The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+ -Aβ Complex

Autor: Lars Hemmingsen, Susanne Mossin, Kasper Planeta Kepp, Jingdong Zhang, Kaare Teilum, Daniel Szunyogh, Peter M. Søtofte, Morten J. Bjerrum, Fei Shen, Arun Kumar Somavarapu, Manish Kumar Tiwari, Peter W. Thulstrup

Publikováno v: Somavarapu, A K, Shen, F, Teilum, K, Zhang, J, Mossin, S, Thulstrup, P W, Bjerrum, M J, Tiwari, M K, Szunyogh, D, Søtofte, P M, Kepp, K P & Hemmingsen, L 2017, ' The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu 2+-Aβ Complex ', Chemistry-A European Journal, vol. 23, no. 55, pp. 13591-13595 . https://doi.org/10.1002/chem.201703440

A prominent current hypothesis is that impaired metal ion homeostasis may contribute to Alzheimer's disease (AD). We elucidate the interaction of Cu2+ with wild-type (WT) Aβ1–40 and the genetic variants A2T and A2V which display increasing pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b502851f48ec0f7045e9ab592409b323
https://doi.org/10.1002/chem.201703440

A reference compound for 199mHg perturbed angular correlation of γ-rays spectroscopy

Autor: Marianne L. Jensen, Daniel Szunyogh, Attila Jancsó, Peter W. Thulstrup, Lars Hemmingsen, J. G. Correia, Juliana Schell, Ria K. Balogh

Publikováno v: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 1002:165154

199m Hg is a very useful probe for perturbed angular correlation of γ -rays (PAC) spectroscopy . Here we present 199m Hg PAC data for a Hg 2 + containing compound, Hg(Cys)2 (s), giving one unique nuclear quadrupole interaction (NQI). Four separate s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::309aa838472eca6aacefee40ea50f5fa
https://doi.org/10.1016/j.nima.2021.165154

Direct observation of Mg2+ complexes in ionic liquid solutions by 31Mg β-NMR spectroscopy

Autor: Ruohong Li, Gerald D. Morris, Victoria L. Karner, Iain McKenzie, Lars Hemmingsen, Evan Kallenberg, S. Pallada, W. Andrew MacFarlane, Derek Fujimoto, Paul Schaffer, Lia Formenti, Ryan M. L. McFadden, Monika Stachura, A. Gottberg, Stephan P. A. Sauer, Matthew Pearson, Jens Lassen, C. D. Philip Levy, Aris Chatzichristos, Flemming H. Larsen, Daniel Szunyogh, Thomas Day Goodacre, Robert F. Kiefl, Peter W. Thulstrup, Ildikó Kálomista, M. H. Dehn

Publikováno v: Szunyogh, D, McFadden, R M L, Karner, V L, Chatzichristos, A, Day Goodacre, T, Dehn, M H, Formenti, L, Fujimoto, D, Gottberg, A, Kallenberg, E, Kálomista, I, Kiefl, R F, Larsen, F H, Lassen, J, Levy, C D P, Li, R, Macfarlane, W A, McKenzie, I, Morris, G D, Pallada, S, Pearson, M R, Sauer, S P A, Schaffer, P, Thulstrup, P W, Hemmingsen, L B S & Stachura, M 2018, ' Direct observation of Mg 2+ complexes in ionic liquid solutions by 31 Mg β-NMR spectroscopy ', Dalton Transactions, vol. 47, no. 41, pp. 14431-14435 . https://doi.org/10.1039/c8dt02350f

NMR spectra of Mg2+ ions in ionic liquids were recorded using a highly sensitive variant of NMR spectroscopy known as β-NMR. The β-NMR spectra of MgCl2 in EMIM-Ac and EMIM-DCA compare favourably with conventional NMR, and exhibit linewidths of ∼3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b6475b2dcf644938b8ea93d6b22d26
https://curis.ku.dk/portal/da/publications/direct-observation-of-mg2-complexes-in-ionic-liquid-solutions-by-31mg-nmr-spectroscopy(683bc48f-7322-4722-b813-b7aa8fb419c4).html

TDPAC and β -NMR applications in chemistry and biochemistry

Autor: S. Pallada, Doru C. Lupascu, Lars Hemmingsen, Magdalena Kowalska, Monika Stachura, A. Gottberg, J. G. Correia, Daniel Szunyogh, Attila Jancsó, Juliana Schell

Publikováno v: Journal of Physics G: Nuclear and Particle Physics
Jancso, A, Correia, J G, Gottberg, A, Schell, J, Stachura, M, Szunyogh, D M, Pallada, S, Lupascu, D C, Kowalska, M & Hemmingsen, L B S 2017, ' TDPAC and β-NMR applications in chemistry and biochemistry ', Journal of Physics G: Nuclear and Particle Physics, vol. 44, no. 6, 064003 . https://doi.org/10.1088/1361-6471/aa666b

Time differential perturbed angular correlation (TDPAC) of γ-rays spectroscopy has been applied in chemistry and biochemistry for decades. Herein we aim to present a comprehensive review of chemical and biochemical applications of TDPAC spectroscopy

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Metal ion interaction of an oligopeptide fragment representing the regulatory metal binding site of a CueR protein

Autor: Attila Jancsó, Hajnalka Szokolai, Livia Roszahegyi, Daniel Szunyogh, Lars Hemmingsen, Peter Waaben Thulstrup, Flemming Hofmann Larsen

Publikováno v: University of Copenhagen
Jancsó, A, Szokolai, H, Roszahegyi, L, Szunyogh, D, Hemmingsen, L B S, Thulstrup, P W & Larsen, F H 2013, ' Metal ion interaction of an oligopeptide fragment representing the regulatory metal binding site of a CueR protein ' .
Publons

Metalloregulatory proteins of the MerR family are transcriptional activatorsthat sense/control the concentration of various metal ions inside bacteria.1The Cu+ efflux regulator CueR, similarly to other MerR proteins, possesses ashort multiple Cys-con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5f0f2a5a81dd3803ef032ccef07132c8
https://curis.ku.dk/portal/en/publications/metal-ion-interaction-of-an-oligopeptide-fragment-representing-the-regulatory-metal-binding-site-of-a-cuer-protein(ab106659-a248-4861-bdbc-3b49f4a5fabf).html