Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Daniel S, Lorrain"'
Autor:
Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen, Daniel S. Lorrain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory demyelination that disrupts neuronal transmission resulting in neurodegeneration progressive disability. While current treatments focus on immunosuppress
Externí odkaz:
https://doaj.org/article/968e173534244880bfd928cf16265e56
Autor:
Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan
Publikováno v:
eLife, Vol 5 (2016)
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by si
Externí odkaz:
https://doaj.org/article/4da806c40b4949a2851d1bc03be524f7
Autor:
Daniel S. Lorrain, Ariana O Lorenzana, Alexander Broadhead, Christopher Baccei, Xiong Yifeng, Thomas O. Schrader, Michael M Poon, Karin J. Stebbins
Publikováno v:
ACS Medicinal Chemistry Letters. 12:155-161
The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M1 antagonist, linker replacement and structure-activity relationship investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430b568160efae9b410358b8f2bedc3b
https://doi.org/10.1021/acsmedchemlett.0c00626
https://doi.org/10.1021/acsmedchemlett.0c00626
Autor:
Kim Fischer, Bryan Laffitte, Jason D. Jacintho, Christopher Baccei, Catherine Lee, Karin J. Stebbins, Alex R. Broadhead, Davorka Messmer, Lucia Correa, Daniel S. Lorrain, Peppi Prasit, Austin Chen, Nicholas Simon Stock, Yalda Bravo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:503-508
We previously published on the design and synthesis of novel, potent and selective PPARα antagonists suitable for either i.p. or oral in vivo administration for the potential treatment of cancer. Described herein is SAR for a subsequent program, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e1852f2be64898c0f9b88e9a60a368
https://doi.org/10.1016/j.bmcl.2018.12.045
https://doi.org/10.1016/j.bmcl.2018.12.045
Autor:
Thomas O, Schrader, Yifeng, Xiong, Ariana O, Lorenzana, Alexander, Broadhead, Karin J, Stebbins, Michael M, Poon, Christopher, Baccei, Daniel S, Lorrain
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M(1) antagonist, linker replacement and structure–activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fa8ec81843f4909dda2e384fce0b703
https://pubmed.ncbi.nlm.nih.gov/33488977
https://pubmed.ncbi.nlm.nih.gov/33488977
Autor:
Daniel S. Lorrain, Jonah R. Chan, Kelsey Rankin, Sonia R. Mayoral, Ari J. Green, Sergio E. Baranzini, Riley Bove, Kicheol Kim, Yun-An A Shen, Caroline Desponts, Feng Mei
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 39, iss 12
A significant unmet need for patients with multiple sclerosis (MS) is the lack of U.S. Food and Drug Administration (FDA)-approved remyelinating therapies. We have identified a compelling remyelinating agent, bazedoxifene (BZA), a European Medicines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e38e0b220e3bf6b8bb019244ca101d2
https://escholarship.org/uc/item/969099jq
https://escholarship.org/uc/item/969099jq
Autor:
Jason D. Jacintho, Yalda Bravo, Lucia Correa, Xiao-Jie Yan, Davorka Messmer, Karin J. Stebbins, Geraldine Cabrera, Nicholas Simon Stock, Daniel S. Lorrain, Austin Chen, Nicholas Chiorazzi, Kymmy Lorrain, David Spaner, Peppi Prasit
Publikováno v:
Molecular Medicine. 21:410-419
Tumor-specific metabolic changes can reveal new therapeutic targets. Our findings implicate a supporting role for fatty acid metabolism in chronic lymphocytic leukemia (CLL) cell survival. Peroxisome proliferator–activated receptor (PPAR)-α, a maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d3142a7bb752b7569fb1ae33b5c208
https://doi.org/10.2119/molmed.2015.00139
https://doi.org/10.2119/molmed.2015.00139
Autor:
Jason D. Jacintho, Richard Bundey, Nicholas Simon Stock, Alex R. Broadhead, Karin J. Stebbins, Austin Chen, Ryan C. Clark, Lucia Correa, Yalda Bravo, Christopher Baccei, Peppi Prasit, Davorka Messmer, Daniel S. Lorrain
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2267-2272
The discovery and SAR of a novel series of potent and selective PPARα antagonists are herein described. Exploration of replacements for the labile acyl sulfonamide linker led to a biaryl sulfonamide series of which compound 33 proved to be suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0831ca0312667de4945e3418afd1045
https://doi.org/10.1016/j.bmcl.2014.03.090
https://doi.org/10.1016/j.bmcl.2014.03.090
Autor:
Peppi Prasit, Daniel S. Lorrain, Davorka Messmer, Karin J. Stebbins, Lucia Correa, Austin Chen, Richard Bundey, Geraldine Cabrera, Alex R. Broadhead, Nicholas Simon Stock, Christopher Baccei, Yalda Bravo
Publikováno v:
European journal of pharmacology. 809
Peroxisome-proliferator activated receptors (PPAR) are members of the nuclear hormone receptor superfamily which regulate gene transcription. PPARα is a key regulator of lipid homeostasis and a negative regulator of inflammation. Under conditions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d81a51b31cebff203d417e655669f24
https://pubmed.ncbi.nlm.nih.gov/28483457
https://pubmed.ncbi.nlm.nih.gov/28483457
Autor:
Ari J. Green, J. Josh Lawrence, Lan Xiao, Klaus Lehmann-Horn, Daniel S. Lorrain, Jonah R. Chan, Feng Mei, Jürgen Wess, Karin J. Stebbins, Cory Teuscher, Sharon A. Sagan, H-Christian von Büdingen, Scott S. Zamvil, Kara Pekarek, Stephen P.J. Fancy, Yun-An A Shen, Kelsey Rankin
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496404edbb426ade923167f115d82e1f
https://doi.org/10.7554/elife.18246
https://doi.org/10.7554/elife.18246