Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Daniel Suveges"'
Autor:
Karoline Kuchenbaecker, Arthur Gilly, Daniel Suveges, Lorraine Southam, Olga Giannakopoulou, Britt Kilian, Emmanouil Tsafantakis, Maria Karaleftheri, Aliki-Eleni Farmaki, Deepti Gurdasani, Kousik Kundu, Manjinder S. Sandhu, John Danesh, Adam Butterworth, Inês Barroso, George Dedoussis, Eleftheria Zeggini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Haematological traits are linked to cardiovascular, metabolic, infectious and immune disorders, as well as cancer. Here, we examine the role of genetic variation in shaping haematological traits in two isolated Mediterranean populations. Usi
Externí odkaz:
https://doaj.org/article/70aaa5db29d7427d950b9acb498c295b
Autor:
Tewodros Gebresilase, Chris Finan, Daniel Suveges, Tesfaye Sisay Tessema, Abraham Aseffa, Gail Davey, Konstantinos Hatzikotoulas, Eleftheria Zeggini, Melanie J. Newport, Fasil Tekola-Ayele
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Podoconiosis, a debilitating lymphoedema of the leg, results from barefoot exposure to volcanic clay soil in genetically susceptible individuals. A previous genome-wide association study (GWAS) conducted in the Wolaita ethnic group from Ethi
Externí odkaz:
https://doaj.org/article/62fdc6fa44c241f094368907be57e630
Autor:
Arthur Gilly, Young-Chan Park, Grace Png, Andrei Barysenka, Iris Fischer, Thea Bjørnland, Lorraine Southam, Daniel Suveges, Sonja Neumeyer, N. William Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the
Externí odkaz:
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
Autor:
Arthur Gilly, Daniel Suveges, Karoline Kuchenbaecker, Martin Pollard, Lorraine Southam, Konstantinos Hatzikotoulas, Aliki-Eleni Farmaki, Thea Bjornland, Ryan Waples, Emil V. R. Appel, Elisabetta Casalone, Giorgio Melloni, Britt Kilian, Nigel W. Rayner, Ioanna Ntalla, Kousik Kundu, Klaudia Walter, John Danesh, Adam Butterworth, Inês Barroso, Emmanouil Tsafantakis, George Dedoussis, Ida Moltke, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Rare genetic variants can contribute to complex traits but this contribution is not well understood. Here, the authors analyse deep whole genome sequencing data across 1457 individuals from an isolated Greek population and find association of rare va
Externí odkaz:
https://doaj.org/article/21e7f8a5a81c4b47a35814b4882daaea
Autor:
Arthur Gilly, Daniel Suveges, Karoline Kuchenbaecker, Martin Pollard, Lorraine Southam, Konstantinos Hatzikotoulas, Aliki-Eleni Farmaki, Thea Bjornland, Ryan Waples, Emil V. R. Appel, Elisabetta Casalone, Giorgio Melloni, Britt Kilian, Nigel W. Rayner, Ioanna Ntalla, Kousik Kundu, Klaudia Walter, John Danesh, Adam Butterworth, Inês Barroso, Emmanouil Tsafantakis, George Dedoussis, Ida Moltke, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in Fig. 2. In panel a, the two legend items “rare” and “common” were inadvertently swapped. This has been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/3f03351ffa1d41319a18f78d865541ed
Autor:
David Ochoa, Andrew Hercules, Miguel Carmona, Daniel Suveges, Jarrod Baker, Cinzia Malangone, Irene Lopez, Alfredo Miranda, Carlos Cruz-Castillo, Luca Fumis, Manuel Bernal-Llinares, Kirill Tsukanov, Helena Cornu, Konstantinos Tsirigos, Olesya Razuvayevskaya, Annalisa Buniello, Jeremy Schwartzentruber, Mohd Karim, Bruno Ariano, Ricardo Esteban Martinez Osorio, Javier Ferrer, Xiangyu Ge, Sandra Machlitt-Northen, Asier Gonzalez-Uriarte, Shyamasree Saha, Santosh Tirunagari, Chintan Mehta, Juan María Roldán-Romero, Stuart Horswell, Sarah Young, Maya Ghoussaini, David G Hulcoop, Ian Dunham, Ellen M McDonagh
