Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Daniel Poeckel"'
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibr
Externí odkaz:
https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Autor:
Toby Mathieson, Holger Franken, Jan Kosinski, Nils Kurzawa, Nico Zinn, Gavain Sweetman, Daniel Poeckel, Vikram S. Ratnu, Maike Schramm, Isabelle Becher, Michael Steidel, Kyung-Min Noh, Giovanna Bergamini, Martin Beck, Marcus Bantscheff, Mikhail M. Savitski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The proteome-wide characterization of proteostasis depends on robust approaches to determine protein half-lives. Here, the authors improve the accuracy and precision of mass spectrometry-based quantification, enabling reliable protein half-life deter
Externí odkaz:
https://doaj.org/article/da0726d0c6b44f4fa437f686bacfcd20
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/35a6295d2586420286eccc316b713105
Autor:
Keith R. Brunt, Jun Wu, Zhilin Chen, Daniel Poeckel, Ryan A. Dercho, Luis G. Melo, Colin D. Funk, Christopher A. Ward, Ren-Ke Li
Publikováno v:
Cell Transplantation, Vol 21 (2012)
The aim of this study was to evaluate the overexpression of genes central to cell survival and angiogenesis to enhance the function of human late outgrowth endothelial progenitor cells (EPCs) and their utility for infarct recovery. Ischemic myocardia
Externí odkaz:
https://doaj.org/article/a5b934dcbe354639a0702f0eca7d5263
Autor:
Jessica Perrin, Frank Wippich, Valeriia Sherina, Dmytro Dvornikov, Katharina Lupar, Murad M. Melhem, Patrick Hanafin, Jeremy Waight, Jong Yu, Sapna Yadavilli, Daniel Poeckel, Giovanna Bergamini
Publikováno v:
Cancer Research. 83:6647-6647
The ability to more faithfully mimic the tumor microenvironment (TME) of cancer patients offers a wide range of possibilities for non-clinical evaluation of anti-cancer therapeutics, including guidance for patient selection, dose, and combinations. W
Autor:
Dmytro Dvornikov, Aliaksandr Halavatyi, Muzamil Majid Khan, Natalie Zimmermann, Amy Cross, Daniel Poeckel, Emil Melnikov, Christian Tischer, Johannes Leyrer, Marc A Schneider, Thomas Muley, Hauke Winter, Edith Hessel, Soren Beinke, Rainer Pepperkok
Chronic obstructive pulmonary disease (COPD) is one of the major causes of disability and death worldwide and a significant risk factor for respiratory infections. Rhinoviral infections are the most common trigger of COPD exacerbations which lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca6c7373b80ce7f91c0f6601e05f3bf7
https://doi.org/10.1101/2022.03.01.482451
https://doi.org/10.1101/2022.03.01.482451
Autor:
Nils Kurzawa, Marcus Bantscheff, Mikhail M. Savitski, Eugenia Stonehouse, Maria Faelth-Savitski, Holger Franken, Bianca Heller, Christina Rau, Jessica Perrin, Anna Rutkowska, H. Christian Eberl, Johanna Vappiani, Daniel C. Sévin, Isabelle Becher, Katrin Strohmer, Jana Krause, Thilo Werner, Douglas W. Thomson, Wolfgang Huber, Daniel Poeckel, Giovanna Bergamini, Mathias Kalxdorf, Dorothee Childs
Publikováno v:
Nature Biotechnology. 38:303-308
Monitoring drug-target interactions with methods such as the cellular thermal-shift assay (CETSA) is well established for simple cell systems but remains challenging in vivo. Here we introduce tissue thermal proteome profiling (tissue-TPP), which mea
Autor:
Marcus Bantscheff, Daniel Poeckel, Ramanjulu Joshi M, Jessica Perrin, Christina Rau, Katrin Strohmer, Birgit Duempelfeld, Nico Zinn, G. Scott Pesiridis, Giovanna Bergamini, Marcel Muelbaier, Douglas W. Thomson, Anne J. Wagner, Viera Kasparcova, Alan P. Graves
Publikováno v:
ACS Med Chem Lett
[Image: see text] The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and n
Autor:
Muzamil Majid, Khan, Daniel, Poeckel, Aliaksandr, Halavatyi, Joanna, Zukowska-Kasprzyk, Frank, Stein, Johanna, Vappiani, Daniel C, Sevin, Christian, Tischer, Nico, Zinn, Jessica D, Eley, Natasja Stæhr, Gudmann, Thomas, Muley, Hauke, Winter, Andrew J, Fisher, Carmel B, Nanthakumar, Giovanna, Bergamini, Rainer, Pepperkok
Publikováno v:
The European respiratory journal. 58(1)
Fibrosis can affect any organ, resulting in the loss of tissue architecture and function with often life-threatening consequences. Pathologically, fibrosis is characterised by the expansion of connective tissue due to excessive deposition of extracel
Autor:
Aliaksandr Halavatyi, Andrew J. Fisher, Rainer Pepperkok, Johanna Vappiani, Thomas Muley, Giovanna Bergamini, Christian Tischer, Natasja Staehr Gudmann, Jessica D. Eley, Daniel C. Sévin, Hauke Winter, Frank Stein, Muzamil Majid Khan, Nico Zinn, Carmel B. Nanthakumar, Daniel Poeckel
Fibrosis can affect any organ resulting in the loss of tissue architecture and function with often life-threatening consequences. Pathologically, fibrosis is characterised by expansion of connective tissue due to excessive deposition of extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437819a77789c432109344be2540b042
https://doi.org/10.1101/2019.12.13.875963
https://doi.org/10.1101/2019.12.13.875963