Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Daniel S. McGehee"'
Autor:
Shannon L. Wolfman, Daniel F. Gill, Fili Bogdanic, Katie Long, Ream Al-Hasani, Jordan G. McCall, Michael R. Bruchas, Daniel S. McGehee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucle
Externí odkaz:
https://doaj.org/article/e15d944c114d4cb58850d8356381d660
Autor:
Sean Austin O. Lim, Rong Xia, Yunmin Ding, Lisa Won, William J. Ray, Stephen A. Hitchcock, Daniel S. McGehee, Un Jung Kang
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 67-76 (2015)
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of l-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergi
Externí odkaz:
https://doaj.org/article/250b8769fd3246af8e7899fcd8c6a4bb
Autor:
Jeff A. Beeler, Michael J. Frank, John McDaid, Erin Alexander, Susie Turkson, Maria Sol Bernandez, Daniel S. McGehee, Xiaoxi Zhuang
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1747-1761 (2012)
Dopamine contributes to corticostriatal plasticity and motor learning. Dopamine denervation profoundly alters motor performance, as in Parkinson’s disease (PD); however, the extent to which these symptoms reflect impaired motor learning is unknown.
Externí odkaz:
https://doaj.org/article/17c4e98ec9f94f1cb57b7bd9fecc12d5
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 78-85 (2007)
In addition to the loss of spinal motor neurons, amyotrophic lateral sclerosis (ALS) is also associated with degeneration of corticospinal layer V pyramidal neurons and decreased glutamate transport in the cortex. We characterized the glutamate recep
Externí odkaz:
https://doaj.org/article/759e972538aa4ccc8a48fda7669baeec
Autor:
Jeff A. Beeler, Michael J. Frank, John McDaid, Erin Alexander, Susie Turkson, Maria Sol Bernardez Sarria, Daniel S. McGehee, Xiaoxi Zhuang
Publikováno v:
Cell Reports, Vol 8, Iss 2, p 646 (2014)
Externí odkaz:
https://doaj.org/article/f28632acb45f4287a1fb29fddcf1dc1e
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 6 (2014)
The striatum plays a central role in motor control and motor learning. Appropriate responses to environmental stimuli, including pursuit of reward or avoidance of aversive experience all require functional striatal circuits. These pathways integrate
Externí odkaz:
https://doaj.org/article/1e675807e9c2422985ba3c6f53a21027
Autor:
Anastasia Sorokina, Mark E. J. Sheffield, Daniel S. McGehee, Gregg A. Wildenberg, Alexis Monical, Jessica L. Koranda, Xiaoxi Zhuang, Chad Heer, Narayanan Kasthuri
Detailing the ways drugs of abuse physically alter dopaminergic circuits would provide new mechanisms for explaining addictive behaviors, future targets for therapeutic intervention, and insights into the nature of synaptic plasticity. We combine rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::258a34bb86c8c8f266ee270b442f56f9
https://doi.org/10.21203/rs.3.rs-136861/v1
https://doi.org/10.21203/rs.3.rs-136861/v1
Publikováno v:
SSRN Electronic Journal.
SummaryIn Parkinson’s disease (PD) patients, dopamine replacement therapy requires days to reach maximal effects, and the return of symptoms without treatment is similarly delayed. We previously postulated that these phenomena are mediated by plast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9868c9a7346b0e75627523a4956a6fc
https://doi.org/10.2139/ssrn.3956658
https://doi.org/10.2139/ssrn.3956658
Autor:
C. Heer, A. Monical, Daniel S. McGehee, Anastasia Sorokina, Mark E. J. Sheffield, Gregg A. Wildenberg, Narayanan Kasthuri, Jessica L. Koranda, Xiaoxi Zhuang
SummaryDopaminergic (DA) neurons exert profound influences on behavior including addiction. However, how DA axons communicate with target neurons and how those communications change, for example, with drug exposure, remains poorly understood. We comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5443f61e76220424b4023041f33f1403
https://doi.org/10.1101/2020.09.29.318881
https://doi.org/10.1101/2020.09.29.318881
Autor:
Daniel S. McGehee, Katie Long, Jordan G. McCall, Fili Bogdanic, Ream Al-Hasani, Daniel F. Gill, Shannon L. Wolfman, Michael R. Bruchas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Nicotine use can lead to dependence through complex processes that are regulated by both its rewarding and aversive effects. Recent studies show that aversive nicotine doses activate excitatory inputs to the interpeduncular nucleus (IPN) from the med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341b5f9c3c6c1ba46d8c5e234424e88a
http://link.springer.com/article/10.1038/s41467-018-04654-2
http://link.springer.com/article/10.1038/s41467-018-04654-2