Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Daniel Prantner"'
Autor:
Alexandra M. Vlk, Daniel Prantner, Kari Ann Shirey, Darren J. Perkins, Marguerite S. Buzza, Vivek Thumbigere-Math, Achsah D. Keegan, Stefanie N. Vogel
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Toll-like receptor 4 (TLR4) is an innate immune receptor responsive to lipopolysaccharide (LPS). Single nucleotide polymorphisms (SNPs) in human TLR4 that encode an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4
Externí odkaz:
https://doaj.org/article/f82f77beb83c4333bc1d7309aed50634
Publikováno v:
FASEB J
Although the innate immune receptor protein, Receptor for Advanced Glycation End products (RAGE), has been extensively studied, there has been renewed interest in RAGE for its potential role in sepsis, along with a host of other inflammatory diseases
Autor:
Daniel Prantner, Stefanie N. Vogel, David Spiegel, Katharina Richard, Shreeram C. Nallar, Kim D. Collins
Publikováno v:
J Leukoc Biol
The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and tissues by reacting with cellular macromolecules. MG has been identified as a biomarker associated with increased sepsis-induced mortality. Patients undergoing septi
Autor:
Rachel Fanaroff, Alexandra Vlk, Kari Ann Shirey, W.Y.C. Lai, Darren J. Perkins, Chiguang Feng, Shreeram C. Nallar, Stefanie N. Vogel, Vladimir Y. Toshchakov, Andrei E. Medvedev, Kurt H. Piepenbrink, Katharina Richard, Daniel Prantner, Jorge C. G. Blanco, Archana Gopalakrishnan
Publikováno v:
The Journal of Experimental Medicine
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS
Autor:
Daniel Prantner, W.Y.C. Lai, Alfredo Garzino-Demo, Wuyuan Lu, Stefanie N. Vogel, Alexander M. Cole, Kari Ann Shirey
Publikováno v:
Journal of Leukocyte Biology
Despite widespread use of annual influenza vaccines, seasonal influenza-associated deaths number in the thousands each year, in part because of exacerbating bacterial superinfections. Therefore, discovering additional therapeutic options would be a v
The host protein Stimulator of Interferon Genes (STING) has been shown to be essential for recognition of both viral and intracellular bacterial pathogens, but its regulation remains unclear. Previously, we reported that mitochondrial membrane potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fbc61f9cef25192d39d0d6e8b41bda
https://europepmc.org/articles/PMC5217687/
https://europepmc.org/articles/PMC5217687/
Autor:
Uma M. Nagarajan, Margaret Mintus, Tammy E. Tomasak, Toni Darville, Jeanne E. Sullivan, Matthew A. Zurenski, Lauren C. Frazer, Daniel Prantner
Publikováno v:
The Journal of Immunology. 191:4269-4279
Resolution of Chlamydia genital tract infection is delayed in the absence of MyD88. In these studies, we first used bone marrow chimeras to demonstrate a requirement for MyD88 expression by hematopoietic cells in the presence of a wild-type epitheliu
Publikováno v:
The Journal of Immunology. 188:2866-2875
IL-1β has been implicated in the development of oviduct pathology during Chlamydia muridarum genital infection in the mouse model. The goal of this study was to characterize the role of IL-1 signaling and the inflammasome-activation pathways during
Autor:
Anna Goodwin, James D. Sikes, Uma M. Nagarajan, Daniel Prantner, Toni Darville, Jessica N. Snowden, Charles W. Andrews, Lauren C. Frazer
Publikováno v:
Infection and Immunity. 79:486-498
We have previously shown that MyD88 knockout (KO) mice exhibit delayed clearance of Chlamydia muridarum genital infection compared to wild-type (WT) mice. A blunted Th1 response and ineffective suppression of the Th2 response were also observed in My
Autor:
Anna M. Goodwin, Toni Darville, Shanmugam Nagarajan, James D. Sikes, Daniel Prantner, Charles W. Andrews, Uma M. Nagarajan
Publikováno v:
Infection and Immunity. 76:4642-4648
Type I interferons (IFNs) induced during in vitro chlamydial infection exert bactericidal and immunomodulatory functions. To determine the precise role of type I IFNs during in vivo chlamydial genital infection, we examined the course and outcome of