Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Daniel Roeth"'
Autor:
Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, E Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton-Jones, Markus Kalkum, Yanhong Shi
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112841- (2023)
Summary: The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer’s disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what t
Externí odkaz:
https://doaj.org/article/77cf8d20e7704cc4ab9715b8179a709d
Autor:
Xiaofang Tang, Yingjun Luo, Dongqiang Yuan, Riccardo Calandrelli, Naseeb Kaur Malhi, Kiran Sriram, Yifei Miao, Chih-Hong Lou, Walter Tsark, Alonso Tapia, Aleysha T. Chen, Guangyu Zhang, Daniel Roeth, Markus Kalkum, Zhao V. Wang, Shu Chien, Rama Natarajan, John P. Cooke, Sheng Zhong, Zhen Bouman Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Impaired angiogenesis in diabetes is a key process contributing to ischemic diseases such as peripheral arterial disease. Epigenetic mechanisms, including those mediated by long noncoding RNAs (lncRNAs), are crucial links connecting diabetes and the
Externí odkaz:
https://doaj.org/article/17124107ddb64a87bca90326d3684d5f
Autor:
Behnam Badie, Chuan He, Mingzi Zhang, Qi Cui, Jeremy Klein, Peng Ye, Yanhong Shi, Haowei Meng, Xiaoting Zhang, Kailin Yin, Jianfei Chao, Guihua Sun, Yue Qin, Marvin Huynhle, Jiangbo Wei, Chengqi Yi, Markus Kalkum, Daniel Roeth, Li Li, Cheng Wang, Xianwei Chen, Leying Zhang
Publikováno v:
Nature Cancer. 2:932-949
Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is highly expressed in glioblastoma versus normal brain tissues, and high PU
Autor:
Qi, Cui, Kailin, Yin, Xiaoting, Zhang, Peng, Ye, Xianwei, Chen, Jianfei, Chao, Haowei, Meng, Jiangbo, Wei, Daniel, Roeth, Li, Li, Yue, Qin, Guihua, Sun, Mingzi, Zhang, Jeremy, Klein, Marvin, Huynhle, Cheng, Wang, Leying, Zhang, Behnam, Badie, Markus, Kalkum, Chuan, He, Chengqi, Yi, Yanhong, Shi
Publikováno v:
Nature cancer. 2(9)
Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is highly expressed in glioblastoma versus normal brain tissues, and high PU
Autor:
Tinisha McDonald, Lucy Ghoda, Alexey V. Danilov, Stacey M. Fernandes, Meiling Jin, Aijun Liao, Jianjun Chen, Lili Wang, Raju Pillai, Markus Kalkum, Steven T. Rosen, Jennifer R. Brown, Mike Fernandez, Yiming Wu, Kevyn Hart, Tanya Siddiqi, Daniel Roeth
Publikováno v:
Blood. 138:499-499
RNA splicing dysregulation is a hallmark of chronic lymphocytic leukemia (CLL). Although somatic mutations in SF3B1 or U1 snRNA present in >20% of CLL patients, general splicing defects cannot be fully explained by genetic alterations of spliceosome
Autor:
Yiming Wu, Jianjun Chen, Jennifer R. Brown, Lili Wang, Tanya Siddiqi, Kevyn Hart, Markus Kalkum, Steven T. Rosen, Tinisha McDonald, Raju Pillai, Meiling Jin, Aijun Liao, Stacey M. Fernandes, Lucy Brown, Daniel Roeth
Publikováno v:
Blood. 136:12-12
Aberrant mRNA processing is known to drive the pathogenesis of chronic lymphocytic leukemia (CLL). Recurrent gene mutations in the RNA splicing factor SF3B1 and widespread RNA intronic polyadenylation impact genome-wide gene expression and inactivate
Autor:
Peera Hemarajata, Daniel Roeth, Sara E. Jones, Markus Kalkum, Jennifer K. Spinler, Delphine M. Saulnier, Matthew D. Burstein, Christina N. Morra, Carissa M. Thomas, Ashley Grimm, Chunxu Gao, Miriam Balderas, James Versalovic
Publikováno v:
MicrobiologyOpen
Bacterial‐derived compounds from the intestinal microbiome modulate host mucosal immunity. Identification and mechanistic studies of these compounds provide insights into host–microbial mutualism. Specific Lactobacillus reuteri strains suppress p
Autor:
Wei Chen, David M Patrick, Natalia R Barbaro, Kenneth E Bernstein, Daniel Roeth, Markus Kalkum, Liang Xiao, Annet Kirabo, David G Harrison
Publikováno v:
Hypertension. 72
We and others have shown an important role CD8+ cells in both experimental and human hypertension. CD8+ T cells are activated by antigens presented by major histocompatibility complex 1 (MHC1). C57BL/6 mice express two MHC1, referred to as H2-Kb and
Akademický článek
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Publikováno v:
Free Radical Biology and Medicine. 49:S147