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pro vyhledávání: '"Daniel Siddle"'
Autor:
Rawal Jaiessh, Amy Randall, Tram T. Tran, Fiona M. Adam, Daniel Siddle, Iain Gardner, Tanya Parkinson, Manos Perros, David R. Fenwick, Christopher Pickford, Juin Fok-Seang, Charles E. Mowbray, David Howard Williams, Donald Stuart Middleton, Hannah Vuong, Peter T. Stephenson, Michelle Y. Platts, Duncan Hay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5246-5249
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a4d25958155d25e9e2f74217f4f79
https://doi.org/10.1016/j.bmcl.2009.06.080
https://doi.org/10.1016/j.bmcl.2009.06.080
