Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daniel S, Widmer"'
Autor:
Ismael A. Vergara, Christopher P. Mintoff, Shahneen Sandhu, Lachlan McIntosh, Richard J. Young, Stephen Q. Wong, Andrew Colebatch, Daniel L. Cameron, Julia Lai Kwon, Rory Wolfe, Angela Peng, Jason Ellul, Xuelin Dou, Clare Fedele, Samantha Boyle, Gisela Mir Arnau, Jeanette Raleigh, Athena Hatzimihalis, Pacman Szeto, Jennifer Mooi, Daniel S. Widmer, Phil F. Cheng, Valerie Amann, Reinhard Dummer, Nicholas Hayward, James Wilmott, Richard A. Scolyer, Raymond J. Cho, David Bowtell, Heather Thorne, Kathryn Alsop, Stephen Cordner, Noel Woodford, Jodie Leditschke, Patricia O’Brien, Sarah-Jane Dawson, Grant A. McArthur, Graham J. Mann, Mitchell P. Levesque, Anthony T. Papenfuss, Mark Shackleton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubl
Externí odkaz:
https://doaj.org/article/4c17fb9d0e02463397deea2b50e28d35
Autor:
Andrew J. Colebatch, Anthony T. Papenfuss, Clare G Fedele, Nicholas K. Hayward, Pacman Szeto, Jodie Leditschke, Richard A. Scolyer, Jennifer Mooi, Raymond J. Cho, Athena Hatzimihalis, Daniel L Cameron, Heather Thorne, Jason Ellul, Mitchell P. Levesque, Stephen Cordner, Grant A. McArthur, Noel Woodford, Julia Lai Kwon, Phil F. Cheng, Sarah-Jane Dawson, Reinhard Dummer, Rory Wolfe, Kathryn Alsop, Mark Shackleton, Angela Peng, Daniel S. Widmer, Gisela Mir Arnau, Jeanette Raleigh, Richard J. Young, Valerie C Amann, Ismael A. Vergara, Lachlan McIntosh, Shahneen Sandhu, James S. Wilmott, Xuelin Dou, Stephen Q. Wong, Graham J. Mann, Patricia C. M. O’Brien, Christopher P. Mintoff, David D.L. Bowtell, Samantha E. Boyle
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of genetic changes that characterise lethal metastatic disease is poorly understood. Here, we analyze the
Autor:
Phil F. Cheng, Daniel S. Widmer, Reinhard Dummer, Mitchell P. Levesque, Sima Rozati, Kazuyasu Fujii
Publikováno v:
Clinical Cancer Research. 22:2020-2031
Purpose: Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of malignancies that despite available therapies commonly relapse. The emergence of combination epigenetic therapies in other hematologic malignancies have made investigation of suc
Autor:
Martin Meuli, Ossia M. Eichhoff, Ernst Reichmann, Sophie Böttcher-Haberzeth, Erik Braziulis, Daniel S. Widmer, Luca Pontiggia, Clemens Schiestl, Claudia Meuli-Simmen, Thomas Biedermann, Bart Hendriks
Publikováno v:
Journal of Investigative Dermatology; Vol 133
Recently, Biedermann et al. (2010) have demonstrated that human eccrine sweat gland cells can develop a multilayered epidermis. The question still remains whether these cells can fulfill exclusive and very specific functional properties of epidermal
Autor:
Apurva Narechania, Ossia M. Eichhoff, Reinhard Dummer, Daniel S. Widmer, Sandra N. Freiberger, Phil F. Cheng, Mitchell P. Levesque, Marieke I.G. Raaijmakers, Rob DeSalle, Judith Wenzina, Daniela Mihic-Probst
Publikováno v:
Oncotarget
Acquired chemotherapeutic resistance of cancer cells can result from a Darwinistic evolution process in which heterogeneity plays an important role. In order to understand the impact of genetic heterogeneity on acquired resistance and second line the
Autor:
Hiroko Fujii, Yumi Nonomura, Atsushi Otsuka, Joanna Mangana, Gabriele Fenini, Christoffer Gebhardt, Takashi K. Satoh, Roman Huber, Kenji Kabashima, Lars E. French, Katrin Kerl, Daniel S. Widmer, Chisa Nakashima, Reinhard Dummer, Barbara Meier, Samuel Gehrke, Emmanuel Contassot, Mitchell P. Levesque
Publikováno v:
Scientific Reports
Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses and promotes the accumulation of macrophages in the tumour microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef63e44cf7f970c0cc253b44eb9ef60
https://www.zora.uzh.ch/id/eprint/125918/
https://www.zora.uzh.ch/id/eprint/125918/
Autor:
Ossia M. Eichhoff, Benedetta Belloni, Phil F. Cheng, Natalie C. Schlegel, Alain Mauviel, Marie C. Zipser, Reinhard Dummer, Delphine Javelaud, Keith S. Hoek, Daniel S. Widmer
Publikováno v:
Pigment Cell & Melanoma Research. 25:343-353
There is growing evidence that the metastatic spread of melanoma is driven not by a linear increase in tumorigenic aggressiveness, but rather by switching back and forth between two different phenotypes of metastatic potential. In vitro these phenoty
Autor:
Ossia M. Eichhoff, Keith S. Hoek, Mai Xu, Marie C. Zipser, Lydia Kriegl, Lionel Larue, Thomas Kirchner, Ashani T. Weeraratna, Laurence Denat, Daniel S. Widmer, Reinhard Dummer
Publikováno v:
Pigment Cell & Melanoma Research. 24:631-642
Recent observations suggest that melanoma cells drive disease progression by switching back and forth between phenotypic states of proliferation and invasion. Phenotype switching has been linked to changes in Wnt signalling, and we therefore looked f
Autor:
Reinhard Dummer, Paul D. Smith, Keith S. Hoek, Ossia M. Eichhoff, Darrin Stuart, Paolo Nuciforo, Daniel S. Widmer, Humphrey Gardner, Marie C. Zipser, Weihua Liu, Natalie C. Schlegel, Nicola L. Schoenewolf
Publikováno v:
Pigment Cell & Melanoma Research. 24:326-333
Oncogenic mutations within the MAPK pathway are frequent in melanoma, and targeting of MAPK signaling has yielded spectacular responses in a significant number of patients that last for several months before relapsing. We investigated the effects of
Autor:
Marie C, Zipser, Ossia M, Eichhoff, Daniel S, Widmer, Natalie C, Schlegel, Nicola L, Schoenewolf, Darrin, Stuart, Weihua, Liu, Humphrey, Gardner, Paul D, Smith, Paolo, Nuciforo, Reinhard, Dummer, Keith S, Hoek
Publikováno v:
Pigment cell & melanoma research
Oncogenic mutations within the MAPK pathway are frequent in melanoma, and targeting of MAPK signaling has yielded spectacular responses in a significant number of patients that last for several months before relapsing. We investigated the effects of