Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Daniel Severance"'
Autor:
Robbin Brodbeck, Carolyn Baltazar, Jianying Yu, Bertrand L. Chenard, Kevin P. M. Currie, Lu Yan Zhang, Hutchison Alan J, James E. Krause, Amy E. Peck, Daniel Severance, Stephen M. Waters, George D. Maynard, Jeremy Steflik
Publikováno v:
The Journal of biological chemistry. 280(49)
Anaphylatoxin C5a is a potent inflammatory mediator associated with pathogenesis and progression of several inflammation-associated disorders. Small molecule C5a receptor (C5aR) antagonist development is hampered by species-specific receptor biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadf7f629b333e6a5a75663de4b0b346
https://pubmed.ncbi.nlm.nih.gov/16230349
https://pubmed.ncbi.nlm.nih.gov/16230349
Autor:
Robin D, Clark, Alam, Jahangir, Daniel, Severance, Rick, Salazar, Thomas, Chang, David, Chang, Mary Frances, Jett, Steven, Smith, Keith, Bley
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(4)
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36bc0fd21528b6fa08f00bbc91d93aca
https://pubmed.ncbi.nlm.nih.gov/15013022
https://pubmed.ncbi.nlm.nih.gov/15013022
Autor:
Glenn E, Croston, Roger, Olsson, Erika A, Currier, Ethan S, Burstein, David, Weiner, Norman, Nash, Daniel, Severance, Stig G, Allenmark, Linda, Thunberg, Jian-Nong, Ma, Nina, Mohell, Brian, O'Dowd, Mark R, Brann, Uli, Hacksell
Publikováno v:
Journal of medicinal chemistry. 45(23)
A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II receptor. Racemic 1 had an EC50 of 300 nM at the human UII receptor and wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::223c5958634a3fb8989fb94589f70754
https://pubmed.ncbi.nlm.nih.gov/12408704
https://pubmed.ncbi.nlm.nih.gov/12408704