Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel S. Hsieh"'
Autor:
Mark Lindrud, Nathaniel Kopp, David Buckley, Gregory Lane, Deniz Erdemir, Daniel S. Hsieh, Whitney Nikitczuk, Jing Tao, Adriene Malsbury, Vivek Daftary, Joshua Engstrom
Publikováno v:
Organic Process Research & Development. 23:2685-2698
Many active pharmaceutical ingredients (APIs) display poor powder properties and cannot be directly compressed into tablets with sufficient strength. The desired powder properties are often difficu...
Publikováno v:
Organic Process Research & Development. 22:608-617
The formation of hard agglomerates during drying has impacts on the product quality, particle size distribution, and downstream formulation. Hence, understanding the cause of hard agglomerates and determining a remedy for them or preventing their for
Publikováno v:
Organic Process Research & Development. 21:1509-1520
The mechanistic understanding of three key active pharmaceutical ingredient (API) drying elements: drying kinetics, physical property control, and stability control, is critical for downstream formulation development and manufacture. The objective of
Publikováno v:
Organic Process Research & Development. 21:1272-1285
The objective of this study is to recover Active Pharmaceutical Ingredients (APIs) from tablets via green engineering technology to meet material requirements for downstream formulation development. A separation train, using water as the separation m
Publikováno v:
Crystal Growth & Design. 16:12-24
A novel pure component approach using HyperDSC for the relative stability determination was reported in 2012 (Hsieh et al. Cryst. Growth Des. 2012, 12, 5481). The accuracy of this approach depends upon the accurate physical properties of the amorphou
Publikováno v:
Pharmaceutical research. 35(4)
To understand hydrolysis and alcoholysis of polyvinylpyrrolidone-co-vinylacetate (PVPVA) during formulation and storage, elucidate the reaction mechanism, establish an intrinsic kinetic model, and apply this model coupled with GastroPlus™ modeling
Autor:
Jun Li, Qi Gao, Deniz Erdemir, Chiajen Lai, Ming Huang, Alicia Ng, Daniel G.M. Roberts, Jun Huang, Daniel S. Hsieh, David K. Leahy
Publikováno v:
Crystal Growth & Design. 12:5481-5490
The determination of the relative stability of multipolymorph compounds is very important to chemical processes and product development. Two thermodynamic methods are used in this study: a eutectic method and a pure component method. The eutectic met
Autor:
Daniel G.M. Roberts, Mark Lindrud, Sarah J. Nicholson, Richard L. Schild, Daniel S. Hsieh, Hongfei Yue, John F. Gamble
Publikováno v:
Pharmaceutical research. 32(5)
To understand the mechanisms of secondary drying of spray-dried dispersion (SDD) drug product and establish a model to describe the fate of organic solvents in such a product. The experimental approach includes characterization of the SDD particles,
Autor:
Beth A. Sarsfield, Shih-Ying Chang, Daniel S. Hsieh, Lynn M. DiMemmo, Martha Davidovich, San Kiang
Publikováno v:
Journal of pharmaceutical sciences. 99(9)
The control of crystalline and amorphous phases is important during the development of a new drug candidate. Our approach begins with an understanding of the thermodynamics of these two phases. We have developed a quantitative yet practical work flow
Publikováno v:
ChemInform. 41