Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Daniel T. Dransfield"'
Autor:
Linah Al-Alem, Jillian M. Prendergast, Justin Clark, Bianca Zarrella, Dominique T. Zarrella, Sarah J. Hill, Whitfield B. Growdon, Venkatesh Pooladanda, David R. Spriggs, Daniel Cramer, Kevin M. Elias, Rawan I. Nazer, Steven J. Skates, Jeff Behrens, Daniel T. Dransfield, Bo R. Rueda
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-16 (2024)
Abstract Background Ovarian cancer remains the deadliest of the gynecologic cancers in the United States. There have been limited advances in treatment strategies that have seen marked increases in overall survival. Thus, it is essential to continue
Externí odkaz:
https://doaj.org/article/6ed8e2117ab34255a0bb41fc39805f9e
Autor:
Laetitia Devy, Shafaat A. Rabbani, Mark Stochl, Mary Ruskowski, Ian Mackie, Laurent Naa, Mark Toews, Reinoud van Gool, Jie Chen, Art Ley, Robert C. Ladner, Daniel T. Dransfield, Paula Henderikx
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 11, Pp 927-937 (2007)
Novel inhibitors of the urokinase-mediated plasminogen (plg) activation system are potentially of great clinical benefit as anticancer treatments. Using phage display, we identified DX-1000 a tissue factor pathway inhibitor-derived Kunitz domain prot
Externí odkaz:
https://doaj.org/article/0a325132c6214afb990dce9ee9823f24
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 5, Pp 441-448 (2000)
The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little toxicity. The antitumor effects of this compound are thought to involve its ability to modulate typ
Externí odkaz:
https://doaj.org/article/a7e77bd3b3824c93a409826a9dd69247
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 4, Pp 373-378 (1999)
The protein kinase A (PKA) is classified as type I or II depending on the association of the catalytic subunit with either the RI or RII regulatory subunits. Alterations in the levels of these regulatory subunits and PKA activity itself appear to aff
Externí odkaz:
https://doaj.org/article/66f355c5e5784ccba20af1189ce46487
Autor:
Laetitia Devy, Daniel T. Dransfield
Publikováno v:
Biochemistry Research International, Vol 2011 (2011)
MMP intervention strategies have met with limited clinical success due to severe toxicities. In particular, treatment with broad-spectrum MMP-inhibitors (MMPIs) caused musculoskeletal pain and inflammation. Selectivity may be essential for realizing
Externí odkaz:
https://doaj.org/article/06cf5881bfaf4ecfa4677a136c1db269
Autor:
Leah Cosgrove, Timothy E. Adams, Yan Huang, Greg Conley, Douglas Rank, Dina Wassaf, Diana Martik, Kris Kopacz, Niksa Kastrapeli, Gemma V. Brierley, Ilka Priebe, Tram Phan, Patricia A. Pilling, Janet Newman, Thomas S. Peat, Xiaowen Xiao, Olan Dolezal, John D. Bentley, Lindsay G. Sparrow, Qing Chang, Edward H. Cohen, Daniel T. Dransfield
Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6220c43728ee158f1e4761b040126ec5
https://doi.org/10.1158/1535-7163.22485011
https://doi.org/10.1158/1535-7163.22485011
Autor:
Leah Cosgrove, Timothy E. Adams, Yan Huang, Greg Conley, Douglas Rank, Dina Wassaf, Diana Martik, Kris Kopacz, Niksa Kastrapeli, Gemma V. Brierley, Ilka Priebe, Tram Phan, Patricia A. Pilling, Janet Newman, Thomas S. Peat, Xiaowen Xiao, Olan Dolezal, John D. Bentley, Lindsay G. Sparrow, Qing Chang, Edward H. Cohen, Daniel T. Dransfield
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenic signal through both IGF-IR and an alternately splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9990fdfadc29b2b4226f389d7d1c4acb
https://doi.org/10.1158/1535-7163.c.6531725
https://doi.org/10.1158/1535-7163.c.6531725
Autor:
Daniel T. Dransfield, Clive R. Wood, Maria Luisa Valentino, Shafaat A. Rabbani, Chris TenHoor, Paula Henderikx, Rene Hoet, Robert C. Ladner, Andrew E. Nixon, Sonia Schoonbroodt, Yu Lu Ma, Csaba Pazmany, Shannon Hogan, Douglas Rank, Guannan Kuang, Daniel J. Sexton, Reinoud van Gool, Annabelle Lejeune, Marc Vanhove, Qingfeng Tao, Edward Chang, Nicolas Frans, Henk Pieters, Niranjan Yanamandra, Laurent Naa, Lili Huang, Laetitia Devy
Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ad90f85bac4e1357eb214667eadf37f
https://doi.org/10.1158/0008-5472.c.6499896.v1
https://doi.org/10.1158/0008-5472.c.6499896.v1
Autor:
Daniel T. Dransfield, Clive R. Wood, Maria Luisa Valentino, Shafaat A. Rabbani, Chris TenHoor, Paula Henderikx, Rene Hoet, Robert C. Ladner, Andrew E. Nixon, Sonia Schoonbroodt, Yu Lu Ma, Csaba Pazmany, Shannon Hogan, Douglas Rank, Guannan Kuang, Daniel J. Sexton, Reinoud van Gool, Annabelle Lejeune, Marc Vanhove, Qingfeng Tao, Edward Chang, Nicolas Frans, Henk Pieters, Niranjan Yanamandra, Laurent Naa, Lili Huang, Laetitia Devy
Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362235aff74f4e94e6209bb11bdd0a07
https://doi.org/10.1158/0008-5472.22381518.v1
https://doi.org/10.1158/0008-5472.22381518.v1
Autor:
Daniel T. Dransfield, Clive R. Wood, Maria Luisa Valentino, Shafaat A. Rabbani, Chris TenHoor, Paula Henderikx, Rene Hoet, Robert C. Ladner, Andrew E. Nixon, Sonia Schoonbroodt, Yu Lu Ma, Csaba Pazmany, Shannon Hogan, Douglas Rank, Guannan Kuang, Daniel J. Sexton, Reinoud van Gool, Annabelle Lejeune, Marc Vanhove, Qingfeng Tao, Edward Chang, Nicolas Frans, Henk Pieters, Niranjan Yanamandra, Laurent Naa, Lili Huang, Laetitia Devy
Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202e975447b6fb0d17af004056b1b698
https://doi.org/10.1158/0008-5472.22381515
https://doi.org/10.1158/0008-5472.22381515