Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Daniel Sasca"'
Autor:
Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna L. Stiller, Stephan R. Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei Chen, Thomas Kindler, Konstanze Döhner, Francis Burrows, Matthias Theobald, Daniel Sasca, Michael W.M. Kühn
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/90cd884f6971424f8a76fbebefe0d819
Autor:
Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam
PDF file - 190K, JAK2-inhibitor trial (proliferation assay, colony assay)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e05f5e5a0cc4e507adf81e918dec21
https://doi.org/10.1158/0008-5472.22394615.v1
https://doi.org/10.1158/0008-5472.22394615.v1
Autor:
Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam
PDF file - 626K, Leukemia phenotype (FACS, immunohistochemistry)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1d304c34009c0d5c809aa1a6c47f5a
https://doi.org/10.1158/0008-5472.22394621
https://doi.org/10.1158/0008-5472.22394621
Autor:
Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam
PDF file - 339K, LSC sorting strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4934a1c32da11e78c755bbb27109a4
https://doi.org/10.1158/0008-5472.22394618.v1
https://doi.org/10.1158/0008-5472.22394618.v1
Autor:
Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132906b3dffc6b6f315cc292e6ea52ff
https://doi.org/10.1158/0008-5472.22394612.v1
https://doi.org/10.1158/0008-5472.22394612.v1
Autor:
Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam
PDF file - 58K, Colony assay with and without cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04509dc45752732e87ffa5d0fdf5d592
https://doi.org/10.1158/0008-5472.22394624
https://doi.org/10.1158/0008-5472.22394624
Autor:
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly
HOXA9 is commonly upregulated in acute myeloid leukemia (AML), in which it confers a poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3adbe43d1d79de2094f6b253d19fc9
Autor:
Oliver M. Dovey, Pedro Madrigal, Paolo Gallipoli, George S. Vassiliou, Haiyang Yun, Cameron S. Osborne, Shuchi Agrawal-Singh, Annalisa Mupo, Shabana Vohra, David Lara-Astiaso, Aracely Castillo-Venzor, Faisal Basheer, Sarah J. Horton, Brian J. P. Huntly, Ludovica Marando, Malgorzata Gozdecka, Eshwar Meduri, Carsten Müller-Tidow, Daniel Sasca, George Giotopoulos, Xiaonan Wang, Nisha Narayan
Publikováno v:
Nature Genetics. 53:1443-1455
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Autor:
Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Sarah J. Horton, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J.P. Huntly
HOXA9is commonly upregulated in acute myeloid leukemia (AML), where it confers poor prognosis. Characterising the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachment prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a3d3b93e16667dece75d4af728e86c
https://doi.org/10.1101/2022.10.12.511919
https://doi.org/10.1101/2022.10.12.511919
Autor:
Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Benedict Schubert, Haiyang Yun, Sarah J Horton, Shuchi Agrawal-Singh, Patricia S Haehnel, Faisal Basheer, Dave Lugo, Michael WM Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Rab K Prinjha, Brian JP Huntly, Daniel Sasca
Initial clinical trials with drugs targeting epigenetic modulators - such as bromodomain and extraterminal (BET) inhibitors - demonstrate modest results in acute myeloid leukemia (AML). The main reason for this involves an increased transcriptional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d2692ba4e1ae6a1d89938b2c1a17d9
https://doi.org/10.1101/2022.09.14.507850
https://doi.org/10.1101/2022.09.14.507850