Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Daniel R Altmann"'
Autor:
Marios C Yiannakas, Francesco Grussu, Polymnia Louka, Ferran Prados, Rebecca S Samson, Marco Battiston, Daniel R Altmann, Sebastien Ourselin, David H Miller, Claudia A M Gandini Wheeler-Kingshott
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164890 (2016)
Diffusion tensor imaging (DTI) has recently started to be adopted into clinical investigations of spinal cord (SC) diseases. However, DTI applications to the lower SC are limited due to a number of technical challenges, related mainly to the even sma
Externí odkaz:
https://doaj.org/article/9232cd7d6ad6458fac23686898e1deff
Autor:
Khaled Abdel-Aziz, Bhavana S Solanky, Marios C Yiannakas, Daniel R Altmann, Claudia A M Wheeler-Kingshott, Alan J Thompson, Olga Ciccarelli
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e105774 (2014)
Magnetic resonance spectroscopy (MRS) studies have previously described metabolite changes associated with aging of the healthy brain and provided insights into normal brain aging that can assist us in differentiating age-related changes from those a
Externí odkaz:
https://doaj.org/article/45dfd4784dea45ad975fbdab7d498968
Autor:
J. William L. Brown, Ferran Prados, Daniel R. Altmann, Baris Kanber, Jonathan Stutters, Nick G. Cunniffe, Joanne L. Jones, Zoya G. Georgieva, Edward J. Needham, Cyrus Daruwalla, Claudia Gandini Wheeler‐Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 10, Pp 1626-1642 (2022)
Abstract Objective In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexa
Externí odkaz:
https://doaj.org/article/1826f850492946098c69aca992564af5
Autor:
Charles ffrench-Constant, David G. MacManus, Jonathan Stutters, Owen R Pearson, DT Chard, Baris Kanber, Edward Needham, Zoya Georgieva, Joanne L. Jones, David Rog, Alasdair Coles, Rebecca S. Samson, Claudia A. M. Wheeler-Kingshott, J William L Brown, Ferran Prados, Peter Connick, Andrew W. Michell, Siddharthan Chandran, James Overell, Daniel R. Altmann, Paul D Flynn, Robin J.M. Franklin, Nick G Cunniffe, Carla Moran
Publikováno v:
Brown, J W L, Cunniffe, N G, Prados, F, Kanber, B, Jones, J L, Needham, E, Georgieva, Z, Rog, D, Pearson, O R, Overell, J, Macmanus, D, Samson, R S, Stutters, J, Ffrench-constant, C, Gandini Wheeler-kingshott, C A M, Moran, C, Flynn, P D, Michell, A W, Franklin, R J M, Chandran, S, Altmann, D R, Chard, D T, Connick, P & Coles, A J 2021, ' Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study ', The Lancet Neurology, vol. 20, no. 9, pp. 709-720 . https://doi.org/10.1016/S1474-4422(21)00179-4
Summary Background Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d23ac9c1ac3d67ed9a8f869f9bb4d7
https://doi.org/10.1016/s1474-4422(21)00179-4
https://doi.org/10.1016/s1474-4422(21)00179-4
Autor:
Gilbert Thomas‐Black, Daniel R. Altmann, Harry Crook, Nita Solanky, Ferran Prados Carrasco, Marco Battiston, Francesco Grussu, Marios C. Yiannakas, Baris Kanber, Jasleen K. Jolly, Jon Brett, Susan M. Downes, Marni Moran, Ping K. Chan, Emmanuel Adewunmi, Claudia A.M. Gandini Wheeler‐Kingshott, Andrea H. Németh, Richard Festenstein, Fion Bremner, Paola Giunti
Optic neuropathy is a near ubiquitous feature of Friedreich's ataxia (FRDA). Previous studies have examined varying aspects of the anterior and posterior visual pathways but none so far have comprehensively evaluated the heterogeneity of degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f811871f92d3a5ab2b82398c806fc962
http://hdl.handle.net/10044/1/103490
http://hdl.handle.net/10044/1/103490
Autor:
Sharmilee Gnanapavan, Daniel R. Altmann, Henrik Zetterberg, Jens Kuhle, Gavin Giovannoni, Rhian Raftopoulos, Simon J. Hickman, David Leppert, Donna Grant, Kaj Blennow, Raj Kapoor
Publikováno v:
European Journal of Neurology. 28:587-594
Background A randomized trial of phenytoin in acute optic neuritis (ON) demonstrated a 30% reduction in retinal nerve fiber layer (RNFL) loss with phenytoin versus placebo. Here we present the corresponding serum neurofilament analyses. Methods Eight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbbe9cfb59ae4df5ec05f9116c4156f
https://doi.org/10.1111/ene.14591
https://doi.org/10.1111/ene.14591
Autor:
