Výsledky vyhledávání - "Daniel T.L. Chow"

Supplementary Methods from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

Autor: Yun-chung Leung, Sui-Yi Kwok, Steven H.K. Chung, Daniel T.L. Chow, Justin Y.T. Lam, Raymond M.H. Wong, Liz L. Yang, Ka-Chun Chau, Wing Lun Lee, Chak-Ho Yuen, Xiaoxu Lu, Yu-On Leung, Jeremy P.H. Chow, Yijun Cai

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d784a779c75605545759ca38cec95e1
https://doi.org/10.1158/1535-7163.22520617

Zobrazit plný text záznamu

Supplementary Fig. S5 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

Treatment with NEI-01 observably decreased the leukemia cells as well as recovered the normal structure in bone marrow, spleen and liver from mice bearing AM5512 PDX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0645dfa0f0d466a3f0ba19743fad0472
https://doi.org/10.1158/1535-7163.22520620

Zobrazit plný text záznamu

Supplementary Fig. S1 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

ASS1 expression in pan-cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8ff48c28344923cfb2901d142bb1f4
https://doi.org/10.1158/1535-7163.22520632

Zobrazit plný text záznamu

Supplementary Fig. S2 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

ASS1 expression in AML patients and its effect on survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a30fe232fa4e9f9530650719dee5786
https://doi.org/10.1158/1535-7163.22520629

Zobrazit plný text záznamu

Supplementary Fig. S4 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

Treatment with NEI-01 significantly inhibited cell proliferation by induction of cell cycle arrest and apoptosis in mouse ASS1-deficient C1498 cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb3f67eed8af958ff6bd3fe2b280db3
https://doi.org/10.1158/1535-7163.22520623.v1

Zobrazit plný text záznamu

Supplementary Fig. S3 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

ASS1 expression in AML cell lines and normal fibroblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f18392c80a10b32ba974fbc35366d8
https://doi.org/10.1158/1535-7163.22520626

Zobrazit plný text záznamu

Data from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

Recent studies have revealed that targeting amino acid metabolic enzymes is a promising strategy in cancer therapy. Acute myeloid leukemia (AML) downregulates the expression of argininosuccinate synthase (ASS1), a recognized rate-limiting enzyme for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c039dc7fcbe0db07570ff3cc846a864
https://doi.org/10.1158/1535-7163.c.6542704

Zobrazit plný text záznamu

NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both In Vitro and In Vivo

Autor: Steven H.K. Chung, Raymond M.H. Wong, Justin Y.T. Lam, Yu-On Leung, Xiaoxu Lu, Yun Chung Leung, Ka-Chun Chau, Sui-Yi Kwok, Liz L. Yang, Yijun Cai, Wing Lun Lee, Chak-Ho Yuen, Jeremy Pak Hong Chow, Daniel T.L. Chow

Publikováno v: Molecular Cancer Therapeutics. 20:2218-2227

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e33ca4f40abc1a3673c57247a5a266b6
https://doi.org/10.1158/1535-7163.mct-21-0120

Zobrazit plný text záznamu

A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells

Autor: Steven H.K. Chung, Raymond M.H. Wong, Yu On Leung, Yijun Cai, Oscar M. Leung, Alan W.L. Law, Sui Yi Kwok, Ka Chun Chau, Yun Chung Leung, Jeremy P.H. Chow, Daniel T.L. Chow, Ka Ying Ng

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231633 (2020)

Arginine deprivation cancer therapy targets certain types of malignancies with positive result in many studies and clinical trials. NEI-01 was designed as a novel arginine-depleting enzyme comprising an albumin binding domain capable of binding to hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b8e2e4e9eccf93d34efd8f26ad03f0
https://doi.org/10.1371/journal.pone.0231633

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání