Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Daniel Schnepf"'
Autor:
Valter Bergant, Daniel Schnepf, Niklas de Andrade Krätzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show
Externí odkaz:
https://doaj.org/article/41b117276b3642cfa472a74a5a5f4522
Autor:
Lena Jaki, Sebastian Weigang, Lisa Kern, Stefanie Kramme, Antoni G. Wrobel, Andrea B. Grawitz, Philipp Nawrath, Stephen R. Martin, Theo Dähne, Julius Beer, Miriam Disch, Philipp Kolb, Lisa Gutbrod, Sandra Reuter, Klaus Warnatz, Martin Schwemmle, Steven J. Gamblin, Elke Neumann-Haefelin, Daniel Schnepf, Thomas Welte, Georg Kochs, Daniela Huzly, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat infections in high-risk patients. Here, we report the adaptation of SARS-CoV-
Externí odkaz:
https://doaj.org/article/d61edc8bae2d4d3c8f29f4fd3b6b89ba
Autor:
Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson Ozer, Ndodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul-Salam Ouedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The A.27 SARS-CoV-2 lineage spread globally in 2021 but did not become dominant. Here, the authors show that A.27 shares some mutations in the spike gene that are present in variants of concern, but lacks the D614G mutation, indicating independent ev
Externí odkaz:
https://doaj.org/article/95413bc995ee4d938afb0a7f4c3cfaa7
Autor:
Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern, Julius Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, Janine Kemming, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Svenja Ulferts, Robert Grosse, Daniel Hornuss, Yakup Tanriver, Siegbert Rieg, Dirk Wagner, Daniela Huzly, Martin Schwemmle, Marcus Panning, Georg Kochs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.
Externí odkaz:
https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee
Autor:
Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Andrew J. Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Erny
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse models of Alzheimer’s disease (AD). However, the underlying mechanisms when using either germ-free (GF) housing conditions or treatments with antibioti
Externí odkaz:
https://doaj.org/article/1ef4ef2c7b524187aa55817e1899a3d0
Autor:
Liang Ye, Daniel Schnepf, Annette Ohnemus, Li Ching Ong, Hans Henrik Gad, Rune Hartmann, Nils Lycke, Peter Staeheli
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Previous work showed that interferon-λ (IFN-λ) can trigger the synthesis of thymic stromal lymphopoietin (TSLP) by specialized epithelial cells in the upper airways of mice, thereby improving the performance of intranasally administered influenza v
Externí odkaz:
https://doaj.org/article/fc7b4cc5f5364875ae5f7ffd6c23c3c0
Autor:
Daniel Schnepf, Pedro Hernandez, Tanel Mahlakõiv, Stefania Crotta, Meagan E Sullender, Stefan T Peterson, Annette Ohnemus, Camille Michiels, Ian Gentle, Laure Dumoutier, Celso A Reis, Andreas Diefenbach, Andreas Wack, Megan T Baldridge, Peter Staeheli
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0247738 (2021)
The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have indicated
Externí odkaz:
https://doaj.org/article/d68b02450db24632b3ba2774fe30dfac
Autor:
Anna Gebhardt, Valter Bergant, Daniel Schnepf, Markus Moser, Arno Meiler, Dieudonnée Togbe, Claire Mackowiak, Line S Reinert, Søren R Paludan, Bernhard Ryffel, Alexey Stukalov, Peter Staeheli, Andreas Pichlmair
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008155 (2019)
Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression of antiviral genes that are essential to combat the pathogen. Transcribed mRNAs
Externí odkaz:
https://doaj.org/article/2f2f0378c45148fa99debb5c174e921a
Autor:
Konrad C. Bradley, Katja Finsterbusch, Daniel Schnepf, Stefania Crotta, Miriam Llorian, Sophia Davidson, Serge Y. Fuchs, Peter Staeheli, Andreas Wack
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 245-256.e4 (2019)
Summary: Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. Using models of physiological and d
Externí odkaz:
https://doaj.org/article/b38812bc603440c1ac47e05b4631b8c3
Autor:
Jonas Klinkhammer, Daniel Schnepf, Liang Ye, Marilena Schwaderlapp, Hans Henrik Gad, Rune Hartmann, Dominique Garcin, Tanel Mahlakõiv, Peter Staeheli
Publikováno v:
eLife, Vol 7 (2018)
Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, m
Externí odkaz:
https://doaj.org/article/582c927dc0c04f1d916a7f6746b4ac4d