Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Daniel T, Meier"'
Autor:
Kaisa Hofwimmer, Joyce de Paula Souza, Narmadha Subramanian, Milica Vujičić, Leila Rachid, Hélène Méreau, Cheng Zhao, Erez Dror, Emelie Barreby, Niklas K. Björkström, Ingrid Wernstedt Asterholm, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Y. Donath, Jurga Laurencikiene
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1
Externí odkaz:
https://doaj.org/article/ba5db9b693c1401681bcd5953d8aed76
Autor:
Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Zora Baumann, Neena Parayil, Faiza Noreen, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background We previously found that air pollution particles reaching the gastrointestinal tract elicit gut inflammation as shown by up-regulated gene expression of pro-inflammatory cytokines and monocyte/macrophage markers. This inflammatory
Externí odkaz:
https://doaj.org/article/bb847b6aea4a4d6d8971b636af85b7af
Autor:
Laura Steiger, Zora Baumann, Lena Keller, Marianne Böni-Schnetzler, Marc Y. Donath, Daniel T. Meier
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102664- (2023)
Summary: Diabetes mellitus is a disease of the hormone-secreting endocrine pancreas. However, increasing evidence suggests that the exocrine pancreas is also involved in the pathogenesis of diabetes. In this protocol, we describe how to harvest both
Externí odkaz:
https://doaj.org/article/a4adfa6dee714ee5bc7936496ec3c8fc
Autor:
Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Lena Keller, Zora Baumann, Neena Parayil, Marc Stawiski, Leila Rachid, Thomas Dervos, Sandra Mitrovic, Daniel T. Meier, Claudia Cavelti-Weder
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Air pollution has emerged as an unexpected risk factor for diabetes. However, the mechanism behind remains ill-defined. So far, the lung has been considered as the main target organ of air pollution. In contrast, the gut has recei
Externí odkaz:
https://doaj.org/article/69c058265092496881f3beb53d3725e0
Autor:
Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V. Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y. Donath
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Defective insulin secretion is observed early in the development of diabetes. Here the authors report that β cell-specific deficiency of the insulin prohormone convertase 1/3 (PC1/3) leads not only to hyperglycemia, but also to hyperphagic obesity i
Externí odkaz:
https://doaj.org/article/c2d52d524de146cb95b1f820a6251d26
Autor:
Theresa V. Rohm, Lena Keller, Angela J. T. Bosch, Shefaa AlAsfoor, Zora Baumann, Amandine Thomas, Sophia J. Wiedemann, Laura Steiger, Elise Dalmas, Josua Wehner, Leila Rachid, Catherine Mooser, Bahtiyar Yilmaz, Nerea Fernandez Trigo, Annaise J. Jauch, Stephan Wueest, Daniel Konrad, Sandrine Henri, Jan H. Niess, Petr Hruz, Stephanie C. Ganal-Vonarburg, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the
Externí odkaz:
https://doaj.org/article/80b59b6deb3e496981cc210ada5bc2b9
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291950 (2023)
System xc-, encoded by Slc7a11, is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzym
Externí odkaz:
https://doaj.org/article/624534ec57cb4bd6ad03c03c180b9620
Autor:
Marianne Böni-Schnetzler, Hélène Méreau, Leila Rachid, Sophia J. Wiedemann, Friederike Schulze, Kelly Trimigliozzi, Daniel T. Meier, Marc Y. Donath
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103250- (2021)
Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreas
Externí odkaz:
https://doaj.org/article/8c210037d7104ffebcadf66383ce7f6c
Autor:
Marianne Böni-Schnetzler, Stéphanie P. Häuselmann, Elise Dalmas, Daniel T. Meier, Constanze Thienel, Shuyang Traub, Friederike Schulze, Laura Steiger, Erez Dror, Praxedis Martin, Pedro L. Herrera, Cem Gabay, Marc Y. Donath
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1774-1786 (2018)
Summary: Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β
Externí odkaz:
https://doaj.org/article/57e70e42c68f4540a15c19f5916584e6
Autor:
Shuyang Traub, Daniel T. Meier, Friederike Schulze, Erez Dror, Thierry M. Nordmann, Nicole Goetz, Norina Koch, Elise Dalmas, Marc Stawiski, Valmir Makshana, Fabrizio Thorel, Pedro L. Herrera, Marianne Böni-Schnetzler, Marc Y. Donath
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3192-3203 (2017)
Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin sec
Externí odkaz:
https://doaj.org/article/bf5e8dc8466046d0b86cc1980531f5c0