Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniel Robert, Roth"'
Autor:
Daniel Robert Roth, Conrad E. Johanson, Edward G. Stopa, Juergen Funk, Georg Krinke, Paul N. McMillan
Publikováno v:
Toxicologic Pathology. 39:186-212
Bordering the ventricular cerebrospinal fluid (CSF) are epithelial cells of choroid plexus (CP), ependyma and circumventricular organs (CVOs) that contain homeostatic transporters for mediating secretion/reabsorption. The distributional pathway (“n
Publikováno v:
Laboratory Animals. 44:352-358
In a large number of animal experiments, blood collection is crucial for achieving the study aim. Requirements on sampling techniques used include their practicability, their effectiveness in terms of obtaining the desired blood volume, sample qualit
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies
Autor:
Francois Pognan, Min Dong, Armin Wolf, Ursula Junker, Jeffrey Tsao, David Ledieu, Ulrich W. Laengle, Danielle Roman, Anja Nussher, Olivier Grenet, Christian Trendelenburg, Gilles-Jacques Riviere, Philippe Couttet, Estelle Marrer, Elke Persohn, Marcia Heron, Daniel Robert Roth
Publikováno v:
Leukemia Research. 34:1180-1188
Cytotoxic concentrations of imatinib mesylate (10–50 μM) were required to trigger markers of apoptosis and endoplasmic reticulum stress response in neonatal rat ventricular myocytes and fibroblasts, with no significant differences observed between
Autor:
Daniel J. Holder, Douglas Thudium, Francois Legay, P. F. Verdes, Salah-Dine Chibout, Warren E. Glaab, Sean P. Troth, Frank D. Sistare, Wendy J. Bailey, Andreas Mahl, Frank Staedtler, David Gerhold, Katerina Vlasakova, Michael J Topper, Hong Jin, Frank Dieterle, Daniel Robert Roth, Gerard Maurer, Zoltan Erdos, Spencer Reynolds, Daniel Wahl, Yan Yu, Joseph F. Sina, André Cordier, Tom Forest, Elias Perentes, Holly K Clouse, Thomas R. Skopek, Olivier Grenet, Jacky Vonderscher, Nagaraja Muniappa, Josef S Ozer
Publikováno v:
Nature Biotechnology. 28:486-494
The Predictive Safety Testing Consortium's first regulatory submission to qualify kidney safety biomarkers revealed two deficiencies. To address the need for biomarkers that monitor recovery from agent-induced renal damage, we scored changes in the l
Publikováno v:
Experimental and Toxicologic Pathology. 60:247-251
Meningioangiomatosis is a rare proliferative disorder of the central nervous system. Several cases have been described in humans, a few in dogs, one case in a cow and one in a horse; meningioangiomatosis has never been recorded in rodents. The pathog
Publikováno v:
Experimental and Toxicologic Pathology. 60:263-267
Spontaneous meningiomas are extremely rare tumors in small laboratory animals, except in some strains of rats and in the B6C3F1 mouse. We report the case of a male CD-1 mouse in poor health condition, with severe apathy and partial paresis of hindleg
Autor:
Daniel Robert Roth, Ursula Junker, Elias Perentes, Danielle Roman, Peter Ulrich, Andreas Mahl
Publikováno v:
Experimental and Toxicologic Pathology. 57:367-371
The evaluation of potential adverse effects of pharmaceuticals on the immune system is part of the standard drug development procedures and needs to be available prior to the start of phase III clinical trials. Although the histopathological assessme
Autor:
M. Gerard O'Sullivan, Christine Ruehl-Fehlert, Daniel Robert Roth, Gerd Morawietz, Jan Klapwijk, Peter F. Wadsworth, Birgit Kittel, Michael R. Elwell, Barbara Lenz
Publikováno v:
Experimental and Toxicologic Pathology. 55:413-431
This is the second part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the respiratory, male and female genital, and the endocrine systems. The article
Autor:
Danielle Roman, Brigitte Greiner, Ralf Brandt, Thanongsak Mamom, Daniel Robert Roth, Wolfgang Seewald, Robert Cozens, Paul-Georg Germann, Fritz Wenger
Publikováno v:
Experimental and Toxicologic Pathology. 55:237-245
Summary The aim of the study was to determine the effects of a specific epithelial growth factor Receptor kinase inhibitor (EGFR-KI) and Taxol on tumor growth in a novel tumor model. Material & methods: A genetically engineered tumor model which uses
Autor:
Daniel Robert Roth, Elias Perentes
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 64(3)
Microscopic examination of the heart of a clinically normal 14-month-old female Beagle dog revealed the presence of ectopic thyroid tissue at the base of the heart, around the aorta, and intracardially at the level of the left ventricle and the aorti