant challenge, in which antimi
Externí odkaz:
https://doaj.org/article/7e404c800941409a9e0dacbf3796c276
Autor:
Derek K.L. Tsang, Ryan J. Wang, Oliver De Sa, Arshad Ayyaz, Elisabeth G. Foerster, Giuliano Bayer, Shawn Goyal, Daniel Trcka, Bibaswan Ghoshal, Jeffrey L. Wrana, Stephen E. Girardin, Dana J. Philpott
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote homeostasis. Understanding the dynamic relationship between microbes and intestinal epithelial
Externí odkaz:
https://doaj.org/article/0018c12ca633427895fd121a96234369
Autor:
Joel D. Pearson, Daniel Trcka, Suying Lu, Sharon J. Hyduk, Mark Jen, Marie-Ming Aynaud, J. Javier Hernández, Philippos Peidis, Miriam Barrios-Rodiles, Kin Chan, Jim Woodgett, Tony Mazzulli, Liliana Attisano, Laurence Pelletier, Myron I. Cybulsky, Jeffrey L. Wrana, Rod Bremner
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background Sensitive, rapid, and accessible diagnostics continue to be critical to track the COVID-19 pandemic caused by the SARS-CoV-2 virus. RT-qPCR is the gold standard test, and comparison of methodologies and reagents, utilizing patient
Externí odkaz:
https://doaj.org/article/550187229e544508bd7d16774946297a
Autor:
Marie-Ming Aynaud, J. Javier Hernandez, Seda Barutcu, Ulrich Braunschweig, Kin Chan, Joel D. Pearson, Daniel Trcka, Suzanna L. Prosser, Jaeyoun Kim, Miriam Barrios-Rodiles, Mark Jen, Siyuan Song, Jess Shen, Christine Bruce, Bryn Hazlett, Susan Poutanen, Liliana Attisano, Rod Bremner, Benjamin J. Blencowe, Tony Mazzulli, Hong Han, Laurence Pelletier, Jeffrey L. Wrana
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Wide-spread outbreaks of pathogens require high intensity testing to manage. Here, the authors present C19-SPAR-Seq, a scalable and automated platform to analyse tens of thousands of SARS-CoV-2 patient samples in a single run.
Externí odkaz:
https://doaj.org/article/ac044901fa7a4d629bfedd519a0399c2
Autor:
Evan Amalfitano, Margot Karlikow, Masoud Norouzi, Katariina Jaenes, Seray Cicek, Fahim Masum, Peivand Sadat Mousavi, Yuxiu Guo, Laura Tang, Andrew Sydor, Duo Ma, Joel D. Pearson, Daniel Trcka, Mathieu Pinette, Aruna Ambagala, Shawn Babiuk, Bradley Pickering, Jeff Wrana, Rod Bremner, Tony Mazzulli, David Sinton, John H. Brumell, Alexander A. Green, Keith Pardee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Getting synthetic biology circuit-based sensors into field applications is still a challenge. Here the authors combine a circuit sensor with a glucose meter for small analyte and nucleic acid detection.
Externí odkaz:
https://doaj.org/article/3cb9f77bab4e4f33b765a22e58579292
Autor:
Connor Yanchus, Kristen L. Drucker, Thomas M. Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B. De Lorenzo, Asma Ali, Paul A. Decker, Matt L. Kosel, Arijit Panda, Khalid N. Al-Zahrani, Lingyan Jiang, Jared W. L. Browning, Chris Lowden, Michael Geuenich, J. Javier Hernandez, Jessica T. Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W. Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Daniel J. Murphy, Liguo Wang, Alexej Abyzov, James W. Dennis, Philipp G. Maass, Kieran Campbell, Michael D. Wilson, Daniel H. Lachance, Margaret Wrensch, John Wiencke, Tak Mak, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Jeffrey Wrana, Michael D. Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E. Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M. Ida, Evgeny Z. Kvon, Robert B. Jenkins, Daniel Schramek
Publikováno v:
Science
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-grade gli
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Liliana Attisano, Laurence Pelletier, Philippos Peidis, Tony Mazzulli, Miriam Barrios-Rodiles, Marie-Ming Aynaud, Sharon J. Hyduk, Joel Pearson, James R. Woodgett, Kin Chan, Jeffrey L. Wrana, Daniel Trcka, Myron I. Cybulsky, Mark Jen, Suying Lu, Rod Bremner, J. Javier Hernandez
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-12 (2021)
Virology Journal
Virology Journal
BackgroundSensitive, rapid, and accessible diagnostics continue to be critical to track the COVID-19 pandemic caused by the SARS-CoV-2 virus. RT-qPCR is the gold standard test, and comparison of methodologies and reagents, utilizing patient samples,
Autor:
Jess Shen, Ulrich Braunschweig, Joel Pearson, Jeffrey L. Wrana, Laurence Pelletier, Benjamin J. Blencowe, Jaeyoun Kim, Siyuan Song, Suzanna L. Prosser, Tony Mazzulli, Seda Barutcu, Bryn Hazlett, Miriam Barrios-Rodiles, Daniel Trcka, Mark Jen, Liliana Attisano, Rod Bremner, Marie-Ming Aynaud, J. Javier Hernandez, Christine Bruce, Susan M. Poutanen, Kin Chan, Hong Han
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. Here, we describe “Systematic Parallel Analysis of RNA coupled to Sequencing for Covid-19 screening” (C19-SPAR-Seq), a multip