Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Daniel T.S. Pak"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 3-4 (2021)
ABSTRACT IMPACT: Optimization of primary septal-hippocampal co-cultures facilitates studying central cholinergic synapse formation and dysfunction OBJECTIVES/GOALS: Septal cholinergic innervation to the hippocampus is critical for normal learning and
Externí odkaz:
https://doaj.org/article/c83aefc03140492f8b5238cc3ee77ace
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 14-14 (2020)
OBJECTIVES/GOALS: Septal cholinergic innervation to the hippocampus is critical for normal learning and memory and is severely degenerated in Alzheimer’s disease. To understand the molecular events underlying this loss, we optimized a primary septa
Externí odkaz:
https://doaj.org/article/c87f29b2fda74cb9ac4dd6b4c11d8833
Publikováno v:
Cellular and molecular neurobiology. 41(8)
Septal innervation of basal forebrain cholinergic neurons to the hippocampus is critical for normal learning and memory and is severely degenerated in Alzheimer's disease. To understand the molecular events underlying physiological cholinergic synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a984e0513c148dbfc8f649e8983062
https://pubmed.ncbi.nlm.nih.gov/32860154
https://pubmed.ncbi.nlm.nih.gov/32860154
Autor:
Patrick A. Forcelli, Jian-Young Wu, Adam Caccavano, Daniel T.S. Pak, P. Lorenzo Bozzelli, Stefano Vicini, Katherine Conant
Publikováno v:
J Neurosci
Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ripples (SWRs), hippocampal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8e1dd991bd2a810317447b0f3b6a3f
https://doi.org/10.1101/2020.02.21.959676
https://doi.org/10.1101/2020.02.21.959676
Publikováno v:
Journal of Clinical and Translational Science. 5:3-4
IMPACT: Optimization of primary septal-hippocampal co-cultures facilitates studying central cholinergic synapse formation and dysfunction OBJECTIVES/GOALS: Septal cholinergic innervation to the hippocampus is critical for normal learning and memory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fbf7166c816507250660d636d36849b
https://doi.org/10.1017/cts.2021.411
https://doi.org/10.1017/cts.2021.411
Publikováno v:
Neuropharmacology. 117:387-400
Alzheimer’s disease (AD) is a neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces amyloid β (Aβ), the major component of hallmark AD plaques. Synaptic activity stimulates APP cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3675bb5775ee4184f8b5a0b19290b3e6
https://doi.org/10.1016/j.neuropharm.2017.02.027
https://doi.org/10.1016/j.neuropharm.2017.02.027
Autor:
Ziyue Zhang, Mikael Rauf, Daniel T.S. Pak, Sarra Djemil, Rhonda Dzakpasu, Xin Chen, Jisoo Lee
Publikováno v:
J Neurochem
Nicotinic acetylcholine receptors (nAChRs) are known to play a role in cognitive functions of the hippocampus, such as memory consolidation. Given that they conduct Ca2+ and are capable of regulating the release of glutamate and γ-aminobutyric acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3663edcf45802f96acf63df09f763159
https://pubmed.ncbi.nlm.nih.gov/31821553
https://pubmed.ncbi.nlm.nih.gov/31821553
Microtubule-associated protein 2 mediates induction of long-term potentiation in hippocampal neurons
Autor:
Seulgi Noh, Ryan Bellmore, You-Na Jang, Ji Young Mun, Bridget N. Queenan, Kea Joo Lee, Hyungju Park, Nari Kim, Yoonju Kim, Hye-Yeon Kim, Ji-Young Kim, Jong-Cheol Rah, Daniel T.S. Pak
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(5)
Microtubule-associated protein (MAP) 2 has been perceived as a static cytoskeletal protein enriched in neuronal dendritic shafts. Emerging evidence indicates dynamic functions for various MAPs in activity-dependent synaptic plasticity. However, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac8a00e4d973c2159ed962ea54c8dce
https://pubmed.ncbi.nlm.nih.gov/32237183
https://pubmed.ncbi.nlm.nih.gov/32237183
Autor:
Jung Min Song, Emily Isabella Moffat, You Me Sung, Daniel T.S. Pak, Andrew Chung, Hyang Sook Hoe, Hyejin Yoon, Jin Han Nam, Jungsu Kim, Mira Jung
Publikováno v:
Journal of Alzheimer's Disease. 51:591-604
Background: The accumulation of amyloid- (A) leads to the loss of dendritic spines and synapses, which is hypothesized to cause cognitive impairments in Alzheimer’s disease (AD) patients. In our previous study, we demonstrated that a novel mercapto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef4928ff9b6597b5b4c2206dd88e4ca
https://doi.org/10.3233/jad-150717
https://doi.org/10.3233/jad-150717
Autor:
Daniel T.S. Pak, Zikai Zhou, Yuehua Zhu, Guiqin He, Wei Xie, Zhengping Jia, Rui Dang, Celeste Leung, Junxia Qi, An Liu
Publikováno v:
The Journal of Cell Biology
The C-terminal domain of NLG1 is sufficient to enhance spine and synapse number and to modulate synaptic plasticity, and it exerts these effects via its interaction with SPAR and the subsequent activation of LIMK1/cofilin-mediated actin reorganizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c94bcb8f4535f95c7ccd3944511302
https://doi.org/10.1083/jcb.201509023
https://doi.org/10.1083/jcb.201509023