Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Daniel R. Southworth"'
Autor:
Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C. Thwin, Koli Basu, Matthew D. Callahan, Daniel R. Southworth, Daniel A. Mordes, Charles S. Craik, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-pho
Externí odkaz:
https://doaj.org/article/65e099c2e88a4ef08f3a505a925ec40b
Autor:
Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk
Externí odkaz:
https://doaj.org/article/aac87a63fb79463b9e1a637cad62d4a9
Autor:
Gregory E. Merz, Matthew J. Chalkley, Sophia K. Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado, Daniel R. Southworth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of Alzheimer’s disease (AD) and many other neurodegenerative tauopathies. The filaments adopt disease-specific cross-β amyloid conformations tha
Externí odkaz:
https://doaj.org/article/4d453a94c2d04d8b84481f4520c5fd9e
Autor:
Alexandrea N. Rizo, JiaBei Lin, Stephanie N. Gates, Eric Tse, Stephen M. Bart, Laura M. Castellano, Frank DiMaio, James Shorter, Daniel R. Southworth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Bacterial ClpB is a disaggregase that solubilizes protein aggregates. Here the authors present the 2.9 Å cryo-EM structure of a hyperactive variant of ClpB bound to the substrate casein in active translocation states and discuss its polypeptide tran
Externí odkaz:
https://doaj.org/article/4b26b48e90114f5a86fdb8eed991c130
Autor:
Filipa Teixeira, Eric Tse, Helena Castro, Karl A. T. Makepeace, Ben A. Meinen, Christoph H. Borchers, Leslie B. Poole, James C. Bardwell, Ana M. Tomás, Daniel R. Southworth, Ursula Jakob
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Many 2-Cystein Peroxiredoxins (Prx) can either function as peroxidases or chaperones when exposed to stress. Here the authors present the structures of Leishmania infantum mitochondrial Prx alone and with a bound model client protein, use crosslinkin
Externí odkaz:
https://doaj.org/article/df1a8fb0297f4c10ab0f61d7773553d4
Autor:
Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.
Externí odkaz:
https://doaj.org/article/ea828c6ee26840cd8de08621cb5f0b7d
Autor:
Amber Tariq, JiaBei Lin, Meredith E. Jackrel, Christina D. Hesketh, Peter J. Carman, Korrie L. Mack, Rachel Weitzman, Craig Gambogi, Oscar A. Hernandez Murillo, Elizabeth A. Sweeny, Esin Gurpinar, Adam L. Yokom, Stephanie N. Gates, Keolamau Yee, Saurabh Sudesh, Jacob Stillman, Alexandra N. Rizo, Daniel R. Southworth, James Shorter
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2080-2095.e6 (2019)
Summary: Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-synuclein implicated in fatal neurodegenerative disorders. Pr
Externí odkaz:
https://doaj.org/article/bf589229a4c8478bb067db7496f89daf
Autor:
Shirish Shukla, Uday Sankar Allam, Aarif Ahsan, Guoan Chen, Pranathi Meda Krishnamurthy, Katherine Marsh, Matthew Rumschlag, Sunita Shankar, Christopher Whitehead, Matthew Schipper, Venkatesha Basrur, Daniel R. Southworth, Arul M. Chinnaiyan, Alnawaz Rehemtulla, David G. Beer, Theodore S. Lawrence, Mukesh K. Nyati, Dipankar Ray
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 2, Pp 115-128 (2014)
Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex maintaining KRAS protein stability. Loss of SMURF2 either by small int
Externí odkaz:
https://doaj.org/article/337e778e43f7471c962968f288517f18
Autor:
Kelly M. Montgomery, Emma C. Carroll, Aye C. Thwin, Athena Y. Quddus, Paige Hodges, Daniel R. Southworth, Jason E. Gestwicki
Publikováno v:
Journal of the American Chemical Society. 145:3926-3936
Publikováno v:
bioRxiv
The mitochondrial chaperonin, mtHsp60, promotes the folding of newly imported and transiently misfolded proteins in the mitochondrial matrix, assisted by its co-chaperone mtHsp10. Despite its essential role in mitochondrial proteostasis, structural i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc66dfdca3c2c19723f4306887408fa
https://europepmc.org/articles/PMC10245740/
https://europepmc.org/articles/PMC10245740/