Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel S. Ziemianowicz"'
Autor:
Daniel S. Ziemianowicz, Jan Kosinski
Publikováno v:
Current opinion in structural biology. 77
Integrative structural modeling enables structure determination of macromolecules and their complexes by integrating data from multiple sources. It has been successfully used to characterize macromolecular structures when a single structural biology
Autor:
Daniel S. Ziemianowicz, Daniel J. Saltzberg, D. Alex Crowder, Christoph U. Schräder, Andrej Sali, Troy J. Pells, Morgan Hepburn, David C. Schriemer
Publikováno v:
Molecular & Cellular Proteomics : MCP
Proteomics methodology has expanded to include protein structural analysis, primarily through cross-linking mass spectrometry (XL-MS) and hydrogen–deuterium exchange mass spectrometry (HX-MS). However, while the structural proteomics community has
Autor:
Mandy Rettel, Katherine S. H. Beckham, Grzegorz Chojnowski, Jan Kosinski, Edukondalu Mullapudi, Daniel S. Ziemianowicz, Mikhail M. Savitski, Matthias Wilmanns, Christina Ritter, Simon A. Mortensen
Publikováno v:
Science Advances
Science advances 7(26), eabg9923-(2021). doi:10.1126/sciadv.abg9923
Science advances 7(26), eabg9923-(2021). doi:10.1126/sciadv.abg9923
Science advances 7(26), eabg9923 - (2021). doi:10.1126/sciadv.abg9923
The ESX-5 type VII secretion system is a membrane-spanning protein complex key to the virulence of mycobacterial pathogens. However, the overall architecture of the fully asse
The ESX-5 type VII secretion system is a membrane-spanning protein complex key to the virulence of mycobacterial pathogens. However, the overall architecture of the fully asse
Publikováno v:
Analytical Chemistry. 91:8492-8499
Covalent labeling with mass spectrometry (CL-MS) provides a direct measure of the chemical and structural features of proteins with the potential for resolution at the amino-acid level. Unfortunately, most applications of CL-MS are limited to narrowl
Publikováno v:
Journal of Proteome Research. 18:934-946
Structure-based approaches to the delineation of immunogens for vaccine development have a throughput requirement that is difficult to meet in practice with conventional methods of structure determination. Here we present a strategy for rapid and acc
Autor:
Atefeh Rafiei, Udit Dalwadi, David C. Schriemer, Calvin K. Yip, Noah J Harris, Emily M. Martin, Kaelin D. Fleming, Meredith L. Jenkins, Daniel S. Ziemianowicz, John E. Burke
Publikováno v:
Communications Biology
The TRAnsport Protein Particle (TRAPP) complexes act as Guanine nucleotide exchange factors (GEFs) for Rab GTPases, which are master regulators of membrane trafficking in eukaryotic cells. In metazoans, there are two large multi-protein TRAPP complex
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31(2)
The functional properties of a protein are strongly influenced by its topography, or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topographical
Autor:
Chloe Sage, Matthew Brendan Munn, Kenneth W. Tupper, Deanne Taylor, Mark Leigh, Silvina C. Mema, Karen McCrae, Daniel S. Ziemianowicz, Trevor Corneil, Yuhui Xu
Publikováno v:
Canadian Journal of Public Health. 109:740-744
SETTING: Shambhala is a 5-day electronic dance music (EDM) festival held in rural British Columbia that annually hosts between 15,000 and 18,000 people on a 500-acre ranch. The AIDS Network Outreach & Support Society (ANKORS) has provided harm reduct
Publikováno v:
Analytical Chemistry. 90:3083-3090
Dynamic post-translational modifications of histones regulate transcriptional gene expression in eukaryotes. Unique combinations of modifications, almost exclusively displayed at the flexible N-terminal tails on histones, create distributions of prot
Autor:
Morgan Hepburn, Atefeh Rafiei, David C. Schriemer, Vladimir Sarpe, Troy J. Pells, Shaunak Raval, Daniel S. Ziemianowicz, D. Alex Crowder
Publikováno v:
Journal of Proteomics. 225:103844
Structural Mass Spectrometry (SMS) provides a comprehensive toolbox for the analysis of protein structure and function. It offers multiple sources of structural information that are increasingly useful for integrative structural modeling of complex p