Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel R. Albaugh"'
Autor:
Xiang Li, Hidenori Takahashi, Steven S. Pullen, Stéphane De Lombaert, Asitha Abeywardane, Ming-Hong Hao, John R. Proudfoot, Anil Kumar Padyana, Brandon Collins, Leslie Martin, Daniel R. Albaugh, Steven John Taylor, Shuang Liang, Bennett Sandy Farmer, Melissa Hill-Drzewi
Publikováno v:
Journal of Medicinal Chemistry. 56:4465-4481
Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f937968f315ebdb6231db492a5253462
https://doi.org/10.1021/jm400138z
https://doi.org/10.1021/jm400138z
Autor:
Dennis W. Hill, Steven Lai, Hank K. Ng, Clive L. Baveghems, Tzipporah M. Kormos, Daniel R. Albaugh, David F. Grant
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:2303-2310
RATIONALE The determination of the center-of-mass energy at which 50% of a precursor ion decomposes (Ecom50) during collision-induced dissociation (CID) is dependent on the chemical structure of the ion as well as the physical and electrical characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e5834db561437f94802288dd13f280
https://doi.org/10.1002/rcm.6353
https://doi.org/10.1002/rcm.6353
Publikováno v:
Drug Metabolism and Disposition. 40:1336-1344
The current studies assessed the utility of freshly plated hepatocytes, cryopreserved plated hepatocytes, and cryopreserved plated HepaRG cells for the estimation of inactivation parameters k(inact) and K(I) for CYP3A. This was achieved using a subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1643820b66b73e1b2864785bea6551
https://doi.org/10.1124/dmd.112.044644
https://doi.org/10.1124/dmd.112.044644
Autor:
Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df6a496eb118478cab46c6fde2569f9
https://doi.org/10.1016/j.bmcl.2011.05.126
https://doi.org/10.1016/j.bmcl.2011.05.126
Autor:
Daniel R. Albaugh, David F. Grant, Tzipporah M. Kertesz, Lowell H. Hall, Dennis W. Hill, L. Mark Hall
Publikováno v:
Bioanalysis. 1:1627-1643
MS and HPLC are commonly used for compound characterization and obtaining structural information; in the field of metabonomics, these two analytical techniques are often combined to characterize unknown endogenous or exogenous metabolites present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8715a7123755aecae52a4ea85810b6b1
https://doi.org/10.4155/bio.09.145
https://doi.org/10.4155/bio.09.145
Publikováno v:
Drug Metabolism Letters. 3:78-82
To provide a fast and quantitative assessment of CYP inactivation in the drug discovery stage, a mathematical model was derived to calculate enzyme inactivation parameters, k(inact) and K(I), based on experimental data obtained from 2 concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e17ef6e937280b5808ab2133f6ddaec
https://doi.org/10.2174/187231209788654063
https://doi.org/10.2174/187231209788654063
Autor:
Michael B. Fisher, Daniel R. Albaugh
Publikováno v:
Handbook of Metabolic Pathways of Xenobiotics
As strategies are employed in pharmaceutical research to optimize chemical space for low clearance via oxidative pathways, metabolism via conjugating enzymes is becoming more important. Indeed, clearance pathways involving glucuronidation, sulfation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32568ed2b4030e755de8defbec76c1eb
https://doi.org/10.1002/9781118541203.xen0013
https://doi.org/10.1002/9781118541203.xen0013
Autor:
Young-Sun Yang, Cody L. Fullenwider, Jennifer Schmenk, Michael Fisher, J. Matthew Hutzler, Daniel R. Albaugh
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(2)
Substrates of aldehyde oxidase (AO), for which human clinical pharmacokinetics are reported, were selected and evaluated in pooled mixed-gender cryopreserved human hepatocytes in an effort to quantitatively characterize AO activity. Estimated hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266e930d34e95b3f30b1bde03962b867
https://pubmed.ncbi.nlm.nih.gov/22031625
https://pubmed.ncbi.nlm.nih.gov/22031625
Autor:
Dennis W. Hill, Daniel R. Albaugh, L. Mark Hall, David F. Grant, Lowell H. Hall, Marc Parham, Tzipporah M. Kertesz
Publikováno v:
Journal of chemical information and modeling. 49(4)
A back-propagation artificial neural network (ANN) was used to create a 10-fold leave-10%-out cross-validated ensemble model of high performance liquid chromatography retention index (HPLC-RI) for a data set of 498 diverse druglike compounds. A 10-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2391dcb850c88b9f94be5757da398f
https://pubmed.ncbi.nlm.nih.gov/19309176
https://pubmed.ncbi.nlm.nih.gov/19309176
Autor:
Daniel R. Albaugh, L. Mark Hall, Dennis W. Hill, Tzipporah M. Kertesz, Marc Parham, Lowell H. Hall, David F. Grant
Publikováno v:
Journal of Chemical Information & Modeling; Apr2009, Vol. 49 Issue 4, p788-799, 12p