Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Daniel T. Starczynowski"'
Autor:
Laura Barreyro, Avery M. Sampson, Kathleen Hueneman, Kwangmin Choi, Susanne Christie, Vighnesh Ramesh, Michael Wyder, Dehua Wang, Mario Pujato, Kenneth D. Greis, Gang Huang, Daniel T. Starczynowski
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109809- (2024)
Summary: Dysregulated innate immune signaling is linked to preleukemic conditions and myeloid malignancies. However, it is unknown whether sustained innate immune signaling contributes to malignant transformation. Here we show that cell-intrinsic inn
Externí odkaz:
https://doaj.org/article/27e314a429b04c5388a0550ebdd9ec6f
Autor:
Guillermo Garcia-Manero, Uwe Platzbecker, Kian-Huat Lim, Grzegorz Nowakowski, Omar Abdel-Wahab, Hagop Kantarjian, Amit Verma, Daniel T. Starczynowski
Publikováno v:
Frontiers in Hematology, Vol 3 (2024)
The intracellular serine/threonine interleukin 1 receptor-associated kinase 4 (IRAK4) is necessary for most signaling by activated Toll-like receptors (TLRs). Activation of IRAK4 drives activation of nuclear factor kappa B (NF-κB) and so promotes ce
Externí odkaz:
https://doaj.org/article/636932ab680b4146a8c5950be2b3129a
Autor:
Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Guo Ge, Lyndsey Bolanos, Mark Wunderlich, Johann-Christoph Jann, Alina Wein, Eva Altrock, Marie Demmerle, Sanjay Mukherjee, Abdullah Mahmood Ali, Felicitas Rapp, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Melda Göl, Ahmed Jawhar, Ali Darwich, Patrick Wuchter, Christel Weiss, Azra Raza, Jason M. Foulks, Daniel T. Starczynowski, Feng-Chun Yang, Georgia Metzgeroth, Laurenz Steiner, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
Inhibitors of anti-apoptotic BCL-2 family proteins in combination with chemotherapy and hypomethylating agents (HMA) are promising therapeutic approaches in acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). Alvocidib, a cycl
Externí odkaz:
https://doaj.org/article/587fe7bf73e84c44b2b804ab4433a656
Autor:
Zhuoer Xie, Daniel T. Starczynowski
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/8b97d6e3d172439c8d7fe84a4425b547
Autor:
Tomoya Muto, Callum S. Walker, Puneet Agarwal, Eric Vick, Avery Sampson, Kwangmin Choi, Madeline Niederkorn, Chiharu Ishikawa, Kathleen Hueneman, Melinda Varney, Daniel T. Starczynowski
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and emerging evidence suggests that MDS hematopoietic stem and progenitor cells (HSPC) exhibit an altered response to inflammation. Deletion of chromosome 5 (del(5q))
Externí odkaz:
https://doaj.org/article/38750250ce874c0bb56f9b40f35e488d
Autor:
Puneet Agarwal, Hui Li, Kwangmin Choi, Kathleen Hueneman, Jianbo He, Robert S. Welner, Daniel T. Starczynowski, Ravi Bhatia
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109386- (2021)
Summary: Chronic myeloid leukemia (CML) is propagated by leukemia stem cells (LSCs) that are not eradicated by tyrosine kinase inhibitor (TKI) treatment and persist as a source of disease recurrence. Bone marrow (BM) mesenchymal niches play an essent
Externí odkaz:
https://doaj.org/article/0559a6200b904336acf190e8f10c7f7b
Autor:
Molly A. Smith, Ashley E. Culver-Cochran, Emmalee R. Adelman, Garrett W. Rhyasen, Averil Ma, Maria E. Figueroa, Daniel T. Starczynowski
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Hematopoietic stem and progenitor cells (HSPC) experience a functional decline in response to chronic inflammation or aging. Haploinsufficiency of A20, or TNFAIP3, an innate immune regulator, is associated with a variety of autoimmune, inflammatory,
Externí odkaz:
https://doaj.org/article/36c2b55c0df447f497aa91330ee398fb
Autor:
Madeline Niederkorn, Kathleen Hueneman, Kwangmin Choi, Melinda E. Varney, Laurel Romano, Mario A. Pujato, Kenneth D. Greis, Jun-ichiro Inoue, Ruhikanta Meetei, Daniel T. Starczynowski
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2776-2790.e6 (2020)
Summary: TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in myeloid malignancies with deletion of chromosome 5q. Employing a combination of proteomic and genetic approaches, we find that TIFAB regulates ubiquitin-sp
Externí odkaz:
https://doaj.org/article/5461a6c7392c4dcfb7f7ff2b3992f655
Autor:
Jing Fang, Tomoya Muto, Maria Kleppe, Lyndsey C. Bolanos, Kathleen M. Hueneman, Callum S. Walker, Leesa Sampson, Ashley M. Wellendorf, Kashish Chetal, Kwangmin Choi, Nathan Salomonis, Yongwon Choi, Yi Zheng, Jose A. Cancelas, Ross L. Levine, Daniel T. Starczynowski
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1250-1262 (2018)
Summary: Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe TRAF
Externí odkaz:
https://doaj.org/article/4daedec41a394d7e95b5498a1278e32b
Autor:
Kyung Hee Chang, Amitava Sengupta, Ramesh C. Nayak, Angeles Duran, Sang Jun Lee, Ronald G. Pratt, Ashley M. Wellendorf, Sarah E. Hill, Marcus Watkins, Daniel Gonzalez-Nieto, Bruce J. Aronow, Daniel T. Starczynowski, Roberto Civitelli, Maria T. Diaz-Meco, Jorge Moscat, Jose A. Cancelas
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2084-2097 (2014)
In the bone marrow (BM), hematopoietic progenitors (HPs) reside in specific anatomical niches near osteoblasts (Obs), macrophages (MΦs), and other cells forming the BM microenvironment. A connection between immunosurveillance and traffic of HP has b
Externí odkaz:
https://doaj.org/article/61c03b893acd42ada2b3efb6cecf74d3