Výsledky vyhledávání - "Daniel T. Klink"

Development of Hip Bone Geometry During Gender‐Affirming Hormone Therapy in Transgender Adolescents Resembles That of the Experienced Gender When Pubertal Suspension Is Started in Early Puberty

Autor: Maria A T C van der Loos, Daniel T Klink, Martin den Heijer, Chantal M. Wiepjes, Mariska C. Vlot, Ilse Hellinga

Publikováno v: van der Loos, M A TC, Hellinga, I, Vlot, M C, Klink, D T, den Heijer, M & Wiepjes, C M 2021, ' Development of Hip Bone Geometry During Gender-Affirming Hormone Therapy in Transgender Adolescents Resembles That of the Experienced Gender When Pubertal Suspension Is Started in Early Puberty ', Journal of Bone and Mineral Research, vol. 36, no. 5, pp. 931-941 . https://doi.org/10.1002/jbmr.4262
Journal of Bone and Mineral Research, 36(5), 931-941. Wiley-Blackwell
Journal of Bone and Mineral Research

Bone geometry can be described in terms of periosteal and endocortical growth and is partly determined by sex steroids. Periosteal and endocortical apposition are thought to be regulated by testosterone and estrogen, respectively. Gender‐affirming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a008e307a887ce79d2821ee8bcf2e6e8
https://doi.org/10.1002/jbmr.4262

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Gender incongruence and gender dysphoria in childhood and adolescence—current insights in diagnostics, management, and follow-up

Autor: Chris M. Verhaak, Tim Middelberg, Joep Roeffen, Hedi Claahsen van der Grinten, Daniel T Klink, Thomas D. Steensma

Publikováno v: European Journal of Pediatrics
European Journal of Pediatrics, 180, 5, pp. 1349-1357
European Journal of Pediatrics, 180, 1349-1357
Claahsen-van der Grinten, H, Verhaak, C, Steensma, T, Middelberg, T, Roeffen, J & Klink, D 2021, ' Gender incongruence and gender dysphoria in childhood and adolescence—current insights in diagnostics, management, and follow-up ', European Journal of Pediatrics, vol. 180, no. 5, pp. 1349-1357 . https://doi.org/10.1007/s00431-020-03906-y

Gender incongruence (GI) is defined as a condition in which the gender identity of a person does not align with the gender assigned at birth. Awareness and more social acceptance have paved the way for early medical intervention about two decades ago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0953178fad2d48e9a7ba0c75bbf433ec
http://europepmc.org/articles/PMC8032627

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Akademický článek

Hypothalamic response to the chemo-signal androstadienone in gender dysphoric children and adolescents

Autor: Sarah M Burke, Peggy T Cohen-Kettenis, Dick eVeltman, Daniel T Klink, Julie eBakker

Publikováno v: Frontiers in Endocrinology, Vol 5 (2014)

The odorous steroid androstadienone, a putative male chemo-signal, was previously reported to evoke sex differences in hypothalamic activation in adult heterosexual men and women. In order to investigate whether puberty modulated this sex difference

Externí odkaz: https://doaj.org/article/136c79bdefb7412a9c5560f78b9b6c28

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Hormonal Treatment and Cardiovascular Risk Profile in Transgender Adolescents

Autor: Maartje Klaver, Renée de Mutsert, Maria A.T.C. van der Loos, Chantal M. Wiepjes, Jos W.R. Twisk, Martin den Heijer, Joost Rotteveel, Daniel T. Klink

BACKGROUND AND OBJECTIVES The effects of endocrinological treatment on cardiovascular risk profile in transgender adolescents are unknown. In this retrospective cohort study, we aim to investigate these effects and assess obesity and dyslipidemia pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18575b05552aee17abcfae078c01e08
https://doi.org/10.1542/9781610025423-hormonal

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Hormonal Treatment and Cardiovascular Risk Profile in Transgender Adolescents

Autor: Martin den Heijer, Renée de Mutsert, Maartje Klaver, Maria A T C van der Loos, Daniel T Klink, Chantal M. Wiepjes, Jos W. R. Twisk, Joost Rotteveel

