Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation

Autor: Jean-François Darrigrand, Mariana Valente, Glenda Comai, Pauline Martinez, Maxime Petit, Ryuichi Nishinakamura, Daniel S Osorio, Gilles Renault, Carmen Marchiol, Vanessa Ribes, Bruno Cadot

Publikováno v: eLife, Vol 9 (2020)

The establishment of separated pulmonary and systemic circulation in vertebrates, via cardiac outflow tract (OFT) septation, is a sensitive developmental process accounting for 10% of all congenital anomalies. Neural Crest Cells (NCC) colonising the

Externí odkaz: https://doaj.org/article/a7906c9a3e624af9a92d1a9cf93e2530

Plastin and Β-Heavy-Spectrin Cooperate to Stabilize the Actomyosin Cortex During Cytokinesis

Autor: Daniel S. Osorio, Vanessa Ferreira, Fung-Yi Chan, Ana Filipa Sobral, Daniel José Barbosa, Dhanya K. Cheerambathur, Ana Carvalho, Reto Gassmann

Publikováno v: SSRN Electronic Journal.

Cytokinesis, the process that partitions the mother cell into two daughter cells, requires the assembly and constriction of an equatorial actomyosin network. Different types of non-motor F-actin crosslinkers localize to the network, but their functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5bde08a785b9baed2ebf2331d756db5
https://doi.org/10.2139/ssrn.3779552

PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning

Autor: Ana Carvalho, Eric J. Lambie, Hai Wei, Daniel S. Osorio, Barbara Conradt

Publikováno v: PLoS Genetics, Vol 16, Iss 9, p e1008912 (2020)
PLoS Genetics

The mechanism(s) through which mammalian kinase MELK promotes tumorigenesis is not understood. We find that theC. elegansorthologue of MELK, PIG-1, promotes apoptosis by partitioning an anti-apoptotic factor. TheC. elegansNSM neuroblast divides to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e89eb8b227c8d8bb6fd9f36c74a4f95
https://doi.org/10.1101/2020.06.04.133983

Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis

Autor: Michael J. Norman, Daniel S. Osorio, Vanessa Ferreira, Ana Filipa Sobral, Reto Gassmann, Dhanya K. Cheerambathur, Daniel José Barbosa, Julio M. Belmonte, Ana Beatriz Dias, Fung-Yi Chan, Ana Carvalho

Publikováno v: Current Biology
Sobral, A F, Chan, F Y, Norman, M J, Osório, D S, Dias, A B, Ferreira, V, Barbosa, D J, Cheerambathur, D, Gassmann, R, Belmonte, J M & Carvalho, A X 2021, ' Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis ', Current Biology, vol. 31, no. 24, pp. 5415-5428.e10 . https://doi.org/10.1016/j.cub.2021.09.055

Summary Cytokinesis, the process that partitions the mother cell into two daughter cells, requires the assembly and constriction of an equatorial actomyosin network. Different types of non-motor F-actin crosslinkers localize to the network, but their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef5afefa62a9b9e495cf9b759f62528
https://doi.org/10.1016/j.cub.2021.09.055

Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans

Autor: Joana Leite, Ana Filipa Sobral, Fung-Yi Chan, Ana M. G. Silva, Joana Saramago, Ana Carvalho, Daniel S. Osorio, Reto Gassmann

Publikováno v: Development (Cambridge, England)
Development

Cytokinesis in animal cells requires the assembly and constriction of a contractile actomyosin ring. Non-muscle myosin II is essential for cytokinesis, but the role of its motor activity remains unclear. Here, we examine cytokinesis in C. elegans emb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbf9c3acde9b17a55150d30d28d5f53
https://doi.org/10.1242/dev.179150