Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Daniel S. Fletcher"'
Autor:
Daniel S. Fletcher, Renee M. Chabin, Stephan K. Grant, Barbara G. Green, John L. Humes, D. Euan MacIntyre, Silvi Luell, Ravindra N. Guthikonda, Richard G. Ball, Richard A. Mumford, Malcolm MacCoss, Nancy N. Tsou, Stephen G. Pacholok, Shrenik K. Shah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1997-2001
Syntheses and nitric oxide synthase inhibitory activity of cyclic amidines containing 5,6- 6,6- and 7,6-fused systems are described. X-ray structure determination facilitated the assignment of the stereochemistry of the most active compounds perhydro
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 277:G801-G809
Type 1 plasminogen activator inhibitor (PAI-1), a major physiological inhibitor of plasminogen activation, is an important component of the hepatic acute phase response. We studied the acute phase regulation of murine hepatic PAI-1 in response to sys
Autor:
Myrna E. Trumbauer, Daniel S. Fletcher, Karen Sokol, Qiao-wen Xie, Gary J Hom, Carl Nathan, Karla Stevens, John D. MacMicking, Nicole A. Chartrain, John S. Mudget, Nancy I. Hutchinson, Howard Y. Chen
Publikováno v:
Cell. 81(4):641-650
Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that !NOS defends the host against infectious agents and tumor cells at the risk of contributing to tissue damage and shock. iNOS -I- mice failed to restrain the
Autor:
Renee M. Chabin, Daniel S. Fletcher, William A. Hanlon, Barbara G. Green, W. B. Knight, Thomas J. Lanza, Stephen G. Pacholok, John L. Humes, Malcolm MacCoss, Philippe L. Durette, Richard A. Mumford
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:271-274
Analogs of the monocyclic β-lactam human leukocyte elastase (HLE) inhibitor L-680,833 in which the carboxyl group is replaced by phosphorous acid moieties were synthesized and found to be potent inhibitors of the enzyme ( k inact / K i in the range
Autor:
Daniel S. Fletcher, M.Ellen Dahlgren, Bonnie M. Ash, Philip Davies, Conrad P. Dorn, Donald G. Osinga, H. Weston, Shrenik K. Shah, R. J. Bonney, Pau.E. Finke, Pam S. Dellea, Jeffrey J. Hale, William K. Hagmann, Karen A. Brause, Kevan R. Thompson, Karen M. Hand, Alan L. Maycock, James B. Doherty, Laura A. O'Grady
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:545-550
Simple 3-alkyl-4-azetidinones have been previously reported as potent inhibitors of human leukocyte elastase (HLE). Further modification of these simple monocyclic β-lactams has led to development of substituted 4-azetidinones that both inhibit HLE
Autor:
Donald G. Osinga, Paul E. Finke, William K. Hagmann, Philip Davies, Daniel S. Fletcher, Pam S. Dellea, Karen M. Hand, Richard A. Mumford, James B. Doherty, R. J. Bonney, Bonnie M. Ashe
Publikováno v:
American Review of Respiratory Disease. 141:672-677
A pharmacokinetic model is described for testing of polymorphonuclear leukocyte (PMN) elastase inhibitors administered by intratracheal or aerosol dosing of hamsters. Acute lung injury, measured as hemorrhage occurring within hours after intratrachea
Autor:
Daniel S. Fletcher, Christopher A. Salvatore, Beverly H. Koller, Stephen L. Tilley, Marlene A. Jacobson, Anne M. Latour
Publikováno v:
The Journal of biological chemistry. 275(6)
The A(3) adenosine receptor (A3AR) is one of four receptor subtypes for adenosine and is expressed in a broad spectrum of tissues. In order to study the function of A3AR, a mouse line carrying a mutant A(3) allele was generated. Mice homozygous for t
Autor:
Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne, David A. Claremon, Brian E. Libby, Kevin T. Nguyen, Steven M. Pitzenberger, Harold G. Selnick, Garry R. Smith, Andrew Tebben, Joseph P. Vacca, Sandor L. Varga, Lily Agarwal, Kim Dancheck, Amy J. Forsyth, Daniel S. Fletcher, Betsy Frantz, William A. Hanlon, Coral F. Harper, Scott J. Hofsess, Matthew Kostura, Jiunn Lin, Sylvie Luell, Edward A. O'Neill, Chad J. Orevillo, Margaret Pang, Janey Parsons, Anna Rolando, Yousif Sahly, Denise M. Visco, Stephen J. O'Keefe
Publikováno v:
Journal of medicinal chemistry. 42(12)
Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays of tumor necrosis factor-alpha (TNF-alpha) release and an animal model of rheumatoid arthr
Autor:
Malcolm MacCoss, Stephen E. de Laszlo, Nathan B. Mantlo, Bing Li, Candice Hacker, Janey N. Parsons, W.Rick Widmer, Matthew J. Kostura, Anna M. Rolando, Betsy Frantz, Gist Croft, Chad Orevillo, Yousif S Sahly, Amy Forsyth, William A. Hanlon, Linda Chang, Jayne Chin, Stephen J. O'Keefe, Edward A. O'Neill, Denise M. Visco, Kelley Sidler, Daniel S. Fletcher, Coral Harper, Lily Agarwal, Margaret Pang, Sylvie Luell
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(19)
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrole (L-167307) reduces secondary paw s
Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice
Autor:
Alan Shaw, Michael J. Tocci, Hugh Rosen, Howard Y. Chen, Daniel S. Fletcher, Carole A. Corn, Kathryn J. Hofmann, Myrna E. Trumbauer, Matthew J. Kluger, Karla Stevens, Hui Zheng, Minghao Jiang, Christina Grabiec, Matthew J. Kostura, Robert J. North, Lex H.T. Van der Ploeg, Darlusz Soszynski, Wieslaw Kozak
Publikováno v:
Immunity. 3(1)
We used gene targeting in embryonic stem cells to introduce an IL-1 beta null allele in mice. The IL-1 beta-deficient mice develop normally and are apparently healthy and fertile. The IL-1 beta null mice responded normally in models of contact and de