Výsledky vyhledávání - "Daniel Pulliam"

Akademický článek

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

Autor: Gavin Pharaoh, Daniel Pulliam, Shauna Hill, Kavithalakshmi Sataranatarajan, Holly Van Remmen

Publikováno v: Redox Biology, Vol 8, Iss C, Pp 430-438 (2016)

Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UP

Externí odkaz: https://doaj.org/article/aa2fc58866764184added2e583834ed6

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Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle

Autor: Daniel Pulliam, Arunabh Bhattacharya, Yuhong Liu, Adam B. Salmon

Publikováno v: Aging pathobiology and therapeutics

Objective: Mitochondrial dysfunction comprises part of the etiology of myriad health issues, particularly those that occur with advancing age. Methionine sulfoxide reductase A (MsrA) is a ubiquitous protein oxidation repair enzyme that specifically a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7093c9328d4c78938bc8fd03a5c8e94
http://europepmc.org/articles/PMC8023689

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Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

Autor: Shauna Hill, Gavin Pharaoh, Holly Van Remmen, Kavithalakshmi Sataranatarajan, Daniel Pulliam

Publikováno v: Redox Biology
Redox Biology, Vol 8, Iss C, Pp 430-438 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ededc21964cbaf7ad78560fe0a3e057

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Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

Autor: Michael Kinter, Daniel Pulliam, Arlan Richardson, Kaitlyn Riddle, Wilson C. Fok, Gavin Pharaoh, Holly Van Remmen, Vanessa Y. Soto, Shauna Hill, Jonathan D. Wren, Sathyaseelan S. Deepa, Vivian Diaz, Carlo Viscomi, Constantin Georgescu, Kathleen E. Fischer

Publikováno v: Aging Cell

Summary Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes in metabolism (reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d1966da85be4d1e958eb572e6f219
http://hdl.handle.net/11577/3321362

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Complex IV-deficient Surf1−/− mice initiate mitochondrial stress responses

Autor: Lauren B. Sloane, Shauna Hill, Holly Van Remmen, Yuhong Liu, Ai-Ling Lin, Arunabh Bhattacharya, Yun Shi, Carlo Viscomi, Sathyaseelan S. Deepa, Daniel Pulliam, Massimo Zeviani

Publikováno v: Biochemical Journal. 462:359-371

Mutations in SURF1 (surfeit locus protein 1) COX (cytochrome c oxidase) assembly protein are associated with Leigh's syndrome, a human mitochondrial disorder that manifests as severe mitochondrial phenotypes and early lethality. In contrast, mice lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a68955892abe34023be3604709c478
https://doi.org/10.1042/bj20140291

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Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice

Autor: Stacy A. Hussong, Jonathan J. Halloran, Sathyaseelan S. Deepa, Massimo Zeviani, Arlan Richardson, Andrew Bresnen, Anuradha Soundararajan, Veronica Galvan, Timothy Q. Duong, Holly Van Remmen, Yuhong Liu, Ai-Ling Lin, Peter T. Fox, Alex Bokov, Carlo Viscomi, Daniel Pulliam, Eric R. Muir, Natalia Podlutskaya, Raquel R. Burbank

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 33:1605-1611

Recent studies have challenged the prevailing view that reduced mitochondrial function and increased oxidative stress are correlated with reduced longevity. Mice carrying a homozygous knockout (KO) of the Surf1 gene showed a significant decrease in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c729bd5a7be1fdbe8c3d5d822a11775e
https://doi.org/10.1038/jcbfm.2013.116

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CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Autor: George K. Sakellariou, Arunabh Bhattacharya, Arlan Richardson, Yiqiang Zhang, Holly Van Remmen, Malcolm J. Jackson, Daniel Pulliam, Anne McArdle, Carol S. Davis, Anna C. Kayani, Susan V. Brooks, Yun Shi

Publikováno v: The FASEB Journal. 27:3536-3548

We have previously shown that deletion of CuZnSOD in mice (Sod1−/− mice) leads to accelerated loss of muscle mass and contractile force during aging. To dissect the relative roles of skeletal muscle and motor neurons in this process, we used a Cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaaa7e126705097ee62022f82e65329
https://doi.org/10.1096/fj.13-228130

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Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

Autor: Yun Shi, Sathyaseelan S. Deepa, Holly Van Remmen, Adam B. Salmon, Ning Zhang, Daniel Pulliam, Michael E. Walsh, Nicolas Musi, Carlo Viscomi, Shauna Hill, Lauren B. Sloane, Massimo Zeviani

Publikováno v: The FASEB Journal. 27:1371-1380

Mice lacking Surf1, a complex IV assembly protein, have ∼50-70% reduction in cytochrome c oxidase activity in all tissues yet a paradoxical increase in lifespan. Here we report that Surf1(-/-) mice have lower body (15%) and fat (20%) mass, in assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5975e99d26e2503a6c0caac25a45e7
https://doi.org/10.1096/fj.12-221879

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Sco2 deficient mice develop increased adiposity and insulin resistance

Autor: Yuhong Liu, Holly Van Remmen, Shauna Hill, Pavithra Premkumar, Sathyaseelan S. Deepa, Vanessa Y. Soto, Kavithalakshmi Sataranatarajan, Daniel Pulliam, Kathleen E. Fischer

Publikováno v: Molecular and cellular endocrinology. 455

Cytochrome c oxidase (COX) is an essential transmembrane protein complex (Complex IV) in the mitochondrial respiratory electron chain. Mutations in genes responsible for the assembly of COX are associated with Leigh syndrome, cardiomyopathy, spinal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec48616ffaf42fb9447b0ed39ec1405b
https://pubmed.ncbi.nlm.nih.gov/28428045

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