Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Daniel R Ambruso"'
In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.
Autor:
Daniel R Ambruso, Natalie J Briones, Angelina F Baroffio, John R Murphy, Alexander D Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L Jones
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Externí odkaz:
https://doaj.org/article/5560076a792640a2978e1586fa78271e
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185956 (2017)
The cytokine interferon-γ (IFN-γ) is approved as a drug to treat chronic granulomatous disease (CGD) and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. Patients with CGD have defects in proteins of the NOX2 NADPH oxidase system.
Externí odkaz:
https://doaj.org/article/9c8634d52e5d460c8b01fdb7b668e9ca
Autor:
Michael A Ellison, Gail Thurman, Christy M Gearheart, Ryan H Seewald, Christopher C Porter, Daniel R Ambruso
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136766 (2015)
The cytokine and drug interferon-γ enhances superoxide anion production by the antimicrobicidal Nox2 enzyme of neutrophils. Because mature neutrophils have a short lifespan, we hypothesized that the effects of interferon-γ on these cells might be m
Externí odkaz:
https://doaj.org/article/c1cdf1774eb34aecacbf1fedc0e619cb
Autor:
Susan Harvey, Kristine Wolter‐Warmerdam, Francis Hickey, Dee Daniels, Melkon DomBourian, Daniel R. Ambruso, Christopher McKinney
Publikováno v:
Pediatric Blood & Cancer. 69
Children with Down syndrome (DS) are more likely to have hematologic and immunologic abnormalities compared to their typically developing peers, but normal ranges have not been defined. The goal of this study was to create references for complete blo
Autor:
John Murphy, Daniel R. Ambruso, Angelina Baroffio, Alexander D. Tran, Michael Ellison, Julie A. Reisz, Christopher M. McKinney, Natalie J. Briones, Angelo D'Alessandro
Publikováno v:
Blood Adv
Severe congenital neutropenia type 4 (SCN-4) is an autosomal recessive condition in which mutations in the G6PC3 gene encoding for the catalytic 3 subunit of glucose-6-phosphatase-β result in neutropenia, neutrophil dysfunction, and other syndromic
Autor:
Robin Abel, Steven H. Abman, Eric Alton, Daniel R. Ambruso, William Carl Anderson, Karthik Balakrishnan, Ian Michael Balfour-Lynn, Anna Bamford, Ronen Bar-Yoseph, Erika Berman-Rosenzweig, Deepika Bhatla, Joshua A. Blatter, R. Paul Boesch, Matias Bruzoni, Andrew Bush, Michael Bye, Kai Håkon Carlsen, Anne B. Chang, Stephanie D. Chao, Michelle Chatwin, Bimal Pankaj Chaudhari, Lyn Chitty, Nicola Collins, Dan M. Cooper, Jonathan Corren, Robin T. Cotton, Andrea Coverstone, Suzanne Crowley, Steve Cunningham, Garry R. Cutting, Dorottya Czovek, Charles L. Daley, Gwyneth Davies, Jane C. Davies, Alessandro de Alarcòn, Emily M. DeBoer, Marietta Morales De Guzman, Sharon D. Dell, Robin Deterding, Gail H. Deutsch, Sunalene Devadason, William Graham Fox Ditcham, Jill Dorsey, Francine M. Ducharme, John Engelhardt, Mark L. Everard, Leland L. Fan, Albert Faro, Thomas Ferkol, Louise Fleming, Angela Mary Fonceca, Hammad A. Ganatra, Amy Michelle Garcia, David Gozal, Diane Gray, Anne Greenough, Uta Griesenbach, Jonathan Grigg, James S. Hagood, Jürg Hammer, Aaron Hamvas, Jonny Harcourt, Pia J. Hauk, Ulrich Heininger, Alexander John Henderson, Marianna M. Henry, Richard J. Hewitt, Heather Young Highsmith, Noah H. Hillman, Heather Ellen Hoch, Jeong S. Hyun, Mas Suhaila Isa, Adam Jaffé, Lance C. Jennings, Alan H. Jobe, Ankur A. Kamdar, Bhushan Katira, Brian P. Kavanagh, James Kemp, Carolyn M. Kercsmar, Leila Kheirandish-Gozal, Wilson King, Paul Kingma, Jennifer Knight-Madden, Alan Paul Knutsen, Alik Kornecki, Usha Krishnan, Geoffrey Kurland, Hugh Simon Lam, Claire Langston, Ada Lee, Margaret W. Leigh, Daniel Lesser, Clare M. Lloyd, Anna Maria Mandalakas, Paulo J.C. Marostica, Stacey L. Martiniano, Jennifer Maybee, Karen M. McDowell, Peter Michelson, Aaron Samuel Miller, Claire Kane Miller, Ayesha Mirza, David