Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Daniel R Ripoll"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008864 (2021)
High-throughput B-cell sequencing has opened up new avenues for investigating complex mechanisms underlying our adaptive immune response. These technological advances drive data generation and the need to mine and analyze the information contained in
Externí odkaz:
https://doaj.org/article/67a41a9e057444e395ba458eda83019f
Autor:
Sidhartha Chaudhury, Gregory D Gromowski, Daniel R Ripoll, Ilja V Khavrutskii, Valmik Desai, Anders Wallqvist
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a centra
Externí odkaz:
https://doaj.org/article/fa9414519755456db726302c20606355
Autor:
Jeffrey W Koehler, Jeffrey M Smith, Daniel R Ripoll, Kristin W Spik, Shannon L Taylor, Catherine V Badger, Rebecca J Grant, Monica M Ogg, Anders Wallqvist, Mary C Guttieri, Robert F Garry, Connie S Schmaljohn
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2430 (2013)
For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is mediated by at least three classes of fusion proteins (Class I, II, and III) based on the protein seq
Externí odkaz:
https://doaj.org/article/09d6224846cf4a5fbeb41724368b59d4
Autor:
Daniel R Ripoll, Ilja V Khavrutskii, Sidhartha Chaudhury, Jin Liu, Robert A Kuschner, Anders Wallqvist, Jaques Reifman
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002665 (2012)
Quantitatively predicting changes in drug sensitivity associated with residue mutations is a major challenge in structural biology. By expanding the limits of free energy calculations, we successfully identified mutations in influenza neuraminidase (
Externí odkaz:
https://doaj.org/article/c990e87185354733a26e436e70ef2d5b
Autor:
Tom Martin, Shun-Wen Lu, Herman van Tilbeurgh, Daniel R Ripoll, Christina Dixelius, B Gillian Turgeon, Robert Debuchy
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15199 (2010)
BackgroundFungal mating types in self-incompatible Pezizomycotina are specified by one of two alternate sequences occupying the same locus on corresponding chromosomes. One sequence is characterized by a gene encoding an HMG protein, while the hallma
Externí odkaz:
https://doaj.org/article/1442b975d4c84ffaab91193e13258027
Autor:
Daniel R. Ripoll, Lesley C. Dupuy, Anders Wallqvist, Connie S. Schmaljohn, Daniel A. J. Mitchell, Sidhartha Chaudhury
Publikováno v:
Human Vaccines & Immunotherapeutics
Ebola virus (EBOV) infection is highly lethal and results in severe febrile bleeding disorders that affect humans and non-human primates. One of the therapeutic approaches for treating EBOV infection focus largely on cocktails of monoclonal antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d48d6c3e75f5b32b2fa01d51bdb86e2
https://doi.org/10.1080/21645515.2017.1360454
https://doi.org/10.1080/21645515.2017.1360454
Autor:
Sidhartha Chaudhury, Daniel R. Ripoll, Connie S. Schmaljohn, Mariano Sanchez-Lockhart, Katya Shimanovskaya, Anders Wallqvist, Daniel A. J. Mitchell, Jaap W. Back, Lesley C. Dupuy, Gustavo Palacios
Publikováno v:
Human Vaccines & Immunotherapeutics
We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934469149c45ab924c7758da5f2497b2
https://doi.org/10.1080/21645515.2017.1347740
https://doi.org/10.1080/21645515.2017.1347740
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
Recent clinical studies have revealed that severe symptoms of dengue fever are associated with low pre-existing antibody levels. These findings provide direct clinical evidence for the theory of antibody-dependent enhancement of infection (ADE), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df170af09456573299430261b24dd9b
https://www.frontiersin.org/article/10.3389/fcimb.2019.00200/full
https://www.frontiersin.org/article/10.3389/fcimb.2019.00200/full
Publikováno v:
Biochemistry and Biophysics Reports
pH-induced conformational changes in dengue virus (DENV) are critical to its ability to infect host cells. The envelope protein heterodimers that make up the viral envelope shift from a dimer to a trimer conformation at low-pH during membrane fusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bf425fd88ee2139d43e77aa8ac1d04
Autor:
Ilja V. Khavrutskii, Sidhartha Chaudhury, Anders Wallqvist, Daniel R. Ripoll, Gregory D. Gromowski, Valmik Desai
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
Background A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234bee0ee5a37e3b3ff2ae50be88c8bf
http://europepmc.org/articles/PMC5336305
http://europepmc.org/articles/PMC5336305