Výsledky vyhledávání - "Daniel T S Pak"

Akademický článek

Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.

Autor: Ji Soo Lee, Yeunkum Lee, Emily A André, Kea Joo Lee, Thien Nguyen, Yang Feng, Nuo Jia, Brent T Harris, Mark P Burns, Daniel T S Pak

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0219691 (2019)

Alzheimer disease (AD) is a neurodegenerative disorder characterized by pathological hallmarks of neurofibrillary tangles and amyloid plaques. The plaques are formed by aggregation and accumulation of amyloid β (Aβ), a cleavage fragment of amyloid

Externí odkaz: https://doaj.org/article/b0d48a1faca6491aa3a94774c3fdeacf

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Akademický článek

Wherefore Art Thou, Homeo(stasis)? Functional Diversity in Homeostatic Synaptic Plasticity

Autor: Bridget N. Queenan, Kea Joo Lee, Daniel T. S. Pak

Publikováno v: Neural Plasticity, Vol 2012 (2012)

Homeostatic plasticity has emerged as a fundamental regulatory principle that strives to maintain neuronal activity within optimal ranges by altering diverse aspects of neuronal function. Adaptation to network activity is often viewed as an essential

Externí odkaz: https://doaj.org/article/4189405e264e453fa519e445217db022

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Akademický článek

ApoE receptor 2 regulates synapse and dendritic spine formation.

Autor: Sonya B Dumanis, Hyun-Jung Cha, Jung Min Song, Justin H Trotter, Matthew Spitzer, Ji-Yun Lee, Edwin J Weeber, R Scott Turner, Daniel T S Pak, G William Rebeck, Hyang-Sook Hoe

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17203 (2011)

Apolipoprotein E receptor 2 (ApoEr2) is a postsynaptic protein involved in long-term potentiation (LTP), learning, and memory through unknown mechanisms. We examined the biological effects of ApoEr2 on synapse and dendritic spine formation-processes

Externí odkaz: https://doaj.org/article/746b792ebb2b4594be3396e2f48cfa3a

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