Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Daniel R. Neill"'
Autor:
Laura C. Jacques, Angharad E. Green, Thomas E. Barton, Murielle Baltazar, Julia Aleksandrowicz, Rong Xu, Erwan Trochu, Aras Kadioglu, Daniel R. Neill
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The short generation time of many bacterial pathogens allows the accumulation of de novo mutations during routine culture procedures used for the preparation and propagation of bacterial stocks. Taking the major human pathogen Streptococcus
Externí odkaz:
https://doaj.org/article/de92f347b347461c935269ceef1608a9
Autor:
Rong Xu, Laura C. Jacques, Shadia Khandaker, Daan Beentjes, Miguel Leon-Rios, Xiaoqing Wei, Neil French, Daniel R. Neill, Aras Kadioglu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112054- (2023)
Summary: Streptococcus pneumoniae is a pathogen of global morbidity and mortality. Pneumococcal pneumonia can lead to systemic infections associated with high rates of mortality. We find that, upon pneumococcal infection, pulmonary Treg cells are act
Externí odkaz:
https://doaj.org/article/5bd0903ad9fd4e9e86620d19bbfddae3
Autor:
Chowdhury M. Hasan, Sian Pottenger, Angharad E. Green, Adrienne A. Cox, Jack S. White, Trevor Jones, Craig Winstanley, Aras Kadioglu, Megan H. Wright, Daniel R. Neill, Joanne L. Fothergill
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Pseudomonas aeruginosa undergoes diversification during infection of the cystic fibrosis (CF) lung. Understanding these changes requires model systems that capture the complexity of the CF lung environment. We previously identified loss-of-function m
Externí odkaz:
https://doaj.org/article/22204499f90d4a298bfea430f8163726
Autor:
Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, Aras Kadioglu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal car
Externí odkaz:
https://doaj.org/article/a8bb4f2f12d842e99dc75046011d68e1
Autor:
Laura C. Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Rong Xu, Laura Bricio-Moreno, Marie Yang, Christopher G. Dowson, Dean B. Everett, Daniel R. Neill, Aras Kadioglu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight j
Externí odkaz:
https://doaj.org/article/4e3fa97f73434e33a5cdb4df33c7b5d6
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains. Antimicrobial-resistant nosocomial pathogens such as P. aeruginosa
Externí odkaz:
https://doaj.org/article/3258fe7fab244c2fa9168b384328561f
Autor:
Laura Bricio-Moreno, Chrispin Chaguza, Reham Yahya, Rebecca K. Shears, Jennifer E. Cornick, Karsten Hokamp, Marie Yang, Daniel R. Neill, Neil French, Jay C. D. Hinton, Dean B. Everett, Aras Kadioglu
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Streptococcus pneumoniae is a frequent colonizer of the human nasopharynx and a major cause of life-threating invasive infections such as pneumonia, meningitis and sepsis. Over 1 million people die every year due to invasive pneumococcal dis
Externí odkaz:
https://doaj.org/article/d130bf11bdac4f6db9ab76bb89201d2d
Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
Autor:
Laura Bricio-Moreno, Victoria H. Sheridan, Ian Goodhead, Stuart Armstrong, Janet K.L. Wong, Elaine M. Waters, Joscelyn Sarsby, Stavros Panagiotou, James Dunn, Adrita Chakraborty, Yongliang Fang, Karl E. Griswold, Craig Winstanley, Joanne L. Fothergill, Aras Kadioglu, Daniel R. Neill
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mutations in gene pmrB are found in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Here, Bricio-Moreno et al. show in a mouse model of respiratory infection that the mutations enhance bacterial adherence to epithelial cells and resist
Externí odkaz:
https://doaj.org/article/dc57b3200e764343a7284314e6587068
Publikováno v:
ACS Applied Materials & Interfaces. 15:20822-20832
Publikováno v:
Am J Respir Crit Care Med
Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia and bacterial meningitis. A number of recent studies indicate an association between the incidence of pneumococcal disease and exposure to air pollution. Although the epide