Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Daniel R Ram"'
Autor:
Sho Sugawara, Brady Hueber, Griffin Woolley, Karen Terry, Kyle Kroll, Cordelia Manickam, Daniel R Ram, Lishomwa C Ndhlovu, Paul Goepfert, Stephanie Jost, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011629 (2023)
Despite their importance, natural killer (NK) cell responses are frequently dysfunctional during human immunodeficiency virus-1 (HIV-1) and simian immunodeficiency virus (SIV) infections, even irrespective of antiretroviral therapies, with poorly und
Externí odkaz:
https://doaj.org/article/d835155fe136473c8794b99be669f303
Autor:
Daniel R Ram, Cordelia Manickam, Brady Hueber, Hannah L Itell, Sallie R Permar, Valerie Varner, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007104 (2018)
Natural killer (NK) cells classically typify the nonspecific effector arm of the innate immune system, but have recently been shown to possess memory-like properties against multiple viral infections, most notably CMV. Expression of the activating re
Externí odkaz:
https://doaj.org/article/72400d5802f548209f7947e7e83fb184
Autor:
Rhianna Jones, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, Daniel R. Ram, Cordelia Manickam, Valerie Varner, Nichole R. Klatt, R. Keith Reeves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of
Externí odkaz:
https://doaj.org/article/48692deb9b0a4041ad526778e7eb2847
Autor:
Spandan V. Shah, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, R. Keith Reeves
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2766-2774.e3 (2018)
Summary: Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain
Externí odkaz:
https://doaj.org/article/b1b79024dacf4c05b753314b715b4331
Publikováno v:
Journal of Leukocyte Biology. 105:1253-1259
NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency virus (SIV)-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae83bcf2621de0984a7555a08778bc2b
https://doi.org/10.1002/jlb.mr0718-303r
https://doi.org/10.1002/jlb.mr0718-303r
Autor:
Scott Smith, Rhianna Jones, Kyle Kroll, Daniel R. Ram, Spandan V. Shah, Griffin Woolley, Cordelia Manickam, R. Keith Reeves, Valerie Varner, Brady Hueber
Publikováno v:
Immunology
Granulocytes mediate broad immunoprotection through phagocytosis, extracellular traps, release of cytotoxic granules, antibody effector functions and recruitment of other immune cells against pathogens. However, descriptions of granulocytes in HIV in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb2f58bf1225501b03594f5928394ab
https://europepmc.org/articles/PMC8442246/
https://europepmc.org/articles/PMC8442246/
Autor:
Kyle Kroll, Rhianna Jones, Griffin Woolley, Spandan V. Shah, Scott Smith, Cordelia Manickam, R. Keith Reeves, Brady Hueber, Daniel R. Ram, Valerie Varner
Granulocytes mediate broad immunoprotection through phagocytosis, extracellular traps, release of cytotoxic granules, antibody effector functions and recruitment of other immune cells against pathogens. However, descriptions of granulocytes in HIV in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aad2b3de7c659ff06d8995faf7ede00
https://doi.org/10.1101/2021.03.19.436235
https://doi.org/10.1101/2021.03.19.436235
Autor:
Daniel R. Ram, Courtney Broedlow, Brady Hueber, Nichole R. Klatt, Luca Schifanella, Cordelia Manickam, Spandan V. Shah, Scott Smith, Rhianna Jones, R. Keith Reeves, Valerie Varner, Kyle Kroll
HIV/SIV infections lead to massive loss of mucosal CD4+ T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of one of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e145b2a33db6110501e9a382459636ca
https://doi.org/10.1101/2020.12.17.423321
https://doi.org/10.1101/2020.12.17.423321
Publikováno v:
AIDS Res Hum Retroviruses
Natural killer (NK) cells provide some of the earliest immune responses to infection, but when viruses manipulate or perturb the immune environment to alter NK cell function, this places the host at a disadvantage. Indeed, others and we observe that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaaf4490fc150bd2050646186d35791
https://pubmed.ncbi.nlm.nih.gov/32862656
https://pubmed.ncbi.nlm.nih.gov/32862656
Autor:
Rhianna Jones, Scott Smith, Christian F. Arias, Cordelia Manickam, R. Keith Reeves, Valerie Varner, Spandan V. Shah, Brady Hueber, Daniel R. Ram, Kyle Kroll
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
CD49a+ tissue resident NK cells have been implicated in memory-like NK cell responses, but while this population is well-characterized in mice and in humans, they are poorly described in non-human primates (NHP) which are particularly critical for mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6688ffe7fcbe1816fc072baa969ad9
http://europepmc.org/articles/PMC7411078
http://europepmc.org/articles/PMC7411078