R. Murdoch, Christopher J.L. Newth, Andrew Gordon Nicholson, Jerry A. Nick, Christina J. Nicolais, Terry L. Noah, Lawrence M. Nogee, Blakeslee Noyes, Andrew H. Numa, Ann-Christine Nyquist, Hugh O'Brodovich, Matthias Ochs, J. Tod Olin, Øystein Olsen, Catherine Owens, Howard B. Panitch, Hans Pasterkamp, Donald Payne, Scott Pentiuk, Jeremy Prager, Jean-Paul Praud, Andrew P. Prayle, Bernadette Prentice, Philip E. Putnam, Alexandra L. Quittner, Shlomit Radom-Aizik, Suchitra Rao, Mobeen Rathore, Gregory J. Redding, Michael Rutter, Estefany Saez-Flores, Sejal Saglani, Rayfel Schneider, Kenneth O. Schowengerdt, Marcelo C. Scotta, Thomas Semple, Laurie Sherlock, Ram N. Singh, Raymond G. Slavin, Peter Sly, Bjarne Smevik, Keely Garrett Smith, Jonathan Spahr, James M. Stark, Jeffrey R. Starke, Renato T. Stein, Paul C. Stillwell, Dennis C. Stokes, Daniel T. Swarr, Stuart Charles Sweet, Stanley James Szefler, Paul Tambyah, Christelle Xian-Ting Tan, James Temprano, Chad M. Thorson, Bruce C. Trapnell, Brian Michael Varisco, Timothy J. Vece, Harish G. Vyas, Ruth Wakeman, Colin Wallis, Jennifer Wambach, Daniel J. Weiner, Anja M. Werno, Susan E. Wert, Jeffrey A. Whitsett, Robert William Wilmott, Robert E. Wood, Christopher Todd Wootten, Marie Wright, Sarah Wright, Rae S.M. Yeung, Takeshi Yoshida, Carolyn Young, Lisa R. Young, Heather J. Zar, Pamela Leslie Zeitlin, David Zielinski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d96ab4068e695d68baf2fc1b6f5cab
https://doi.org/10.1016/b978-0-323-44887-1.00085-7
https://doi.org/10.1016/b978-0-323-44887-1.00085-7
Autor:
Pia J. Hauk, Daniel R. Ambruso
Publikováno v:
Kendig's Disorders of the Respiratory Tract in Children ISBN: 9780323448871
Primary immunodeficiency states are not uncommon disorders which can affect the innate or adaptive arms of the immune system. All of these diseases have the potential for adverse pulmonary manifestations, including infections and noninfectious compli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1609343cf7393d88345c0ffa8aa4368b
https://doi.org/10.1016/b978-0-323-44887-1.00063-8
https://doi.org/10.1016/b978-0-323-44887-1.00063-8
Autor:
Jaeyul Kwon, Ilker Ersoy, Ryuichi Sugamata, Thomas L. Leto, Liang Yi, Yongsoo Kim, Agnieszka Korzeniowska, Aibing Wang, Devin J. Burke, Daniel R. Ambruso, Kristen Lekstrom, Stefan Jaeger, Sharon H. Jackson, Kannappan Palaniappan, Howard E. Boudreau
Publikováno v:
Free Radical Biology and Medicine. 96:99-115
Nox1 is an abundant source of reactive oxygen species (ROS) in colon epithelium recently shown to function in wound healing and epithelial homeostasis. We identified Peroxiredoxin 6 (Prdx6) as a novel binding partner of Nox activator 1 (Noxa1) in yea
Autor:
Lawrence D. Petz, Mary J. Laughlin, Joseph E. Kiss, Sue Armitage, Leonard S. Sender, Rachel L. Beddard, Kathleen Sazama, John R. Wingard, Ralph Quinones, Millicent Sutton, William Hwang, Arnon Nagler, Mary Eapen, Daniel R. Ambruso, Deepika Bhatla, Gesine Koegler, Andromachi Scaradavou, Wensheng He, Karen K. Ballen, Stephen R. Spellman, Elizabeth J. Shpall, Thomas H. Price, Brent R. Logan, Joanne Kurtzberg, Voravit Ratanatharathorn, J. Douglas Rizzo, Michael W. Schuster, Lee Ann Weitekamp, David Oh
Publikováno v:
Biology of Blood and Marrow Transplantation. 21:688-695
Variations in cord blood manufacturing and administration are common, and the optimal practice is not known. We compared processing and banking practices at 16 public cord blood banks (CBB) in the United States and assessed transplantation outcomes o
Autor:
Anand Padmanabhan, D. Nicole Worsham, Jerry Bill, Susan L. Pinkard, Sharon Graminske, Jose A. Cancelas, Julie Goldberg, Tuan Le, Daniel R. Ambruso, Jennifer Buck, Neeta Rugg
Publikováno v:
Transfusion. 55:748-755
Background Granulocyte transfusion from healthy donors is used in the treatment of patients with granulocyte function defects, or transient neutropenia and severe bacterial or fungal infections resistant to maximal antimicrobial treatment. Study Desi