Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Daniel T, Connolly"'
Autor:
Heidi Rath Hope, Deborah Heuvelman, Kevin Duffin, Christine Smith, Jeffery Zablocki, Roger Schilling, Shridhar Hegde, Len Lee, Bryan Witherbee, Mark Baganoff, Can Bruce, Alan R. Tall, Elaine Krul, Kevin Glenn, Daniel T. Connolly
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 10, Pp 1604-1614 (2000)
SC-71952, a substituted analog of dithiobisnicotinic acid dimethyl ester, was identified as a potent inhibitor of cholesteryl ester transfer protein (CETP). When tested in an in vitro assay, the concentration of SC-71952 required for half-maximal inh
Externí odkaz:
https://doaj.org/article/cc5033ac3088478fbe63f90dab676d71
Autor:
Jerry Xu, Milton L. Hammond, Brett Lauring, James R. Tata, Philip J. Skinner, Jens Knudsen, Daniel T. Connolly, Eseng Lai, Graeme Semple, Wen-Lin Luo, M. Gerard Waters, P. Douglas Boatman, John A. Wagner, Martin C. Cherrier, Jae-Kyu Jung, Steven L. Colletti, Andrew K.P. Taggart, Ester Carballo-Jane, Ruoping Chen, Benjamin R. Johnson, Thomas O. Schrader, Josee Cote, Carleton R. Sage, Luzelena Caro, Jeremy G. Richman, Michelle Kasem, Peter J. Webb
Publikováno v:
Journal of Medicinal Chemistry. 55:3644-3666
G-protein coupled receptor (GPCR) GPR109a is a molecular target for nicotinic acid and is expressed in adipocytes, spleen, and immune cells. Nicotinic acid has long been used for the treatment of dyslipidemia due to its capacity to positively affect
Autor:
P. Douglas Boatman, Huong T. Dang, Adams John W, Daniel T. Connolly, Zhuangjie Li, Chen W. Liaw, Ruoping Chen, Thuy-Anh Tran, Tong Zhang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H299-H311
The Mas receptor is a class I G-protein-coupled receptor that is expressed in brain, testis, heart, and kidney. The intracellular signaling pathways activated downstream of Mas are still largely unknown. In the present study, we examined the expressi
Autor:
Dominic P. Behan, Karin Lehmann-Bruinsma, Thuy Le, Yaron Hakak, Chen W. Liaw, Daniel T. Connolly, Shirley Phillips
Publikováno v:
Journal of Leukocyte Biology. 85:837-843
Regulation of cellular metabolism by the citric acid cycle occurs in the mitochondria. However, the citric acid cycle intermediate succi- nate was shown recently to be a ligand for the G-protein-coupled receptor GPR91. Here, we de- scribe a role for
Autor:
Daniel T. Connolly, Yale B. Mitchel, Larissa Wenning, M. Gerard Waters, Amy O. Johnson-Levonas, John F. Paolini, Eseng Lai, Inna Perevozskaya, Wei Zheng, Waldemar Radziszewski, Graeme Semple, James R. Tata, John A. Wagner
Publikováno v:
Journal of Clinical Lipidology. 2:375-383
Background Development of niacin-like agents that favorably affect lipids with an improved flushing profile would be beneficial. Objective To evaluate a niacin receptor partial agonist, MK-0354, in Phase I and II studies. Methods The pharmacokinetic/
Autor:
Peter I. Dosa, Yunqing Shi, Bradley Teegarden, Hussien A. Al-Shamma, Dominic P. Behan, John W. Adams, Michael Morgan, Jeremy G. Richman, William Thomsen, Daniel T. Connolly, Juan Ramirez, Danny Ortuno
Publikováno v:
European Journal of Pharmacology. 586:234-243
We have evaluated the anti-platelet and vascular pharmacology of AR246686, a novel 5-hydroxytryptamine2A (5-HT2A) receptor antagonist. AR246686 displayed high affinity binding to membranes of HEK cells stably expressing recombinant human and rat 5-HT
Autor:
Huong T. Dang, Philip J. Skinner, Graeme Semple, Martin C. Cherrier, Peter J. Webb, Ruoping Chen, Susan Y. Tamura, Carleton R. Sage, Daniel T. Connolly, Cameron Pride, Jeremy G. Richman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6619-6622
A series of 3-nitro-4-substituted-aminobenzoic acids were prepared and found to act as potent and highly selective agonists of the orphan human GPCR GPR109b, a low affinity receptor for niacin. No activity was observed at the closely homologous high
Autor:
Philip J. Skinner, Tawfik Gharbaoui, Vu Hong, Ruoping Chen, Graeme Semple, Huong T. Dang, Martin C. Cherrier, Jeremy G. Richman, Young-Jun Shin, Cameron Pride, Peter J. Webb, Andrew K. Lindstrom, Daniel T. Connolly, Susan Y. Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5620-5623
A series of 5-alkyl pyrazole-3-carboxylic acids were prepared and found to act as potent and selective agonists of the human GPCR, GPR109a, the high affinity nicotinic acid receptor. No activity was observed at the highly homologous low affinity niac
Autor:
Yaron Hakak, Ibragim Gaidarov, Dominic P. Behan, Jeremy G. Richman, Dominique Maciejewski-Lenoir, Daniel T. Connolly
Publikováno v:
Journal of Investigative Dermatology. 126:2637-2646
Nicotinic acid, used for atherosclerosis treatment, has an adverse effect of skin flushing. The flushing mechanism, thought to be caused by the release of prostaglandin D(2) (PGD(2)), is not well understood. We aimed to identify which cells mediate t
Autor:
Peter J. Webb, Martin C. Cherrier, Graeme Semple, Carleton R. Sage, Philip J. Skinner, Jeremy G. Richman, Ruoping Chen, Susan Y. Tamura, Daniel T. Connolly
Publikováno v:
Journal of Medicinal Chemistry. 49:1227-1230
1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-raising drug niac