Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Daniel Schirlin"'
Publikováno v:
Bulletin de l'Académie Nationale de Médecine. 191:727-737
New lead-identification methodologies such as high-throughput screening and combinatorial chemistry have been integrated into pharmaceutical research over the past 5-10 years. More rational use in the selection of potential preclinical candidates for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05edd8d92b77329036158e7bf662e15e
https://doi.org/10.1016/s0001-4079(19)33006-7
https://doi.org/10.1016/s0001-4079(19)33006-7
Autor:
Philip S. Mayer, František Tureček, Hak-No Lee, Adi A. Scheidemann, Terry N. Olney, Frank Schumacher, Petr Štrop, Martin Smrčina, Marcel Pátek, Daniel Schirlin
Publikováno v:
Analytical Chemistry. 77:4378-4384
A specially designed mass spectrometer which allows for preparative separation of mixtures is described. This mass spectrometer allows for large ion currents, on the order of nanoamperes, to be produced by electrospray and transmitted into a high vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c4feb977ba037ce1f12c19d88ccd9d
https://doi.org/10.1021/ac050444j
https://doi.org/10.1021/ac050444j
Autor:
Daniel Schirlin, Debra L. Taylor, C. G. Bridges, P. S. Ahmed, J.-M. Hornsperger, Celine Tarnus, A. S. Tyms, V. Van Dorsselaer, T M Brennan
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:205-214
MDL 74,695, a novel dipeptide-like compound containing the ‘difluorostatone type’ transition state mimic and a potent inhibitor of the human immunodeficiency virus (HIV) proteinase, was investigated for anti-HIV activity in vitro. The compound sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f943e976d09e28100cd46fd398973d7
https://doi.org/10.1177/095632029700800304
https://doi.org/10.1177/095632029700800304
Publikováno v:
Bioorganic Chemistry. 24:178-193
The design, synthesis, and biologic evaluation of potential silicon-containing inhibitors of diamine oxidases (siladiaminopropane 1 , silaputrescine 2 , and sila analogs of cadaverine 3, 4, and 5 ) are described. All compounds have been prepared inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6d48fcf54b54a9470885f51282f5a2
https://doi.org/10.1006/bioo.1996.0016
https://doi.org/10.1006/bioo.1996.0016
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2363-2366
Several organosilicon amines were synthesized as potential mechanism-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO) prepared from rat aorta. 2-[Dimethyl(2-phenylethyl)silyl]-methanamine, hydrochloride produced potent time-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::027cc164d4982c1e80c877d5b544b796
https://doi.org/10.1016/0960-894x(95)00410-u
https://doi.org/10.1016/0960-894x(95)00410-u
Autor:
Daniel Schirlin, Pierrette Marchal, Charles Danzin, Monique Zreika, Petty Margaret A, Jean-Noel Collard
Publikováno v:
Biochemical Society Transactions. 22:768-773
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2e81c908a81a2b17dc5d3f3efbdb40
https://doi.org/10.1042/bst0220768
https://doi.org/10.1042/bst0220768
Autor:
Daniel Schirlin, Jean-Noel Collard, J Dow, Jean-Georges Heydt, Sandrine Funes, Ezio Giacobini, Jean-Marie Hornsperger
Publikováno v:
Biochemical Society Transactions. 22:758-763
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf19edd48c57c83e0c83ca7011b2413
https://doi.org/10.1042/bst0220758
https://doi.org/10.1042/bst0220758
Autor:
T M Brennan, Celine Tarnus, D. Janowick, A. S. Tyms, S. Baltzer, F. Weber, V. Van Dorsselaer, D.L. Taylor, J.M. Remy, Daniel Schirlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1213-1218
Replacement of the benzylamine carboxy terminus with a (R)-valinol ether carboxy terminus confers high inhibitory activity to derivatives of the difluorostatone and even difluorostatine types against HIV-1 protease. In HIV infected cells, the difluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e290279510467f5a187fafb7ecea9de2
https://doi.org/10.1016/s0960-894x(01)80332-2
https://doi.org/10.1016/s0960-894x(01)80332-2
Autor:
J.M. Altenburger, V. Van Dorsselaer, Daniel Schirlin, S. Baltzer, C. Weill, Gary A. Flynn, J.M. Remy, Bernhard Neises, F. Weber, Celine Tarnus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:253-258
Structure-activity relationship and concept evaluation studies have yielded short and unexpectedly potent inhibitors of HIV-1 protease of the difluorostatione type.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0b3ba199046c732617fea162da4bc4
https://doi.org/10.1016/s0960-894x(01)80887-8
https://doi.org/10.1016/s0960-894x(01)80887-8
Autor:
Jean-Bernard Ducep, Joseph Wagner, Daniel Schirlin, J. Fischer, J. M. Hornsperger, A. Mitschler, Raymond Weiss, Jean-Georges Heydt, Philippe Bey, Michel Jung, S. Baltzer, Charles Danzin, A. De Cian, F. Piriou
Publikováno v:
ChemInform. 23
The synthesis of α-(chlorofluoromethyl)-ornithine 7, -metatyrosine 8 and -glutamic acid 14 is described. Separation of diastereoisomers and relative configuration assignment by X-ray analysis are reported. Assignment of absolute configuration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9b50063110e01570c6a01ef3b5896d9
https://doi.org/10.1002/chin.199233262
https://doi.org/10.1002/chin.199233262