Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Daniel T Cohen"'
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3229-3239.e6 (2020)
Summary: BCL-2 family proteins converge at the mitochondrial outer membrane to regulate apoptosis and maintain the critical balance between cellular life and death. This physiologic process is essential to organism homeostasis and relies on protein-p
Externí odkaz:
https://doaj.org/article/d674418a0a83428c96204962babe54c6
Autor:
Kyle A. Totaro, Daniel T. Cohen, Yuki Hirata, Zachary P. Gates, Bradley L. Pentelute, Daniel L. Dunkelmann, Chi Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3752-3757
The facile rearrangement of “ S -acyl isopeptides” to native peptide bonds via S , N -acyl shift is central to the success of native chemical ligation, the widely used approach for protein total synthesis. Proximity-driven amide bond formation vi
Autor:
Daniel T. Cohen, Silvia Escudero, Catherine G Gallagher, Thomas E. Wales, John R. Engen, Loren D. Walensky, Susan Lee, Annissa J. Huhn, Nicole A. Cohen, James Luccarelli, Gregory H. Bird
Publikováno v:
Nature structural & molecular biology
MCL-1 is an antiapoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer. Like BCL-2, MCL-1 bears a surface groove whose function is to sequester the BH3 killer domains of proapoptotic BCL-2 family members, a mecha
Publikováno v:
Chemical Communications. 51:2690-2693
An unusual room temperature β-lactone decarboxylation facilitated a five-step enantioselective formal synthesis of the cyclopentane core of an estrogen receptor β-agonist. A computational study probed the underlying factors facilitating unprecedent
The Armillaria and Lactarius genera of fungi produce the antimicrobial and cytotoxic mellolide, protoilludane, and marasmane sesquiterpenoids. We report a unified synthetic strategy to access the protoilludane, mellolide, and marasmane families of na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa64421cefef7491bc53d65f808adcdf
https://europepmc.org/articles/PMC5682929/
https://europepmc.org/articles/PMC5682929/
Autor:
Audrey Chan, Karl A. Scheidt, Matthias Riedrich, Daniel T. Cohen, Rama K. Mishra, Brooks E. Maki, Michael H. Wang, David N. Barsoum, C. Benjamin Schwamb, Brian C. Goess
Publikováno v:
The Journal of organic chemistry. 82(9)
The NHC-catalyzed transformation of unsaturated aldehydes into saturated esters through an organocatalytic homoenolate process has been thoroughly studied. Leveraging a unique "Umpolung"-mediated β-protonation, this process has evolved from a test b
Autor:
Daniel T Cohen, Geeta Watal, Teresa Snyder-Leiby, PuiYee Chan, Sarah Gibbons, Prashant Kumar Rai, E. R. Dickstein, Fadi Khawam, Preeti Dhar
Publikováno v:
Journal of Agricultural and Food Chemistry. 62:3548-3552
Several (+)- and (-)-α-pinene derivatives were synthesized and evaluated for their antimicrobial activity toward Gram-positive bacteria Micrococcus luteus and Staphylococcus aureus, Gram-negative bacterium Escherichia coli, and the unicellular fungu
Autor:
Gregory J. Heffron, Jonathan R. Pritz, John R. Engen, Thomas E. Wales, Daniel T. Cohen, Susan Lee, Franziska Wachter, Walter Massefski, James Luccarelli, Paul Coote, Loren D. Walensky
Publikováno v:
Nature chemical biology
BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conduc
Publikováno v:
Angewandte Chemie. 124:11854-11866
Katalytische Umwandlungen mit N-heterocyclischen Carbenen (NHCs) haben sich als effiziente Ansatze zum Aufbau komplexer Molekule erwiesen. Seit der Veroffentlichung von Stetter 1975 zur Totalsynthese von cis-Jasmon und Dihydrojasmon durch Carbenkatal
Autor:
Julien Dugal-Tessier, Elizabeth A. O'Bryan, Daniel T. Cohen, Karl A. Scheidt, Thomas Schroeder
Publikováno v:
Angewandte Chemie International Edition. 51:4963-4967
A cooperative catalysis approach for the enantioselective formal [3+2] addition of α,β-unsaturated aldehydes to isatins has been developed. The N-heterocyclic carbene (NHC)-catalyzed homoenolate annulations of β-aryl enals require the addition of