Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Daniel T. Chu"'
Autor:
Daniel T. Chu, Alice Rico, Ribhi Shawar, Manoj C. Desai, Lynn Barker, J. J. Plattner, Georgia Law Carroll, Xiaodong Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4692-4696
Synthesis of C12 des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C12 stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cdcafc6dafee4b92833738641173cd
https://doi.org/10.1016/j.bmcl.2006.05.104
https://doi.org/10.1016/j.bmcl.2006.05.104
Autor:
Lynn Barker, Mike Langhorne, Mehran Seid, Ribhi Shawar, J. J. Plattner, Burger Matthew, Jolene Kidney, Christy Hiebert, Manoj C. Desai, Daniel T. Chu
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5592-5604
A novel series of C(12) ethyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens, including those resistant to erythromycin. The C(12) modification involves replacing the natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0e8ba17b7902ccd0c1c3f87e80ab2b
https://doi.org/10.1016/j.bmc.2006.04.032
https://doi.org/10.1016/j.bmc.2006.04.032
Publikováno v:
ChemInform. 32
A ketolide was prepared from 14,15-dehydroerythromycin A by two different routes. The first approach involving oxidation of the 3-OH of 3-descladinosyl-14,15-dehydroerythromycin A 2'-O-acetate gave unexpectedly high levels of 3,11-double oxidation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d2e3acec8023fbfb6531b01cfc25e81
https://doi.org/10.1002/chin.200134239
https://doi.org/10.1002/chin.200134239
Autor:
A.B. Jefferson, Jeremy Murray, Xiaodong Lin, Sylvia Ma, Daniel T. Chu, Michael X. Wang, Kenneth A. Crawford, Yasheen Zhou, Susan E. Kaufman, Merci Del Rosario, Alice Rico, Eric Fang
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(16)
A series of 2-pyrimidyl-5-amidothiophenes has been synthesized and evaluated for AKT inhibition. SAR studies resulted in potent inhibitors of AKT with IC(50) values as low as single digit nanomolar as represented by compound 2aa. Compound 2aa showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b57f571be516ac349dff43b517469e
https://pubmed.ncbi.nlm.nih.gov/16765046
https://pubmed.ncbi.nlm.nih.gov/16765046
Autor:
Daniel T. Chu, Mike Langhorne, Kelly Young, Christy Hiebert, Jolene Kidney, J. J. Plattner, Scott Anderson, Georgia Law Carroll, Kay Huh, Mehran Seid, Xiaodong Lin, Alice Rico, Manoj C. Desai, Lynn Barker, Ribhi Shawar, Burger Matthew
Publikováno v:
Journal of medicinal chemistry. 49(5)
A novel series of C12 vinyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens. The C12 modification involves replacing the natural C12 methyl group in the erythromycin core with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97c1aea270b45408d271b0571b25618
https://pubmed.ncbi.nlm.nih.gov/16509588
https://pubmed.ncbi.nlm.nih.gov/16509588
Publisher Summary Recent advances in rapid gene cloning, polymerase chain reaction (PCR)-based gene amplification and DNA sequencing technologies, along with associated sophisticated analysis software, have made bacterial genome sequencing both pract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d897ab1a4dfa6ff12977094b50921463
https://doi.org/10.1016/s0065-7743(08)61470-0
https://doi.org/10.1016/s0065-7743(08)61470-0
Autor:
Daniel T. Chu, Kohji Maeda
Publikováno v:
Analytical Sciences. 20:1621-1621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092ac79c29aa9976a83798e5120711a5
https://doi.org/10.2116/analsci.20.1621
https://doi.org/10.2116/analsci.20.1621