Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Daniel Sommermeyer"'
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Akademický článek
Development of a CD8 co-receptor independent T-cell receptor specific for tumor-associated antigen MAGE-A4 for next generation T-cell-based immunotherapy
Autor: Daniel Sommermeyer, Christian Ellinger, Giulia Longinotti, Dolores J Schendel, Michael S Magee, Kathrin Davari, Tristan Holland, Laura Prassmayer, Iulia Diaconu, Kenneth P Ganley, Lisa J Pechilis, Prashant R Nambiar
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background The cancer-testis antigen MAGE-A4 is an attractive target for T-cell-based immunotherapy, especially for indications with unmet clinical need like non-small cell lung or triple-negative breast cancer.Methods An unbiased CD137-based sorting
Externí odkaz: https://doaj.org/article/6790f2555dec4bc39ad9b227b670bd0f
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Supplementary Figure 3 from The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
Autor: Stanley R. Riddell, Michael C. Jensen, Christoph Rader, Lingfeng Liu, Anne Silva-Benedict, Paula L. Kosasih, Daniel Sommermeyer, Michael Hudecek
10 million (A) CD8+ TCM-derived CD19-CAR-T-cells, (B) CD19-CAR-T-cells derived from an unselected T-cell population, or (C) CD8+ TCM-derived ROR1-CAR-T-cells were injected into tumor-free NSG mice. After 24 hours, bone marrow, spleens, and peripheral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae10c6e8a10973bae238bca692270f8
https://doi.org/10.1158/2326-6066.22537916
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Supplementary Figure 2 from The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
Autor: Stanley R. Riddell, Michael C. Jensen, Christoph Rader, Lingfeng Liu, Anne Silva-Benedict, Paula L. Kosasih, Daniel Sommermeyer, Michael Hudecek
(A) Cytolytic activity of CD8+ TCM-derived T-cells expressing long/CD28, long/4-1BB, and long/CD28_4-1BB CD19-CARs against K562/CD19, K562, and Raji cells. (B) Cytokine production by CAR-T-cells after co-culturing with Raji cells. Supernatants were o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c94a9aaaa94797ba021685d275ae158
https://doi.org/10.1158/2326-6066.22537922.v1
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Data from Safety of Targeting ROR1 in Primates with Chimeric Antigen Receptor–Modified T Cells
Autor: Stanley R. Riddell, Christoph Rader, Paula L. Kosasih, Paulina J. Paszkiewicz, Ashwini Balakrishnan, Michael Berger, Michael Hudecek, Daniel Sommermeyer, Carolina Berger
Genetic engineering of T cells for adoptive transfer by introducing a tumor-targeting chimeric antigen receptor (CAR) is a new approach to cancer immunotherapy. A challenge for the field is to define cell surface molecules that are both preferentiall
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaf7d3721068d2fec44afb4780d2f1d3
https://doi.org/10.1158/2326-6066.c.6548518.v1
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Data from The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
Autor: Stanley R. Riddell, Michael C. Jensen, Christoph Rader, Lingfeng Liu, Anne Silva-Benedict, Paula L. Kosasih, Daniel Sommermeyer, Michael Hudecek
The use of synthetic chimeric antigen receptors (CAR) to redirect T cells to recognize tumor provides a powerful new approach to cancer immunotherapy; however, the attributes of CARs that ensure optimal in vivo tumor recognition remain to be defined.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0180856ac7c41ad413d3a4d3ad4e801c
https://doi.org/10.1158/2326-6066.c.6548606.v1
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