Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Daniel R. Sidler"'
Autor:
Edward C. Sherer, Zhen Li, Daniel Zewge, Gabor Butora, Ian W. Davies, Joseph D. Armstrong, Greg Copeland, David M. Tellers, Joseph R. Gouker, Daniel R. Sidler, Vasant Jadhav
Publikováno v:
Bioconjugate chemistry. 29(6)
An efficient multicomponent orthogonal protocol was developed for post-synthetic oligonucleotide modification using commercially available 2'- O-methyl ester and 2'- O-propargyl nucleoside scaffolds. Amidation of methyl esters with primary amines was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36334fa0cc0b41aa5749ac2eaf41872
https://pubmed.ncbi.nlm.nih.gov/29893553
https://pubmed.ncbi.nlm.nih.gov/29893553
Autor:
Louis Matty, Kozo Gbewonyo, Wenjie Li, Hu Essa H, Paul J. Reider, Michel Chartrain, Daniel R. Sidler, Russell Boyd, Edward G. Corley, Jeffrey S. Campbell, Nori Ikemoto, Robert D. Larsen, Richard G. Ball, Nancy Barta
Publikováno v:
Canadian Journal of Chemistry. 80:646-652
The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::036b92db4e774125c2e875505052b452
https://doi.org/10.1139/v02-079
https://doi.org/10.1139/v02-079
Autor:
Nancy Sue Barta, Steven A. Weissman, Paul J. Reider, Kara B. Somerville, Daniel R. Sidler, Robert D. Larsen
Publikováno v:
Organic Letters. 2:2821-2824
[reaction: see text] Chiral oxazolidin-2-ones are synthetically valuable as chiral auxiliaries, and many have pharmaceutically interesting biological activity. This communication focuses on a convenient, practical one-pot preparation of chiral 4,5-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2391165dbffb5305d4e5339326bd8a
https://doi.org/10.1021/ol006255z
https://doi.org/10.1021/ol006255z
Publikováno v:
The Journal of Organic Chemistry. 63:3454-3457
In the past decade, 4-aryl-dihydropyrimidinones 1 have emerged as the integral backbones of several calcium channel blockers, antihypertensive agents, and alpha-1 a-antagonists.1 Strategies for the synthesis of the dihydropyrimidinone nucleus have va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53405d61319acc0e75d6071b950b83f4
https://doi.org/10.1021/jo970846u
https://doi.org/10.1021/jo970846u
Publikováno v:
Tetrahedron: Asymmetry. 8:161-168
An efficient, 9-step synthesis of LTD 4 antagonist L-708,738 is described. The asymmetric center is set via a chiral borane reduction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88dea825d7898e3bde55f67252913c3f
https://doi.org/10.1016/s0957-4166(96)00499-5
https://doi.org/10.1016/s0957-4166(96)00499-5
Autor:
G. Bicker, George B. Smith, P. Tway, John O. Egekeze, Holly J. Perpall, Daniel R. Sidler, Michael C. Danielski, Nelu Grinberg
Publikováno v:
Analytical Chemistry. 67:2292-2295
The inherent instability of active esters provides a chromatographic challenge. A normal phase HPLC gradient was developed using nonprotic solvents and a diol stationary phase to determine the impurity profile of a mesylate which, under protic condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d2a7668c369d176ee1bbc93fba84cd
https://doi.org/10.1021/ac00109a059
https://doi.org/10.1021/ac00109a059
Autor:
J. S. Amato, M. Bhupathy, J. L. Leazer, J. J. Bergan, David L. Hughes, Daniel R. Sidler, Paul J. Reider, Edward J. J. Grabowski, James M. McNamara
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47d9285a1c060630f4316ee7bff12aa
https://doi.org/10.1002/chin.199126089
https://doi.org/10.1002/chin.199126089
Autor:
James M. McNamara, Paul J. Reider, David L. Hughes, Robert A. Reamer, Edward J. J. Grabowski, J. L. Leazer, Ichiro Shinkai, J. J. Bergan, T. C. Lovelace, J. S. Amato, M. Bhupathy, Daniel R. Sidler
Publikováno v:
ChemInform. 24
A practical, chemoenzymatic, four-step synthesis of the LTD4 antagonist MK-0679 is described. The key steps are enzymatic hydrolysis of the prochiral diester to the ester-acid in 99% enantiomeric excess followed by aluminum mediated amidation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8e92f1260563978d92a093f5d4e188
https://doi.org/10.1002/chin.199311337
https://doi.org/10.1002/chin.199311337
Publikováno v:
ChemInform. 25
The preparation and characterization of N,N-dimethylammonium dialkylaluminum chloride and the use of these complexes in the synthesis of the LTD 4 antagonist MK-0679 is described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da59b634bde0f1a90f5094f5969cd72f
https://doi.org/10.1002/chin.199433108
https://doi.org/10.1002/chin.199433108
Publikováno v:
ChemInform. 28
An efficient, 9-step synthesis of LTD 4 antagonist L-708,738 is described. The asymmetric center is set via a chiral borane reduction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51b2f4fe8273b9c86aaf6e2280ffe2e6
https://doi.org/10.1002/chin.199719154
https://doi.org/10.1002/chin.199719154