Publikováno v:
Nucleic Acids Research. 51:D1353-D1359
The Open Targets Platform (https://platform.opentargets.org/) is an open source resource to systematically assist drug target identification and prioritisation using publicly available data. Since our last update, we have reimagined, redesigned, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dffeff31dcc4de4b454719a05269273
https://doi.org/10.1093/nar/gkac1046
https://doi.org/10.1093/nar/gkac1046
Autor:
Inigo Barrio-Hernandez, Jeremy Schwartzentruber, Anjali Shrivastava, Noemi del-Toro, Asier Gonzalez, Qian Zhang, Edward Mountjoy, Daniel Suveges, David Ochoa, Maya Ghoussaini, Glyn Bradley, Henning Hermjakob, Sandra Orchard, Ian Dunham, Carl A. Anderson, Pablo Porras, Pedro Beltrao
Publikováno v:
Nature Genetics, 55 (3)
Interacting proteins tend to have similar functions, influencing the same organismal traits. Interaction networks can be used to expand the list of candidate trait-associated genes from genome-wide association studies. Here, we performed network-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83c627d04041e4fc3c3bbe9f7b3a34
Autor:
Grace Png, Emmanouil Tsafantakis, Iris Fischer, N. William Rayner, Daniel Suveges, George Dedoussis, Andrei Barysenka, Arthur Gilly, Sonja Neumeyer, Lorraine Southam, Thea Bjørnland, Maria Karaleftheri, Young-Chan Park, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571b46eb8d5837c975f58d0af3d41717
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
Autor:
Asier Gonzalez-Uriarte, Paola Roncaglia, Helen Parkinson, Ellen M. McDonagh, Denise Carvalho-Silva, Jeffrey C. Barrett, Cinzia Malangone, Maya Ghoussaini, Eliseo Papa, James D. Hayhurst, Zoë May Pendlington, Andrew Hercules, Simon Jupp, Ian Dunham, Edward Mountjoy, Ellen M. Schmidt, Annalisa Buniello, Javier Ferrer, Mohd Anisul Karim, Gautier Koscielny, Olga Vrousgou, Daniel Wright, Daniel Suveges, Gareth Peat, David G. Hulcoop, Alfredo Miranda, Tony Burdett, Miguel Carmona, David Ochoa, Jeremy Schwartzentruber, Luca Fumis, John A. Todd, Jacqueline A. L. MacArthur, Jarrod Baker, Sandra Machlitt-Northen
Publikováno v:
Nucleic Acids Research
Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction and conformation data from a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68993856a69cde406777188f394460a
http://europepmc.org/articles/PMC7778936
http://europepmc.org/articles/PMC7778936
Autor:
Ellen M. McDonagh, Denise Carvalho-Silva, Jeremy Schwartzentruber, Adam Faulconbridge, Asier Gonzalez-Uriarte, Michaela Spitzer, Ian Dunham, Eliseo Papa, Elaine McAuley, David Ochoa, Luca Fumis, Chuang Kee Ong, Andrea Pierleoni, Daniel Suveges, Jarrod Baker, Andrew Hercules, Gareth Peat, Edward Mountjoy, Eirini Petsalaki, Prudence Mutowo, Miguel Carmona, Gautier Koscielny, Miguel Pignatelli, David G. Hulcoop, Olesya Razuvayevskaya, Sandra Machlitt-Northen, Cinzia Malangone, Javier Ferrer, Mohd Anisul Karim, Maya Ghoussaini, Alfredo Miranda, Arwa Bin Raies
Publikováno v:
Nucleic Acids Research
The Open Targets Platform (https://www.targetvalidation.org/) provides users with a queryable knowledgebase and user interface to aid systematic target identification and prioritisation for drug discovery based upon underlying evidence. It is publicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2664c3a844cec920089d5e95389b51c2
https://pubmed.ncbi.nlm.nih.gov/33196847
https://pubmed.ncbi.nlm.nih.gov/33196847