Claudia A. M. Wheeler-Kingshott, Wallace J Brownlee, Frederik Barkhof, Olga Ciccarelli, Daniel R. Altmann, Arman Eshaghi, KA Miszkiel, Ferran Prados
Publikováno v:
Brain, 142(8), 2276-2287. Oxford University Press
Brownlee, W J, Altmann, D R, Prados, F, Miszkiel, K A, Eshaghi, A, Gandini Wheeler-Kingshott, C A M, Barkhof, F & Ciccarelli, O 2019, ' Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis ', Brain, vol. 142, no. 8, pp. 2276-2287 . https://doi.org/10.1093/brain/awz156
Brownlee, W J, Altmann, D R, Prados, F, Miszkiel, K A, Eshaghi, A, Gandini Wheeler-Kingshott, C A M, Barkhof, F & Ciccarelli, O 2019, ' Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis ', Brain, vol. 142, no. 8, pp. 2276-2287 . https://doi.org/10.1093/brain/awz156
The clinical course of relapse-onset multiple sclerosis is highly variable. Demographic factors, clinical features and global brain T2 lesion load have limited value in counselling individual patients. We investigated early MRI predictors of key long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9947130d286a681b566c74373b1123c2
https://doi.org/10.1093/brain/awz156
https://doi.org/10.1093/brain/awz156
Publikováno v:
Brain Pathology. 28:334-348
Preventing chronic disease deterioration is an unmet need in people with multiple sclerosis, where axonal loss is considered a key substrate of disability. Clinically, chronic multiple sclerosis often presents as progressive myelopathy. Spinal cord c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e2c6bbefee3a51d392f0687ef7cd93
https://doi.org/10.1111/bpa.12516
https://doi.org/10.1111/bpa.12516
Autor:
Erik Nutma, Daniele Carassiti, Daniel R. Altmann, James Rs Newman, N Petrova, David Baker, Sandra Amor, Klaus Schmierer
Publikováno v:
Annals of Neurology, 88(3), 619-625. John Wiley and Sons Inc.
Petrova, N, Nutma, E, Carassiti, D, Rs Newman, J, Amor, S, Altmann, D R, Baker, D & Schmierer, K 2020, ' Synaptic Loss in Multiple Sclerosis Spinal Cord ', Annals of Neurology, vol. 88, no. 3, pp. 619-625 . https://doi.org/10.1002/ana.25835
Petrova, N, Nutma, E, Carassiti, D, Rs Newman, J, Amor, S, Altmann, D R, Baker, D & Schmierer, K 2020, ' Synaptic Loss in Multiple Sclerosis Spinal Cord ', Annals of Neurology, vol. 88, no. 3, pp. 619-625 . https://doi.org/10.1002/ana.25835
Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area—a predictor of disability—is poor, questioning the unique role of axonal loss. We investigated the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95b56e9aa75f780fe194faf235e6e45
https://pubmed.ncbi.nlm.nih.gov/32608018
https://pubmed.ncbi.nlm.nih.gov/32608018
Autor:
Niamh Cawley, Ferran Prados, Olga Ciccarelli, Jonathan D. Clayden, Carmen Tur, Daniel R. Altmann, Francesco Grussu, Frederik Barkhof, Thalis Charalambous, Baris Kanber, Sebastien Ourselin, Sara Collorone, Ahmed T. Toosy, Claudia Am Gandini Wheeler-Kingshott
Publikováno v:
Mult Scler
Tur, C, Grussu, F, Prados, F, Charalambous, T, Collorone, S, Kanber, B, Cawley, N, Altmann, D R, Ourselin, S B, Barkhof, F, Clayden, J D, Toosy, A T, Wheeler-Kingshott, C A M G & Ciccarelli, O 2020, ' A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis ', Multiple Sclerosis Journal, vol. 26, no. 7, pp. 774-785 . https://doi.org/10.1177/1352458519845105
Multiple Sclerosis Journal, 26(7), 774-785. SAGE Publications Ltd
Multiple Sclerosis Journal
Tur, C, Grussu, F, Prados, F, Charalambous, T, Collorone, S, Kanber, B, Cawley, N, Altmann, D R, Ourselin, S B, Barkhof, F, Clayden, J D, Toosy, A T, Wheeler-Kingshott, C A M G & Ciccarelli, O 2020, ' A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis ', Multiple Sclerosis Journal, vol. 26, no. 7, pp. 774-785 . https://doi.org/10.1177/1352458519845105
Multiple Sclerosis Journal, 26(7), 774-785. SAGE Publications Ltd
Multiple Sclerosis Journal
Background: The potential of multi-shell diffusion imaging to produce accurate brain connectivity metrics able to unravel key pathophysiological processes in multiple sclerosis (MS) has scarcely been investigated. Objective: To test, in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6fdeb8bb7a9440070e1c6f0a4b54f1
https://europepmc.org/articles/PMC7611366/
https://europepmc.org/articles/PMC7611366/