Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Daniel S, Reich"'
Autor:
Ingrid Berg, Pia Härvelid, Wolfgang Emanuel Zürrer, Marianna Rosso, Daniel S. Reich, Benjamin Victor Ineichen
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105434- (2024)
Summary: Background: Despite successes in multiple sclerosis (MS) drug development, the effectiveness of animal studies in predicting successful bench-to-bedside translation is uncertain. Our goal was to identify predictors of successful animal-to-hu
Externí odkaz:
https://doaj.org/article/8085a892e46248b1945d154f25975289
Autor:
Andrew A Chen, Kelly Clark, Blake E Dewey, Anna DuVal, Nicole Pellegrini, Govind Nair, Youmna Jalkh, Samar Khalil, Jon Zurawski, Peter A Calabresi, Daniel S Reich, Rohit Bakshi, Haochang Shou, Russell T Shinohara, Alzheimer’s Disease Neuroimaging Initiative, and North American Imaging in Multiple Sclerosis Cooperative
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012241 (2024)
Dimension reduction tools preserving similarity and graph structure such as t-SNE and UMAP can capture complex biological patterns in high-dimensional data. However, these tools typically are not designed to separate effects of interest from unwanted
Externí odkaz:
https://doaj.org/article/6dc81d154df04a90a16c0ae4b80ffc44
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Neurodegenerative and neuroinflammatory diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, affect millions of people globally. As aging is a major risk factor for neurodegenerative diseases, the continuous incre
Externí odkaz:
https://doaj.org/article/c674170f360d49ce8d38996883f45e79
Autor:
Emily H. Stack, Serhat V. Okar, Tianxia Wu, Mallory Stack, Yair Mina, María Gaitán, Shila Azodi, Will Frazier, Joan Ohayon, Irene C. M. Cortese, Daniel S. Reich, Govind Nair, Steven Jacobson
Publikováno v:
Pathogens, Vol 13, Iss 11, p 920 (2024)
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neurological disorder and shares many radiological and clinical features with other more prevalent myelopathies. Here, we quantified spinal cord and brain v
Externí odkaz:
https://doaj.org/article/7e5b735414304a2e98a13303a7b12a83
Autor:
Corinne Donnay, Serhat V. Okar, Charidimos Tsagkas, María I. Gaitán, Megan Poorman, Daniel S. Reich, Govind Nair
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Ultra-low field (ULF) magnetic resonance imaging (MRI) holds the potential to make MRI more accessible, given its cost-effectiveness, reduced power requirements, and portability. However, signal-to-noise ratio (SNR) drops with field strength, necessi
Externí odkaz:
https://doaj.org/article/731756bad2334064923ae2304844480e
Autor:
Jacob M. Stillman, Francisco Mendes Lopes, Jing-Ping Lin, Kevin Hu, Daniel S. Reich, Dorothy P. Schafer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Engulfment of cellular material and proteins is a key function for microglia, a resident macrophage of the central nervous system (CNS). Among the techniques used to measure microglial engulfment, confocal light microscopy has been used the
Externí odkaz:
https://doaj.org/article/808ca7f8840f426781d6f6718d971338
Autor:
Corinne Donnay, Henry Dieckhaus, Charidimos Tsagkas, María Inés Gaitán, Erin S. Beck, Andrew Mullins, Daniel S. Reich, Govind Nair
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
IntroductionAutomatic whole brain and lesion segmentation at 7T presents challenges, primarily from bias fields, susceptibility artifacts including distortions, and registration errors. Here, we sought to use deep learning algorithms (D/L) to do both
Externí odkaz:
https://doaj.org/article/3b5b15fe013f4545a3f57498e8b49799
Autor:
Elif Everest, Mohammad Ahangari, Ugur Uygunoglu, Melih Tutuncu, Alper Bulbul, Sabahattin Saip, Taskin Duman, Ugur Sezerman, Daniel S. Reich, Brien P. Riley, Aksel Siva, Eda Tahir Turanli
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Many multiple sclerosis (MS)-associated common risk variants as well as candidate low-frequency and rare variants have been identified; however, approximately half of MS heritability remains unexplained. We studied seven multiplex MS familie
Externí odkaz:
https://doaj.org/article/7acd82bda4b04a91b990b573b6ebbd1e
Autor:
Michelle L. Pleet, Joshua A. Welsh, Emily H. Stack, Sean Cook, Dove-Anna Johnson, Bryce Killingsworth, Tim Traynor, Annaliese Clauze, Randall Hughes, Maria Chiara Monaco, Nyater Ngouth, Joan Ohayon, Yoshimi Enose-Akahata, Avindra Nath, Irene Cortese, Daniel S. Reich, Jennifer C. Jones, Steven Jacobson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Background and objectivesExtracellular vesicles and particles (EVPs) are released from virtually all cell types, and may package many inflammatory factors and, in the case of infection, viral components. As such, EVPs can play not only a direct role
Externí odkaz:
https://doaj.org/article/abeca7654995444b82a2b718420705a4
Autor:
Pietro Maggi, Colin Vanden Bulcke, Edoardo Pedrini, Céline Bugli, Amina Sellimi, Maxence Wynen, Anna Stölting, William A. Mullins, Grigorios Kalaitzidis, Valentina Lolli, Gaetano Perrotta, Souraya El Sankari, Thierry Duprez, Xu Li, Peter A. Calabresi, Vincent van Pesch, Daniel S. Reich, Martina Absinta
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104701- (2023)
Summary: Background: Chronic active lesions (CAL) in multiple sclerosis (MS) have been observed even in patients taking high-efficacy disease-modifying therapy, including B-cell depletion. Given that CAL are a major determinant of clinical progressio
Externí odkaz:
https://doaj.org/article/71e5da875a874821b8c1a5dacf2164be