Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Daniel T. Tresnak"'
Autor:
Daniel T. Tresnak, Benjamin J. Hackel
Publikováno v:
ACS Synthetic Biology. 12:249-264
Antibiotic-resistant infectious disease is a critical challenge to human health. Antimicrobial proteins offer a compelling solution if engineered for potency, selectivity, and physiological stability. Lysins, which lyse cells via degradation of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d392ef97cec1912809b9ab4ab3ecc9
https://doi.org/10.1021/acssynbio.2c00509
https://doi.org/10.1021/acssynbio.2c00509
Autor:
Alexander W. Golinski, Daniel T. Tresnak, Katharina A. Fransen, Seth C. Ritter, Benjamin J. Hackel, Matthew P. Dejong
Publikováno v:
ACS Synth Biol
Developing potent antimicrobials, and platforms for their study and engineering, is critical as antibiotic resistance grows. A high-throughput method to quantify antimicrobial peptide and protein (AMP) activity across a broad continuum would be power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831e5eed4f1f74ea9a2ed3070c45020
https://doi.org/10.1101/2021.05.13.444096
https://doi.org/10.1101/2021.05.13.444096
Autor:
Daniel T. Tresnak, Benjamin J. Hackel
Publikováno v:
Appl Environ Microbiol
Class IIa bacteriocin antimicrobial peptides (AMPs) are a compelling alternative to current antimicrobials because of potential specific activity toward antibiotic-resistant bacteria, including vancomycin-resistant enterococci. Engineering of these m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a913f9e31a7075a840581dcc72c4ba
https://doi.org/10.1128/aem.01646-20
https://doi.org/10.1128/aem.01646-20
Publikováno v:
Appl Environ Microbiol
Bacteriophage-derived lysin proteins are potentially effective antimicrobials that would benefit from engineered improvements to their bioavailability and specific activity. Here, the catalytic domain of LysEFm5, a lysin with activity against vancomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2641ccf55d22489a04d53efdcbee46
https://doi.org/10.1128/aem.02051-19
https://doi.org/10.1128/aem.02051-19
Publikováno v:
Biotechnol Bioeng
Proline-rich antimicrobial peptides (PrAMPs) kill bacteria via a nonlytic mechanism in which they permeate through the outer membrane, utilize protein-mediated transport across the inner membrane, and target the ribosome to inhibit protein synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2a41c33c3fc3f812f276b1bd08d42
https://europepmc.org/articles/PMC6726534/
https://europepmc.org/articles/PMC6726534/