Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel R. McDougle"'
Autor:
Joseph A. Cacioppo, Po-Ching Patrick Lin, Patrick R. Hannon, Daniel R. McDougle, Arnon Gal, CheMyong Ko
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Ovulation is dependent upon numerous factors mediating follicular growth, vascularization, and ultimately oocyte release via follicle rupture. Endothelin-2 (EDN2) is a potent vasoconstrictor that is transiently produced prior to follicle rup
Externí odkaz:
https://doaj.org/article/c60aa4525a74446b848c5da148aeb77f
Autor:
Grzegorz Bulaj, Misty D. Smith, Cameron S. Metcalf, Daniel R. McDougle, Brian D. Klein, Liuyin Zhang
Publikováno v:
Neurochemical Research. 42:1983-1994
The potential clinical utility of galanin peptidic analogs has been hindered by poor metabolic stability, lack of brain penetration, and hyperglycemia. In addition to possessing potent anticonvulsant efficacy, galanin analogs are analgesic in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9778df9c43ed244f22a0c0edd53605bb
https://doi.org/10.1007/s11064-017-2229-5
https://doi.org/10.1007/s11064-017-2229-5
Autor:
Grzegorz Bulaj, Daniel R. McDougle, Liuyin Zhang, Cameron S. Metcalf, Dan Kaufmann, Brian D. Klein, H. Steve White
Publikováno v:
Epilepsia. 58:239-246
SummaryObjective Potential clinical utility of galanin or peptidic analogs has been hindered by poor metabolic stability, lack of brain penetration, and hyperglycemia due to galanin receptor subtype 1 (GalR1) activation. NAX 810-2, a galanin receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5f10902162378c5d834780ef18f994
https://doi.org/10.1111/epi.13647
https://doi.org/10.1111/epi.13647
Autor:
Michael Holinstat, Daniel R. McDougle, Aditi Das, Megan P. Caputo, Reheman Adili, Kristopher A. Kilian, Amr A. Abdeen, Rodney W. Johnson, Josephine E. Watson, John E. Krapf
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Clinical studies suggest that diets rich in ω-3 polyunsaturated fatty acids (PUFAs) provide beneficial anti-inflammatory effects, in part through their conversion to bioactive metabolites. Here we report on the endogenous production of a previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f363fa1957977bec3356ac8e25b04a67
https://doi.org/10.1073/pnas.1610325114
https://doi.org/10.1073/pnas.1610325114
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:616-627
The endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are arachidonic acid (AA) derivatives that are known to regulate human cardiovascular functions. CYP2J2 is the primary cytochrome P450 in the human heart and is most well known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7493c84a67a6f46e7efdf6a594e44f15
https://doi.org/10.1124/jpet.114.216598
https://doi.org/10.1124/jpet.114.216598
Publikováno v:
Protein Science. 22:964-979
CYP2J2 epoxygenase is a membrane bound cytochrome P450 that converts omega-3 and omega-6 fatty acids into physiologically active epoxides. In this work, we present a comprehensive comparison of the effects of N-terminal modifications on the propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99aa93f43215755e85c557c08114115b
https://doi.org/10.1002/pro.2280
https://doi.org/10.1002/pro.2280
Autor:
Brad R. Green, Grzegorz Bulaj, Liuyin Zhang, Erika A. Scholl, Karen White, Daniel R. McDougle, Timothy H. Pruess, H. Steve White, Brian D. Klein
Publikováno v:
Journal of Peptide Science. 16:486-495
The neuropeptides galanin (GAL), neuropeptide Y (NPY) or neurotensin (NT) exhibit anticonvulsant activities mediated by their respective receptors in the brain. To transform these peptides into potential neurotherapeutics, their systemic bioavailabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::948519ebcf72788937466e2e333cfd6e
https://doi.org/10.1002/psc.1266
https://doi.org/10.1002/psc.1266
Publikováno v:
Journal of the American Chemical Society. 138(1)
Semiconductor nanoplatelets (NPLs) are planar nanocrystals that have recently attracted considerable attention due to their quantum-well-like physics, atomically precise thickness, and unique photophysical properties such as narrow-band fluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc31b6b191ed5c0fbf790ad4e0225628
https://pubmed.ncbi.nlm.nih.gov/26687504
https://pubmed.ncbi.nlm.nih.gov/26687504
Autor:
Daniel R. McDougle, H. Steve White, Liuyin Zhang, Brian D. Klein, Misty D. Smith, Grzegorz Bulaj, Cameron S. Metcalf
There are ongoing efforts to develop pain therapeutics with novel mechanisms of action that avoid common side effects associated with other analgesics. The anticonvulsant neuropeptide galanin is a potent regulator of neuronal excitability and has a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c851f90a175c8185071ca6bbdb7e1144
https://europepmc.org/articles/PMC4279104/
https://europepmc.org/articles/PMC4279104/
Autor:
Brian D. Klein, Cameron S. Metcalf, Grzegorz Bulaj, Liuyin Zhang, H. Steve White, Daniel R. McDougle
Publikováno v:
Neuropeptides. 65:150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c75b2706283e137140baa040fe72265
https://doi.org/10.1016/j.npep.2017.02.071
https://doi.org/10.1016/j.npep.2017.02.071