Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel Pluskal"'
Autor:
Michal Nemergut, Daniel Pluskal, Jana Horackova, Tereza Sustrova, Jan Tulis, Tomas Barta, Racha Baatallah, Glwadys Gagnot, Veronika Novakova, Marika Majerova, Karolina Sedlackova, Sérgio M. Marques, Martin Toul, Jiri Damborsky, Zbynek Prokop, David Bednar, Yves L. Janin, Martin Marek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques are combined, revealing that imidazopyrazinone luciferins bind to an
Externí odkaz:
https://doaj.org/article/02510bf81fd243d0bfed12a6fdc366d5
Autor:
Andrea Schenkmayerova, Gaspar P. Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T. Bornscheuer, Jiri Damborsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Directed evolution commonly relies on point mutations but InDels frequently occur in evolution. Here the authors report a protein-engineering framework based on InDel mutagenesis and fragment transplantation resulting in greater catalysis and longer
Externí odkaz:
https://doaj.org/article/3c18b7a5373d42f0b49ea5eb1b1dcbad
Autor:
Andrea Schenkmayerova, Martin Toul, Daniel Pluskal, Racha Baatallah, Glwadys Gagnot, Gaspar P. Pinto, Vinicius T. Santana, Marketa Stuchla, Petr Neugebauer, Pimchai Chaiyen, Jiri Damborsky, David Bednar, Yves L. Janin, Zbynek Prokop, Martin Marek
Publikováno v:
Nature Catalysis. 6:23-38
Autor:
Michal Nemergut, Daniel Pluskal, Jana Horackova, Tereza Sustrova, Jan Tulis, Tomas Barta, Racha Baatallah, Glwadys Gagnot, Veronika Novakova, Marika Majerova, Sérgio Marques, Martin Toul, Jiri Damborsky, David Bednar, Zbynek Prokop, Yves Janin, Martin Marek
NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques were combined, revealing that imidazopyrazinone luciferins bind to an intra-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcb06097d36634c51b15c0e9ce1e7ce
https://doi.org/10.1101/2022.12.05.519101
https://doi.org/10.1101/2022.12.05.519101
Autor:
Andrea Schenkmayerova, Martin Toul, Daniel Pluskal, Racha Baatallah, Glwadys Gagnot, Gaspar P. Pinto, Vinicius T. Santana, Marketa Stuchla, Petr Neugebauer, Pimchai Chaiyen, Jiri Damborsky, David Bednar, Yves L. Janin, Zbynek Prokop, Martin Marek
The widely used coelenterazine-powered Renilla luciferase was discovered over 40 years ago but the oxidative mechanism by which it generates blue photons remains unclear. Here we decipher Renilla-type bioluminescence through crystallographic, spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d06a2f7a8e1b60a2082bbb00cbf9554
https://doi.org/10.1101/2022.02.09.479090
https://doi.org/10.1101/2022.02.09.479090
Autor:
Daniel Pluskal, David Bednar, Doerr M, Jiri Damborsky, Joan Planas-Iglesias, Martin Toul, Michal Vasina, Florian Hollfelder, Gaspar Pinto, Andrea Schenkmayerová, Liskova, Zbyněk Prokop, Uwe T. Bornscheuer, Stéphane Emond, Martin Marek, Radka Chaloupková, Lenka Hernychová
Insertion-deletion mutations are sources of major functional innovations in naturally evolved proteins, but directed evolution methods rely primarily on substitutions. Here, we report a powerful strategy for engineering backbone dynamics based on InD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4019cb7fa5d4e7fc20cc03af368859
https://doi.org/10.26434/chemrxiv.12808295.v1
https://doi.org/10.26434/chemrxiv.12808295.v1
Autor:
Lenka Hernychová, Zbynek Prokop, Mark Dörr, David Bednar, Andrea Schenkmayerova, Jiri Damborsky, Radka Chaloupková, Stéphane Emond, Daniel Pluskal, Uwe T. Bornscheuer, Veronika Liskova, Michal Vasina, Joan Planas-Iglesias, Martin Toul, Florian Hollfelder, Gaspar Pinto, Martin Marek
Publikováno v:
Nature Communications
'Nature Communications ', vol: 12, pages: 3616-1-3616-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
'Nature Communications ', vol: 12, pages: 3616-1-3616-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral protein AncHLD-RLuc which catalyses b
Autor:
Lenka Hernychová, Radka Chaloupková, K. Markova, Zbyněk Prokop, Daniel Pluskal, Eva Sebestova, José Gaspar Rangel Pamplona Pizarro Pinto, Jiří Damborský, Martin Marek, Veronika Liskova, Jitka Waterman, Martin Toul
To obtain structural insights into the emergence of biological functions from catalytically promiscuous enzymes, we reconstructed an ancestor of catalytically distinct, but evolutionarily related, haloalkane dehalogenases (EC 3.8.1.5) and Renilla luc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b741679e28e87568faa76ed9bb7d9189
https://zenodo.org/record/3966753
https://zenodo.org/record/3966753