Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Daniel R. Wahl"'
Autor:
Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica Lin, Alexandra O’Brien, Ayesha Kothari, Zitong Zhao, Li Zhang, Meredith A. Morgan, Sriram Venneti, Carl Koschmann, Nada Jabado, Costas A. Lyssiotis, Maria G. Castro, Daniel R. Wahl
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M
Externí odkaz:
https://doaj.org/article/1951e061c7ab4540990fd8c2ffa35723
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.
Externí odkaz:
https://doaj.org/article/0d2d630dc0a747b8807be46604e76da1
Autor:
Nicholas R. Rydzewski, Erik Peterson, Joshua M. Lang, Menggang Yu, S. Laura Chang, Martin Sjöström, Hamza Bakhtiar, Gefei Song, Kyle T. Helzer, Matthew L. Bootsma, William S. Chen, Raunak M. Shrestha, Meng Zhang, David A. Quigley, Rahul Aggarwal, Eric J. Small, Daniel R. Wahl, Felix Y. Feng, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, w
Externí odkaz:
https://doaj.org/article/683460200e2546bd8518fb156fad7efa
Autor:
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcom
Externí odkaz:
https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba
Autor:
Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through
Externí odkaz:
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Simple SummaryGlioblastoma (GBM) is the most common and aggressive primary brain tumor. Diffusion kurtosis imaging (DKI) has characterized non-Gaussian diffusion behaviors in brain normal tissue and gliomas, but there are very limited efforts in inve
Externí odkaz:
https://doaj.org/article/3f22044adb9b4c7fa139b9aab9d9bd3e
Autor:
Navyateja Korimerla, Daniel R. Wahl
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1919 (2022)
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a comm
Externí odkaz:
https://doaj.org/article/4e0ae8f29819400a9512f9cd151e6bdd
Autor:
Corey Speers, Shuang G. Zhao, Ben Chandler, Meilan Liu, Kari Wilder-Romans, Eric Olsen, Shyam Nyati, Cassandra Ritter, Prasanna G. Alluri, Vishal Kothari, Daniel F. Hayes, Theodore S. Lawrence, Daniel E. Spratt, Daniel R. Wahl, Lori J. Pierce, Felix Y. Feng
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-10 (2017)
Radiation: Drug target found for radioresistance Drugs that block the androgen receptor (AR) protein can help make radiation-resistant breast tumors susceptible to ionizing therapy. Corey Speers from the University of Michigan, Ann Arbor, USA, and co
Externí odkaz:
https://doaj.org/article/c2e0158317ef4f30b527bc09f5771091
Autor:
Weihua Zhou, Daniel R. Wahl
Publikováno v:
Cancers, Vol 11, Iss 9, p 1231 (2019)
Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the stand
Externí odkaz:
https://doaj.org/article/86b9b59b64544ab9beed9df32f7c0c5e
Autor:
Dionysios C. Watson, Defne Bayik, Simon Storevik, Shannon Sherwin Moreino, Samuel A. Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Palavalasa Sravya, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R. Lunavat, Daniel J. Silver, Sahil Dayal, Justin Vareecal Joseph, Erin Mulkearns-Hubert, Lars Andreas Rømo Ystaas, Gauravi Deshpande, Joris Guyon, Yadi Zhou, Capucine R. Magaut, Juliana Seder, Laura Neises, Sarah E. Williford, Johannes Meiser, Andrew J. Scott, Peter Sajjakulnukit, Jason A. Mears, Rolf Bjerkvig, Abhishek Chakraborty, Thomas Daubon, Feixiong Cheng, Costas A. Lyssiotis, Daniel R. Wahl, Anita B. Hjelmeland, Jubayer A. Hossain, Hrvoje Miletic, Justin D. Lathia
Publikováno v:
Nature Cancer. 4:648-664
The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly understood. Here we show that mit