Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Daniel T. Monaghan"'
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Autor:
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold s
Externí odkaz:
https://doaj.org/article/9cf4ff26eb1b4740b5b19c5f54918691
Autor:
Divyan A. Chopra, Kiran Sapkota, Mark W. Irvine, Guangyu Fang, David E. Jane, Daniel T. Monaghan, Shashank M. Dravid
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested t
Externí odkaz:
https://doaj.org/article/9f33dc1aa5444fdbaec987412ab161fc
Publikováno v:
Neuropharmacology. 210
40 years ago, Jeff Watkins and Richard (Dick) Evans (Watkins and Evans, 1981) published their review on excitatory amino acids. The review, combined with the tools that they and their colleagues developed, significantly changed the field of neurobiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fa6cebfa6e368046474e212252ec4e
https://pubmed.ncbi.nlm.nih.gov/35307365
https://pubmed.ncbi.nlm.nih.gov/35307365
Autor:
Neil Bannister, R. Rothärmel, Zuner A. Bortolotto, Shashank M. Dravid, Rachael Ingram, Guangyu Fang, Graham L. Collingridge, Kiran Sapkota, A. Volianskis, John Georgiou, Divyan Chopra, Blaise M. Costa, Erica S. Burnell, Mark W. Irvine, David E. Jane, Daniel T. Monaghan, Adina T. Michael-Titus, R. Volianskis
Publikováno v:
Neuropharmacology
Different types of memory are thought to rely on different types of synaptic plasticity, many of which depend on the activation of the N-Methyl-D Aspartate (NMDA) subtype of glutamate receptors. Accordingly, there is considerable interest in the poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9d736cdd516f56b3b2f54ce83ee476
https://hdl.handle.net/10919/111856
https://hdl.handle.net/10919/111856
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Autor:
Minjun Li, David E. Jane, Graham L. Collingridge, Erica S. Burnell, Robert J. Thatcher, Kiran Sapkota, Arturas Volianskis, Daniel T. Monaghan, Noriko Simorowski, Hiro Furukawa, Mark W. Irvine, Jue Xiang Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications
N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f84ba3487ef9967bcf8d4394ee1ae
Autor:
Shashank M. Dravid, Kiran Sapkota, Daniel T. Monaghan, Erica S. Burnell, David E. Jane, Mark W. Irvine, Guangyu Fang, Dinesh Y. Gawande
Publikováno v:
Neuropharmacology. 201:108818
N-methyl- d -aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR activity can lead to neuronal cell death and epilepsy, there is interest in developing NMDAR n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6206924b5904f9414ae8507790ab847
https://doi.org/10.1016/j.neuropharm.2021.108818
https://doi.org/10.1016/j.neuropharm.2021.108818
Autor:
Paul Synowicki, Daniel T. Monaghan, Lucy Chung, Shengxi He, Zhihao Mao, Yuning Zhang, Alex I. Wiesman, Tony W. Wilson, Christopher Mesnard
Publikováno v:
Brain Res
NMDA receptor (NMDAR) antagonists such as ketamine, can reproduce many of the symptoms of schizophrenia. A reliable indicator of NMDAR channel blocker action in vivo is the augmentation of neuronal oscillation power. Since the coordinated and rhythmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314cc6b4a10e8749e6104afe44387b73
https://pubmed.ncbi.nlm.nih.gov/31786200
https://pubmed.ncbi.nlm.nih.gov/31786200
Autor:
David E. Jane, Daniel T. Monaghan, Erica S. Burnell, Kiran Sapkota, Guangyu Fang, Mark W. Irvine
Publikováno v:
Burnell, E S, Irvine, M, Fang, G, Sapkota, K, Jane, D E & Monaghan, D T 2019, ' Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors : Structure-Activity Relationships and Mechanisms of Action ', Journal of Medicinal Chemistry, vol. 62, no. 1, pp. 3-23 . https://doi.org/10.1021/acs.jmedchem.7b01640
Excitatory activity in the CNS is predominately mediated by l-glutamate through several families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate receptor (NMDAR) family has many critical roles in CNS function and in vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e64a9a4b36cd6a367632d71ee3ffab1
http://www.scopus.com/inward/record.url?scp=85059506923&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85059506923&partnerID=8YFLogxK
Autor:
Kiran Sapkota, David E. Jane, Erica S. Burnell, Kim Dore, Guangyu Fang, Mark W. Irvine, Kang Tang, Daniel T. Monaghan, Roberto Malinow
Publikováno v:
Sapkota, K, Dore, K, Tang, K, Irvine, M, Fang, G, Burnell, E S, Malinow, R, Jane, D E & Monaghan, D T 2019, ' The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators ', Biochemical Pharmacology, vol. 159, pp. 140-153 . https://doi.org/10.1016/j.bcp.2018.11.018
N-methyl-D-aspartate receptors (NMDARs) have multiple prominent roles in CNS function but their excessive or insufficient activity contributes to neuropathological/psychiatric disorders. Consequently, a variety of positive and negative allosteric mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedbdbc500f79f83e32b24bc6b51ca14
http://www.scopus.com/inward/record.url?scp=85058054700&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85058054700&partnerID=8YFLogxK
Autor:
Zhihao Mao, Paul Synowicki, Dillon Lieber, Vivek Gautam, Meng Liu, Daniel T. Monaghan, Kiran Sapkota, Tsuneya Ikezu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:702-711
The dissociative anesthetic ketamine elicits symptoms of schizophrenia at subanesthetic doses by blocking N-methyl-d-aspartate receptors (NMDARs). This property led to a variety of studies resulting in the now well-supported theory that hypofunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbfb217737d2485d76c62e9a0656030
https://doi.org/10.1124/jpet.115.230391
https://doi.org/10.1124/jpet.115.230391