Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Daniel R. Crooks"'
Autor:
Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Morís, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype of sporadic RCC tha
Externí odkaz:
https://doaj.org/article/6b0458681f774fc788c19d8f3ed9c6d2
Autor:
Kate Brown, Lisa M. Miller Jenkins, Daniel R. Crooks, Deborah R. Surman, Sharlyn J. Mazur, Yuan Xu, Bhargav S. Arimilli, Ye Yang, Andrew N. Lane, Teresa W-M. Fan, David S. Schrump, W. Marston Linehan, R. Taylor Ripley, Ettore Appella
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
TP53 is the most commonly mutated gene in cancer, and gain-of-function mutations have wide-ranging effects. Efforts to reactivate wild-type p53 function and inhibit mutant functions have been complicated by the variety of TP53 mutations. Identified f
Externí odkaz:
https://doaj.org/article/c07b755597a5468588906ab014a43c40
Autor:
Kazutoshi Yamamoto, Ana Opina, Deepak Sail, Burchelle Blackman, Keita Saito, Jeffrey R. Brender, Ronja M. Malinowski, Tomohiro Seki, Nobu Oshima, Daniel R. Crooks, Shun Kishimoto, Yu Saida, Yasunori Otowa, Peter L. Choyke, Jan H. Ardenkjær-Larsen, James B. Mitchell, W. Marston Linehan, Rolf E. Swenson, Murali C. Krishna
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Drastic sensitivity enhancement of dynamic nuclear polarization is becoming an increasingly critical methodology to monitor real-time metabolic and physiological information in chemistry, biochemistry, and biomedicine. However, the limited n
Externí odkaz:
https://doaj.org/article/bad8b5268826453db750b84fe20d286f
Autor:
Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan, Jeffrey A. Moscow
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Background The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms leading to upregulation o
Externí odkaz:
https://doaj.org/article/0dceb078fdad4b62bc2e715b95444bdb
Autor:
Penghui Lin, Li Dai, Daniel R. Crooks, Leonard M. Neckers, Richard M. Higashi, Teresa W-M. Fan, Andrew N. Lane
Publikováno v:
Metabolites, Vol 11, Iss 4, p 202 (2021)
Lipids comprise diverse classes of compounds that are important for the structure and properties of membranes, as high-energy fuel sources and as signaling molecules. Therefore, the turnover rates of these varied classes of lipids are fundamental to
Externí odkaz:
https://doaj.org/article/82594f81172c475ba83f4c680d3e2888
Publikováno v:
Anal Chem
Biologically important 2-hydroxy carboxylates such as lactate, malate, and 2-hydroxyglutarate exist in two enantiomeric forms that cannot be distinguished under achiral conditions. The D and L (or R, S) enantiomers have different biological origins a
Autor:
Shun Kishimoto, Jeffrey R Brender, Daniel R Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed, Albert P Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L Choyke, James Mitchell, Andrew N Lane, Teresa WM Fan, W Marston Linehan, Murali C Krishna
Publikováno v:
eLife, Vol 8 (2019)
Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we dem
Externí odkaz:
https://doaj.org/article/55e2be4d50894222ab3e33462c3754bc
Autor:
Christina M. Fitzsimmons, Mariana D. Mandler, Judith C. Lunger, Dalen Chan, Siddhardha S. Maligireddy, Alexandra C. Schmiechen, Supuni Thalalla Gamage, Courtney Link, Lisa M. Jenkins, Daniel R. Crooks, Jordan L. Meier, W. Marston Linehan, Pedro J. Batista
Metabolic reprogramming is a hallmark of cancer that facilitates changes in many adaptive biological processes. Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) lead to fumarate accumulation and cause hereditary leiomyom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf2c3915f7b605357eb17693dbf351c
https://doi.org/10.1101/2023.04.10.536262
https://doi.org/10.1101/2023.04.10.536262
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
RNAse Esc2 TXNIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cb2352cf6ee8517ba836977219d285
https://doi.org/10.1158/1535-7163.22505272.v1
https://doi.org/10.1158/1535-7163.22505272.v1
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e340b99ca40389ffa9f98c0fced22dc
https://doi.org/10.1158/1535-7163.c.6538015.v1
https://doi.org/10.1158/1535-7163.c.6538015.v1