Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Daniel Segal"'
Safety and Tolerability, Dose-Escalating, Double-Blind Trial of Oral Mannitol in Parkinson's Disease
Autor:
Eduard Linetsky, Suaad Abd Elhadi, Max Bauer, Akiva Gallant, Montaser Namnah, Sagit Weiss, Daniel Segal, Ronit Sharon, David Arkadir
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
Mannitol, a natural alcoholic-sugar, was recently suggested as a potential disease-modifying agent in Parkinson's disease. In animal models of the disease, mannitol interferes with the formation of α-synuclein fibrils, inhibits the formation of α-s
Externí odkaz:
https://doaj.org/article/ae22e1e7083c4645a75cb1e67a979ddb
Autor:
Topaz Kreiser, Dor Zaguri, Shreya Sachdeva, Rachel Zamostiano, Josef Mograbi, Daniel Segal, Eran Bacharach, Ehud Gazit
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 377 (2022)
Controlling the infectivity of respiratory RNA viruses is critical, especially during the current SARS-CoV-2 pandemic. There is an unmet need for therapeutic agents that can reduce viral replication, preferably independent of the accumulation of vira
Externí odkaz:
https://doaj.org/article/a2c06a02eed446dabdc79352f2b54015
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 11, Pp 2215-2216 (2021)
Externí odkaz:
https://doaj.org/article/c8acd4efbee849ebbd4b5247c493092d
Autor:
Sivan Peled, Dorin Sade, Yaron Bram, Ziv Porat, Topaz Kreiser, Michael Mimouni, Alexandra Lichtenstein, Daniel Segal, Ehud Gazit
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steri
Externí odkaz:
https://doaj.org/article/d049f33829294b88ae864baa009409c9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
A current challenge faced by researchers is the lack of disease-modifying therapeutics for amyloid formation that is associated with several human diseases. Although the monomeric proteins or peptides involved in various amyloidogenic diseases do not
Externí odkaz:
https://doaj.org/article/2f4144b318db4b478a875038e9128a84
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
The aggregation of the amyloidogenic protein α-synuclein (α-Syn) into toxic oligomers and mature fibrils is the major pathological hallmark of Parkinson's disease (PD). Small molecules that inhibit α-Syn aggregation thus may be useful therapeutics
Externí odkaz:
https://doaj.org/article/3ffafac4eb414275b575c4fff0f4179f
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174495 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0169639.].
Externí odkaz:
https://doaj.org/article/0a2b7551b7374f359921087d5439a14a
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169639 (2017)
Endocytosis is a multi-step process involving a large number of proteins, both general factors, such as clathrin and adaptor protein complexes, and unique proteins, which modulate specialized endocytic processes, like the EHD proteins. EHDs are a fam
Externí odkaz:
https://doaj.org/article/c95b1b6480774ffca11b9d751087153f
Autor:
Guru KrishnaKumar Viswanathan, Satabdee Mohapatra, Ashim Paul, Elad Arad, Raz Jelinek, Ehud Gazit, Daniel Segal
Publikováno v:
Molecules, Vol 23, Iss 12, p 3279 (2018)
PAP248⁻286, a 39 amino acid peptide fragment, derived from the prostatic acid phosphatase secreted in human semen, forms amyloid fibrils and facilitates the attachment of retroviruses to host cells that results in the enhancement of viral infection
Externí odkaz:
https://doaj.org/article/8e786a2bcf174a50839dd720eaceeb04
Autor:
Efrat Oron, Tamir Tuller, Ling Li, Nina Rozovsky, Daniel Yekutieli, Sigal Rencus‐Lazar, Daniel Segal, Benny Chor, Bruce A Edgar, Daniel A Chamovitz
Publikováno v:
Molecular Systems Biology, Vol 3, Iss 1, Pp 1-13 (2007)
Abstract The COP9 signalosome (CSN), an eight‐subunit protein complex, is conserved in all higher eukaryotes. CSN intersects the ubiquitin–proteasome pathway, modulating signaling pathways controlling various aspects of development. We are using
Externí odkaz:
https://doaj.org/article/236d528cc0f34360922e49673f3c0444