Publikováno v: Klaver, M, de Mutsert, R, van der Loos, M A T C, Wiepjes, C M, Twisk, J W R, den Heijer, M, Rotteveel, J & Klink, D T 2020, ' Hormonal Treatment and Cardiovascular Risk Profile in Transgender Adolescents ', Pediatrics, vol. 145, no. 3, e20190741 . https://doi.org/10.1542/peds.2019-0741
Pediatrics, 145(3):e20190741. American Academy of Pediatrics
Pediatrics, 145(3). AMER ACAD PEDIATRICS

BACKGROUND AND OBJECTIVES: The effects of endocrinological treatment on cardiovascular risk profile in transgender adolescents are unknown. In this retrospective cohort study, we aim to investigate these effects and assess obesity and dyslipidemia pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f6adcbd27a1b17a00f2e599e08116
https://hdl.handle.net/1887/3184747

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Postnatal effects of sex hormones on click-evoked otoacoustic emissions: A study of adolescents with gender dysphoria

Autor: Jason O. van Heesewijk, Willeke M. Menks, Daniel T Klink, Baudewijntje P. C. Kreukels, Sarah M. Burke, P. T. Cohen-Kettenis, Julie Bakker

Publikováno v: Archives of Sexual Behavior, 49, 2, pp. 455-465
Archives of Sexual Behavior, 49, 455-465
Burke, S M, van Heesewijk, J O, Menks, W M, Klink, D T, Kreukels, B P C, Cohen-Kettenis, P T & Bakker, J 2020, ' Postnatal Effects of Sex Hormones on Click-Evoked Otoacoustic Emissions : A Study of Adolescents with Gender Dysphoria ', Archives of Sexual Behavior, vol. 49, no. 2, pp. 455-465 . https://doi.org/10.1007/s10508-020-01652-8
Archives of Sexual Behavior
Archives of Sexual Behavior, 49(2), 455-465. Springer New York

Contains fulltext : 216497.pdf (Publisher’s version ) (Open Access) Click-evoked otoacoustic emissions (CEOAEs) are echo-like sounds, generated by the inner ear in response to click-stimuli. A sex difference in emission strength is observed in neon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f1e1a635ef3fe2003e03f583762b0c
https://hdl.handle.net/2066/216497

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Development of Hip Bone Geometry in Transgender Adolescents Resembles the Experienced Gender if GnRHa Treatment Is Started in Early, but Not Late, Puberty

Autor: Maria A T C van der Loos, Daniel T Klink, Martin den Heijer, Chantal M. Wiepjes, Ilse Hellinga, Mariska C. Vlot

Publikováno v: Journal of the Endocrine Society

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309fb26087abd4dca72509199deb3e07
http://europepmc.org/articles/PMC8265905

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Lactosylated poly-l-lysine targets a potential lactose receptor in cystic fibrosis and non-cystic fibrosis airway epithelial cells

Autor: Qian-Chun Yu, Mary Catherine Glick, Daniel T. Klink, Thomas F. Scanlin

Publikováno v: Molecular Therapy. 7:73-80

Poly-L-lysine with 40% of the epsilon -amino groups substituted with lactosyl residues facilitated the internalization of lactosylated poly-L-lysine/cDNA complexes into cystic fibrosis (CF) and non-CF airway epithelial cells. It was previously shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1916ee6a78b3c7d2b7c214a4080d72e8
https://doi.org/10.1016/s1525-0016(02)00016-3

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[Untitled]

Autor: Mary Catherine Glick, Daniel T. Klink, Thomas F. Scanlin

Publikováno v: Glycoconjugate Journal. 18:731-740

Cystic fibrosis is a disease for which a number of Phase I clinical trials of gene therapy have been initiated. Several factors account for the high level of interest in a gene therapy approach to this disease. CF is the most common lethal inherited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b289ad76c1992442c1f0c952b369e23
https://doi.org/10.1023/a:1020879524587

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Nuclear translocation of lactosylated poly-L-lysine/cDNA complex in cystic fibrosis airway epithelial cells

Autor: Mary Catherine Glick, Daniel T. Klink, Thomas F. Scanlin, Simon Chao

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 3(6)

Poly-l-lysine, with 40% of its amino groups substituted with lactose, is an effective vector to transfer the CFTR gene into CF airway epithelial cells and correct the chloride channel dysfunction. The intracellular fate of the lactosylated poly-l-lys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d9db0bbc54598d46fdc95ae7dcb735
https://pubmed.ncbi.nlm.nih.gov/11407896

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