Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Daniel S. Perrien"'
Autor:
Subhashis Pal, Daniel S. Perrien, Tetsuya Yumoto, Roberta Faccio, M. Neale Weitzmann, Roberto Pacifici
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100540- (2024)
Externí odkaz:
https://doaj.org/article/7f5a000edf124d0598b1213347b637e1
Autor:
Hamid Y. Dar, Daniel S. Perrien, Subhashis Pal, Andreea Stoica, Sasidhar Uppuganti, Jeffry S. Nyman, Rheinallt M. Jones, M. Neale Weitzmann, Roberto Pacifici
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
IL-17A (IL-17), a driver of the inflammatory phase of fracture repair, is produced locally by several cell lineages including γδ T cells and Th17 cells. However, the origin of these T cells and their relevance for fracture repair are unknown. Here,
Externí odkaz:
https://doaj.org/article/e7c326a38cc94c839b118e5319d657e2
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone
Autor:
Subhashis Pal, Daniel S. Perrien, Tetsuya Yumoto, Roberta Faccio, Andreea Stoica, Jonathan Adams, Craig M. Coopersmith, Rheinallt M. Jones, M. Neale Weitzmann, Roberto Pacifici
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the role of the microbiome in tumor gro
Externí odkaz:
https://doaj.org/article/0ac1f9b7c55d481081666201ef90533a
Autor:
Timothy E. Thayer, Christian L. Lino Cardenas, Trejeeve Martyn, Christopher J. Nicholson, Lisa Traeger, Florian Wunderer, Charles Slocum, Haakon Sigurslid, Hannah R. Shakartzi, Caitlin O’Rourke, Georgia Shelton, Mary D. Buswell, Hanna Barnes, Leif R. Neitzel, Clara D. Ledsky, Jason Pingcheng Li, Megan F. Burke, Eric Farber-Eger, Daniel S. Perrien, Ravindra Kumar, Kathleen E. Corey, Quinn S. Wells, Kenneth D. Bloch, Charles C. Hong, Donald B. Bloch, Rajeev Malhotra
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is un
Externí odkaz:
https://doaj.org/article/0b2d4d623f694b79a8b273377b95590c
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 630 (2021)
Excess inflammation and canonical BMP receptor (BMPR) signaling are coinciding hallmarks of the early stages of injury-induced endochondral heterotopic ossification (EHO), especially in the rare genetic disease fibrodysplasia ossificans progressiva (
Externí odkaz:
https://doaj.org/article/22fb13191ca24a2c8e4595b4571b5672
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 3, Pp 359-367 (2011)
SUMMARY Abnormal Notch signaling in humans results in Alagille syndrome, a pleiotropic disease characterized by a paucity of intrahepatic bile ducts (IHBDs). It is not clear how IHBD paucity develops as a consequence of atypical Notch signaling, whet
Externí odkaz:
https://doaj.org/article/816475aea4a84078a30113c77ab26a59
Autor:
Alexandra Denys, Allison Norman, Daniel S Perrien, Larry J Suva, Liz Simon, Lee S McDaniel, Tekeda Ferguson, Kim Pedersen, David Welsh, Patricia E Molina, Martin JJ Ronis
Publikováno v:
JBMR Plus. 7
Autor:
Daniel S. Perrien, Jessica L. Pierce
Publikováno v:
Current Osteoporosis Reports. 19:358-367
Fibrodysplasia ossificans progressiva (FOP) is a debilitating rare disease known for episodic endochondral heterotopic ossification (HO) caused by gain-of-function mutations in ACVR1/ALK2. However, disease severity varies among patients with identica
Publikováno v:
Biomedicines
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 630, p 630 (2021)
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 630, p 630 (2021)
Excess inflammation and canonical BMP receptor (BMPR) signaling are coinciding hallmarks of the early stages of injury-induced endochondral heterotopic ossification (EHO), especially in the rare genetic disease fibrodysplasia ossificans progressiva (
Autor:
Hiroyuki Yamaguchi, Megumi Kitami, Karin H. Uchima Koecklin, Li He, Jianbo Wang, William R. Lagor, Daniel S. Perrien, Yoshihiro Komatsu
Publikováno v:
Developmental biology. 482
Ciliogenic components, such as the family of intraflagellar transport (IFT) proteins, are recognized to play key roles in endochondral ossification, a critical process to form most bones. However, the unique functions and roles of each IFT during end