Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel Staudenraus"'
Autor:
Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler, Evelyn Ullrich
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTInterferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4+ T cells abr
Externí odkaz:
https://doaj.org/article/0e061017555b4bc0b1aa91d36567a9dd
Publikováno v:
European Journal of Immunology. 52:1680-1683
IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8105ca8a48a127db7f8c68132272150
https://doi.org/10.1002/eji.202249869
https://doi.org/10.1002/eji.202249869
Autor:
Alexander Visekruna, Ulrich Steinhoff, Markus Bosmann, Bernd Schmeck, Wilhelm Bertrams, Leon N. Schulte, Nils Schmerer, Arjun Sharma, Hans-Joachim Mollenkopf, Aleksandra Lopez Krol, Daniel Staudenraus, Maik Luu, Hanna Leister
Supplementary Figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e79165f16ec57e3632c2ad4a331fb88
https://doi.org/10.1158/2326-6066.22543144
https://doi.org/10.1158/2326-6066.22543144
Autor:
Alexander Visekruna, Ulrich Steinhoff, Markus Bosmann, Bernd Schmeck, Wilhelm Bertrams, Leon N. Schulte, Nils Schmerer, Arjun Sharma, Hans-Joachim Mollenkopf, Aleksandra Lopez Krol, Daniel Staudenraus, Maik Luu, Hanna Leister
Apart from the constitutive proteasome, the immunoproteasome that comprises the three proteolytic subunits LMP2, MECL-1, and LMP7 is expressed in most immune cells. In this study, we describe opposing roles for immunoproteasomes in regulating the tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5cc6c0bfb1239e3c0ef9c613c33c00
https://doi.org/10.1158/2326-6066.c.6550153.v1
https://doi.org/10.1158/2326-6066.c.6550153.v1
Autor:
Hanna Leister, Ulrich Steinhoff, Bernd Schmeck, Maik Luu, Leon N. Schulte, Markus Bosmann, Hans-Joachim Mollenkopf, Daniel Staudenraus, Alexander Visekruna, Wilhelm Bertrams, Aleksandra Lopez Krol, Nils Schmerer, Arjun Sharma
Publikováno v:
Cancer Immunol Res
Apart from the constitutive proteasome, the immunoproteasome that comprises the three proteolytic subunits LMP2, MECL-1, and LMP7 is expressed in most immune cells. In this study, we describe opposing roles for immunoproteasomes in regulating the tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4210682c4818fcf8d8123ea06045670
https://doi.org/10.1158/2326-6066.cir-20-0492
https://doi.org/10.1158/2326-6066.cir-20-0492
Autor:
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Bärbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jäck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
The processes leading from disturbed B cell development to adult B cell progenitor acute lymphoblastic leukemia (BCP-ALL) are poorly understood. Here, we describe Irf4−/− mice as prone to developing BCP-ALL with age. Irf4−/− preB-I cells exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::019b2ff723d80862b81ffa903579885c
https://doi.org/10.1101/2022.02.16.480573
https://doi.org/10.1101/2022.02.16.480573
Autor:
Addi J. Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter, Dennis Das Gupta, Heike Hirseland, Daniel Staudenraus, Bärbel Camara, Kirsten Volland, Véronique Hefter, Siddhesh Sapre, Verena Krähling, Helena Müller-Kräuter, Henrik E. Mei, Christian Keller, Michael Lohoff
A third mRNA-based “booster” vaccination is the favored strategy to maintain protection against SARS-CoV-2 infection. Yet, significant waning of specific immunity within six months after 2nd vaccination, along with higher incidence of breakthroug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8160cd519cec4fc425887a79c9d7b0
https://doi.org/10.1101/2022.02.10.22270733
https://doi.org/10.1101/2022.02.10.22270733
Autor:
Daniel Staudenraus, Siddhesh Sapre, Iiris Virta, Heike Hirseland, Dennis DasGupta, Axel Schulz, Addi Romero Olmedo, Carina Münch, Svenja Hochstäter, Christian Keller, Bärbel Camara, Michael Lohoff, Henrik E. Mei, Véronique Hefter
Herein, we compared SARS-CoV-2-specific antibody and T-cell responses to two doses of BNT162b2 mRNA in 51 vaccinees > 80 years old and 46 (20–53 years old) controls. The responses of the elderly were much lower and 10% non-responders were identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea26beed0e6f28a9e4efcc7dca41e0b5
https://doi.org/10.21203/rs.3.rs-900790/v1
https://doi.org/10.21203/rs.3.rs-900790/v1
Autor:
Addi J. Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter, Dennis Das Gupta, Iiris Virta, Heike Hirseland, Daniel Staudenraus, Bärbel Camara, Carina Münch, Véronique Hefter, Siddhesh Sapre, Verena Krähling, Helena Müller-Kräuter, Marek Widera, Henrik E. Mei, Christian Keller, Michael Lohoff
Publikováno v:
Nature microbiology
Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (80 years old, n = 51) and a younger control group (20-53 years old, n = 46) after receiving two doses of BNT162b2. We found that responses in older adults were g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6dd2fe20b4b1c21e569ad4273ea983
https://pubmed.ncbi.nlm.nih.gov/35013593
https://pubmed.ncbi.nlm.nih.gov/35013593
Autor:
Addi J, Romero-Olmedo, Axel Ronald, Schulz, Svenja, Hochstätter, Dennis Das, Gupta, Heike, Hirseland, Daniel, Staudenraus, Bärbel, Camara, Kirsten, Volland, Véronique, Hefter, Siddhesh, Sapre, Verena, Krähling, Helena, Müller-Kräuter, Ho-Ryun, Chung, Henrik E, Mei, Christian, Keller, Michael, Lohoff
Publikováno v:
The Lancet Infectious Diseases. 22:588-589
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d316390f474dc0ee0ffdd438bacdd73
https://doi.org/10.1016/s1473-3099(22)00219-5
https://doi.org/10.1016/s1473-3099(22)00219-5